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Addenbrooke's Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson's Disease.

Berankova D, Janousova E, Mrackova M, Eliasova I, Kostalova M, Skutilova S, Rektorova I - Parkinsons Dis (2015)

Bottom Line: Results.Statistically significant differences between groups were demonstrated in global ACE-R scores and subscores, except in the language domain.ACE-R scores except for ACE-R language correlated with specific cognitive tests of interest.

View Article: PubMed Central - PubMed

Affiliation: Applied Neuroscience Research Group, CEITEC MU, Masaryk University, 625 00 Brno, Czech Republic ; Department of Neurology, University Hospital in Ostrava, 708 52 Ostrava, Czech Republic ; Department of Rehabilitation, Faculty of Medicine, University of Ostrava, 708 52 Ostrava, Czech Republic.

ABSTRACT
Objective. The main aim of this study was to verify the sensitivity and specificity of Addenbrooke's Cognitive Examination-Revised (ACE-R) in discriminating between Parkinson's disease (PD) with normal cognition (PD-NC) and PD with mild cognitive impairment (PD-MCI) and between PD-MCI and PD with dementia (PD-D). We also evaluated how ACE-R correlates with neuropsychological cognitive tests in PD. Methods. We examined three age-matched groups of PD patients diagnosed according to the Movement Disorder Society Task Force criteria: PD-NC, PD-MCI, and PD-D. ROC analysis was used to establish specific cut-off scores of ACE-R and its domains. Correlation analyses were performed between ACE-R and its subtests with relevant neuropsychological tests. Results. Statistically significant differences between groups were demonstrated in global ACE-R scores and subscores, except in the language domain. ACE-R cut-off score of 88.5 points discriminated best between PD-MCI and PD-NC (sensitivity 0.68, specificity 0.91); ACE-R of 82.5 points distinguished best between PD-MCI and PD-D (sensitivity 0.70, specificity 0.73). The verbal fluency domain of ACE-R demonstrated the best discrimination between PD-NC and PD-MCI (cut-off score 11.5; sensitivity 0.70, specificity 0.73) while the orientation/attention subscore was best between PD-MCI and PD-D (cut-off score 15.5; sensitivity 0.90, specificity 0.97). ACE-R scores except for ACE-R language correlated with specific cognitive tests of interest.

No MeSH data available.


Related in: MedlinePlus

ROC curves distinguishing between patient groups using ACE-R and its subtests. ACE-R OA: orientation and attention domain of ACE-R, ACE-R M: memory domain of ACE-R, ACE-R F: verbal fluency domain of ACE-R, ACE-R L: language domain of ACE-R, ACE-R VA: visuospatial abilities domain of ACE-R, AUC: area under the curve, PD-NC: Parkinson's disease with normal cognition, PD-MCI: Parkinson's disease with mild cognitive impairment, and PD-D: Parkinson's disease with dementia.
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Related In: Results  -  Collection


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fig1: ROC curves distinguishing between patient groups using ACE-R and its subtests. ACE-R OA: orientation and attention domain of ACE-R, ACE-R M: memory domain of ACE-R, ACE-R F: verbal fluency domain of ACE-R, ACE-R L: language domain of ACE-R, ACE-R VA: visuospatial abilities domain of ACE-R, AUC: area under the curve, PD-NC: Parkinson's disease with normal cognition, PD-MCI: Parkinson's disease with mild cognitive impairment, and PD-D: Parkinson's disease with dementia.

Mentions: Results of ROC analysis including AUC estimates (with 95% confidence intervals) are summarized in Table 2 and visualized via ROC curves in Figure 1. Cut-off scores for global scores of ACE-R and its domains are displayed in Table 2. The ACE-R global cut-off score to differentiate between PD-NC and PD-MCI is 88.5 points (with 0.68 sensitivity and 0.91 specificity) and 82.5 points (with 0.70 sensitivity and 0.73 specificity) to differentiate between PD-MCI and PD-D.


Addenbrooke's Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson's Disease.

Berankova D, Janousova E, Mrackova M, Eliasova I, Kostalova M, Skutilova S, Rektorova I - Parkinsons Dis (2015)

ROC curves distinguishing between patient groups using ACE-R and its subtests. ACE-R OA: orientation and attention domain of ACE-R, ACE-R M: memory domain of ACE-R, ACE-R F: verbal fluency domain of ACE-R, ACE-R L: language domain of ACE-R, ACE-R VA: visuospatial abilities domain of ACE-R, AUC: area under the curve, PD-NC: Parkinson's disease with normal cognition, PD-MCI: Parkinson's disease with mild cognitive impairment, and PD-D: Parkinson's disease with dementia.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4553334&req=5

fig1: ROC curves distinguishing between patient groups using ACE-R and its subtests. ACE-R OA: orientation and attention domain of ACE-R, ACE-R M: memory domain of ACE-R, ACE-R F: verbal fluency domain of ACE-R, ACE-R L: language domain of ACE-R, ACE-R VA: visuospatial abilities domain of ACE-R, AUC: area under the curve, PD-NC: Parkinson's disease with normal cognition, PD-MCI: Parkinson's disease with mild cognitive impairment, and PD-D: Parkinson's disease with dementia.
Mentions: Results of ROC analysis including AUC estimates (with 95% confidence intervals) are summarized in Table 2 and visualized via ROC curves in Figure 1. Cut-off scores for global scores of ACE-R and its domains are displayed in Table 2. The ACE-R global cut-off score to differentiate between PD-NC and PD-MCI is 88.5 points (with 0.68 sensitivity and 0.91 specificity) and 82.5 points (with 0.70 sensitivity and 0.73 specificity) to differentiate between PD-MCI and PD-D.

Bottom Line: Results.Statistically significant differences between groups were demonstrated in global ACE-R scores and subscores, except in the language domain.ACE-R scores except for ACE-R language correlated with specific cognitive tests of interest.

View Article: PubMed Central - PubMed

Affiliation: Applied Neuroscience Research Group, CEITEC MU, Masaryk University, 625 00 Brno, Czech Republic ; Department of Neurology, University Hospital in Ostrava, 708 52 Ostrava, Czech Republic ; Department of Rehabilitation, Faculty of Medicine, University of Ostrava, 708 52 Ostrava, Czech Republic.

ABSTRACT
Objective. The main aim of this study was to verify the sensitivity and specificity of Addenbrooke's Cognitive Examination-Revised (ACE-R) in discriminating between Parkinson's disease (PD) with normal cognition (PD-NC) and PD with mild cognitive impairment (PD-MCI) and between PD-MCI and PD with dementia (PD-D). We also evaluated how ACE-R correlates with neuropsychological cognitive tests in PD. Methods. We examined three age-matched groups of PD patients diagnosed according to the Movement Disorder Society Task Force criteria: PD-NC, PD-MCI, and PD-D. ROC analysis was used to establish specific cut-off scores of ACE-R and its domains. Correlation analyses were performed between ACE-R and its subtests with relevant neuropsychological tests. Results. Statistically significant differences between groups were demonstrated in global ACE-R scores and subscores, except in the language domain. ACE-R cut-off score of 88.5 points discriminated best between PD-MCI and PD-NC (sensitivity 0.68, specificity 0.91); ACE-R of 82.5 points distinguished best between PD-MCI and PD-D (sensitivity 0.70, specificity 0.73). The verbal fluency domain of ACE-R demonstrated the best discrimination between PD-NC and PD-MCI (cut-off score 11.5; sensitivity 0.70, specificity 0.73) while the orientation/attention subscore was best between PD-MCI and PD-D (cut-off score 15.5; sensitivity 0.90, specificity 0.97). ACE-R scores except for ACE-R language correlated with specific cognitive tests of interest.

No MeSH data available.


Related in: MedlinePlus