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A Higher Angiogenin Expression is Associated With a Nonnuclear Maspin Location in Laryngeal Carcinoma.

Lovato A, Lionello M, Staffieri A, Blandamura S, Tealdo G, Giacomelli L, Staffieri C, Marioni G - Clin Exp Otorhinolaryngol (2015)

Bottom Line: The mean ANG expression was significantly higher in cases with loco-regional recurrent disease (P=0.007); and patients with an ANG expression ≥5.0% had a significantly shorter DFS than those with an ANG expression <5.0% (P=0.007).On multivariate analysis, ANG expression ≥5.0% was a significant, independent, negative prognostic factor in terms of DFS (P=0.041).Our results support the hypothesis that a higher ANG expression is associated with a nonnuclear Maspin expression pattern in patients with LSCC.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy.

ABSTRACT

Objectives: In numerous malignancies, angiogenin (ANG) and Maspin are important proangiogenic and antiangiogenic regulators, respectively. The aim of this study was to identify potential relationships between the biological roles of these two proteins in laryngeal squamous cell carcinoma (LSCC).

Methods: Immunohistochemical staining for ANG and Maspin was performed on specimens from 76 consecutive LSCC patients treated with surgery alone, considering the subcellular pattern of Maspin expression. Univariate and multivariate statistical models were used for prognostic purposes.

Results: On univariate analysis, a different level of ANG expression was seen for patients stratified by subcellular Maspin expression pattern: the mean ANG expression was higher in cases with a nonnuclear MASPIN expression than in those with a nuclear pattern (P=0.002). Disease-free survival (DFS; in months) differed significantly when patients were stratified by N stage (P=0.01). Patients whose Maspin expression was nonnuclear (i.e., it was cytoplasmic or there was none) had a significantly higher recurrence rate (P<0.001), and shorter DFS (P=0.01) than those with a nuclear Maspin pattern. The mean ANG expression was significantly higher in cases with loco-regional recurrent disease (P=0.007); and patients with an ANG expression ≥5.0% had a significantly shorter DFS than those with an ANG expression <5.0% (P=0.007). On multivariate analysis, ANG expression ≥5.0% was a significant, independent, negative prognostic factor in terms of DFS (P=0.041).

Conclusion: Our results support the hypothesis that a higher ANG expression is associated with a nonnuclear Maspin expression pattern in patients with LSCC. Further studies are needed to clarify the relationship between the ANG and Maspin pathways, and their potential diagnostic and therapeutic role in LSCC.

No MeSH data available.


Related in: MedlinePlus

Square root transformed box plot showing the different angiogenin (ANG) expression in patients stratified by subcellular Maspin expression pattern: mean ANG expression was higher in patients with a nonnuclear Maspin expression pattern (nonnuclear) than in those with a nuclear pattern (nuclear).
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Figure 3: Square root transformed box plot showing the different angiogenin (ANG) expression in patients stratified by subcellular Maspin expression pattern: mean ANG expression was higher in patients with a nonnuclear Maspin expression pattern (nonnuclear) than in those with a nuclear pattern (nuclear).

Mentions: Student t-test corrected for unequal variances showed different levels of ANG expression in patients stratified by their subcellular Maspin expression pattern: the mean ANG expression was higher in patients with a nonnuclear pattern of Maspin expression than in those with a nuclear pattern (P=0.002) (Fig. 3).


A Higher Angiogenin Expression is Associated With a Nonnuclear Maspin Location in Laryngeal Carcinoma.

Lovato A, Lionello M, Staffieri A, Blandamura S, Tealdo G, Giacomelli L, Staffieri C, Marioni G - Clin Exp Otorhinolaryngol (2015)

Square root transformed box plot showing the different angiogenin (ANG) expression in patients stratified by subcellular Maspin expression pattern: mean ANG expression was higher in patients with a nonnuclear Maspin expression pattern (nonnuclear) than in those with a nuclear pattern (nuclear).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4553359&req=5

Figure 3: Square root transformed box plot showing the different angiogenin (ANG) expression in patients stratified by subcellular Maspin expression pattern: mean ANG expression was higher in patients with a nonnuclear Maspin expression pattern (nonnuclear) than in those with a nuclear pattern (nuclear).
Mentions: Student t-test corrected for unequal variances showed different levels of ANG expression in patients stratified by their subcellular Maspin expression pattern: the mean ANG expression was higher in patients with a nonnuclear pattern of Maspin expression than in those with a nuclear pattern (P=0.002) (Fig. 3).

Bottom Line: The mean ANG expression was significantly higher in cases with loco-regional recurrent disease (P=0.007); and patients with an ANG expression ≥5.0% had a significantly shorter DFS than those with an ANG expression <5.0% (P=0.007).On multivariate analysis, ANG expression ≥5.0% was a significant, independent, negative prognostic factor in terms of DFS (P=0.041).Our results support the hypothesis that a higher ANG expression is associated with a nonnuclear Maspin expression pattern in patients with LSCC.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy.

ABSTRACT

Objectives: In numerous malignancies, angiogenin (ANG) and Maspin are important proangiogenic and antiangiogenic regulators, respectively. The aim of this study was to identify potential relationships between the biological roles of these two proteins in laryngeal squamous cell carcinoma (LSCC).

Methods: Immunohistochemical staining for ANG and Maspin was performed on specimens from 76 consecutive LSCC patients treated with surgery alone, considering the subcellular pattern of Maspin expression. Univariate and multivariate statistical models were used for prognostic purposes.

Results: On univariate analysis, a different level of ANG expression was seen for patients stratified by subcellular Maspin expression pattern: the mean ANG expression was higher in cases with a nonnuclear MASPIN expression than in those with a nuclear pattern (P=0.002). Disease-free survival (DFS; in months) differed significantly when patients were stratified by N stage (P=0.01). Patients whose Maspin expression was nonnuclear (i.e., it was cytoplasmic or there was none) had a significantly higher recurrence rate (P<0.001), and shorter DFS (P=0.01) than those with a nuclear Maspin pattern. The mean ANG expression was significantly higher in cases with loco-regional recurrent disease (P=0.007); and patients with an ANG expression ≥5.0% had a significantly shorter DFS than those with an ANG expression <5.0% (P=0.007). On multivariate analysis, ANG expression ≥5.0% was a significant, independent, negative prognostic factor in terms of DFS (P=0.041).

Conclusion: Our results support the hypothesis that a higher ANG expression is associated with a nonnuclear Maspin expression pattern in patients with LSCC. Further studies are needed to clarify the relationship between the ANG and Maspin pathways, and their potential diagnostic and therapeutic role in LSCC.

No MeSH data available.


Related in: MedlinePlus