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Vitamin D and Alzheimer's Disease: Neurocognition to Therapeutics.

Banerjee A, Khemka VK, Ganguly A, Roy D, Ganguly U, Chakrabarti S - Int J Alzheimers Dis (2015)

Bottom Line: The sporadic form of AD accounts for nearly 90% of the patients developing this disease.This review encompasses the beneficial role of vitamin D in neurocognition and optimal brain health along with epidemiological evidence of the high prevalence of hypovitaminosis D among aged and AD population.Moreover, disrupted signaling, altered utilization of vitamin D, and polymorphisms of several related genes including vitamin D receptor (VDR) also predispose to AD or AD-like neurodegeneration.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, ICARE Institute of Medical Sciences and Research, Haldia 721645, India ; Department of Biochemistry, Institute of Post Graduate Medical Education and Research, Kolkata 700020, India.

ABSTRACT
Alzheimer's disease (AD), the major cause of dementia worldwide, is characterized by progressive loss of memory and cognition. The sporadic form of AD accounts for nearly 90% of the patients developing this disease. The last century has witnessed significant research to identify various mechanisms and risk factors contributing to the complex etiopathogenesis of AD by analyzing postmortem AD brains and experimenting with animal and cell culture based models. However, the treatment strategies, as of now, are only symptomatic. Accumulating evidences suggested a significant association between vitamin D deficiency, dementia, and AD. This review encompasses the beneficial role of vitamin D in neurocognition and optimal brain health along with epidemiological evidence of the high prevalence of hypovitaminosis D among aged and AD population. Moreover, disrupted signaling, altered utilization of vitamin D, and polymorphisms of several related genes including vitamin D receptor (VDR) also predispose to AD or AD-like neurodegeneration. This review explores the relationship between this gene-environmental influence and long term vitamin D deficiency as a risk factor for development of sporadic AD along with the role and rationale of therapeutic trials with vitamin D. It is, therefore, urgently warranted to further establish the role of this potentially neuroprotective vitamin in preventing and halting progressive neurodegeneration in AD patients.

No MeSH data available.


Related in: MedlinePlus

Mechanisms of 1,25 OH vitamin D mediated multitargeted neuroprotection in AD. VDR: vitamin D receptor, RXR: retinoid X receptor, MARRS: membrane associated rapid response receptors, and LVSCC: L voltage sensitive calcium channel.
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Related In: Results  -  Collection


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fig2: Mechanisms of 1,25 OH vitamin D mediated multitargeted neuroprotection in AD. VDR: vitamin D receptor, RXR: retinoid X receptor, MARRS: membrane associated rapid response receptors, and LVSCC: L voltage sensitive calcium channel.

Mentions: Multiple pathogenic mechanisms implicated in the pathogenesis of sporadic AD and multifaceted neuroprotective role of 1,25-dihydroxyvitamin D are summed up above (Figure 2). In addition to the above mentioned mechanisms, the protective role of vitamin D in the cardiovascular system is exerted through cardiac remodeling, endothelial response regulation to injury, and blood coagulation, ultimately improving the CNS vascular homeostasis. Thus, in this manner vitamin D indirectly protects the brain form cerebrovascular risk factors of AD [85].


Vitamin D and Alzheimer's Disease: Neurocognition to Therapeutics.

Banerjee A, Khemka VK, Ganguly A, Roy D, Ganguly U, Chakrabarti S - Int J Alzheimers Dis (2015)

Mechanisms of 1,25 OH vitamin D mediated multitargeted neuroprotection in AD. VDR: vitamin D receptor, RXR: retinoid X receptor, MARRS: membrane associated rapid response receptors, and LVSCC: L voltage sensitive calcium channel.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4553343&req=5

fig2: Mechanisms of 1,25 OH vitamin D mediated multitargeted neuroprotection in AD. VDR: vitamin D receptor, RXR: retinoid X receptor, MARRS: membrane associated rapid response receptors, and LVSCC: L voltage sensitive calcium channel.
Mentions: Multiple pathogenic mechanisms implicated in the pathogenesis of sporadic AD and multifaceted neuroprotective role of 1,25-dihydroxyvitamin D are summed up above (Figure 2). In addition to the above mentioned mechanisms, the protective role of vitamin D in the cardiovascular system is exerted through cardiac remodeling, endothelial response regulation to injury, and blood coagulation, ultimately improving the CNS vascular homeostasis. Thus, in this manner vitamin D indirectly protects the brain form cerebrovascular risk factors of AD [85].

Bottom Line: The sporadic form of AD accounts for nearly 90% of the patients developing this disease.This review encompasses the beneficial role of vitamin D in neurocognition and optimal brain health along with epidemiological evidence of the high prevalence of hypovitaminosis D among aged and AD population.Moreover, disrupted signaling, altered utilization of vitamin D, and polymorphisms of several related genes including vitamin D receptor (VDR) also predispose to AD or AD-like neurodegeneration.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, ICARE Institute of Medical Sciences and Research, Haldia 721645, India ; Department of Biochemistry, Institute of Post Graduate Medical Education and Research, Kolkata 700020, India.

ABSTRACT
Alzheimer's disease (AD), the major cause of dementia worldwide, is characterized by progressive loss of memory and cognition. The sporadic form of AD accounts for nearly 90% of the patients developing this disease. The last century has witnessed significant research to identify various mechanisms and risk factors contributing to the complex etiopathogenesis of AD by analyzing postmortem AD brains and experimenting with animal and cell culture based models. However, the treatment strategies, as of now, are only symptomatic. Accumulating evidences suggested a significant association between vitamin D deficiency, dementia, and AD. This review encompasses the beneficial role of vitamin D in neurocognition and optimal brain health along with epidemiological evidence of the high prevalence of hypovitaminosis D among aged and AD population. Moreover, disrupted signaling, altered utilization of vitamin D, and polymorphisms of several related genes including vitamin D receptor (VDR) also predispose to AD or AD-like neurodegeneration. This review explores the relationship between this gene-environmental influence and long term vitamin D deficiency as a risk factor for development of sporadic AD along with the role and rationale of therapeutic trials with vitamin D. It is, therefore, urgently warranted to further establish the role of this potentially neuroprotective vitamin in preventing and halting progressive neurodegeneration in AD patients.

No MeSH data available.


Related in: MedlinePlus