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Waist-to-Hip Ratio, but Not Body Mass Index, Is Associated with Testosterone and Estradiol Concentrations in Young Women.

Mondragón-Ceballos R, García Granados MD, Cerda-Molina AL, Chavira-Ramírez R, Hernández-López LE - Int J Endocrinol (2015)

Bottom Line: Only in the fertile phase of the menstrual cycle we found a significant interaction between testosterone and estradiol affecting WHR (b ± s.e. = -0.000003 ± 0.000001;  t 94 = -2.12, adjusted R (2) = -0.008,  P = 0.03).Women with the highest levels of both hormones had the lowest WHRs, while women with low estradiol and high testosterone showed the highest WHRs.BMI significantly increased as testosterone increased in female in their nonfertile days.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Etología, Instituto Nacional de Psiquiatría, "Ramón de la Fuente Muñiz", Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 México, DF, Mexico.

ABSTRACT
We studied if testosterone and estradiol concentrations are associated with specific female waist-to-hip ratios (WHRs) and body mass indices (BMIs). Participants were 187 young women from which waist, hips, weight, and height were measured. In addition, participants informed on which day of their menstrual cycle they were and provided a 6 mL saliva sample. Ninety-one of them were in the follicular phase and 96 in the luteal phase. Only in the fertile phase of the menstrual cycle we found a significant interaction between testosterone and estradiol affecting WHR (b ± s.e. = -0.000003 ± 0.000001;  t 94 = -2.12, adjusted R (2) = -0.008,  P = 0.03). Women with the highest levels of both hormones had the lowest WHRs, while women with low estradiol and high testosterone showed the highest WHRs. BMI significantly increased as testosterone increased in female in their nonfertile days.

No MeSH data available.


Scatterplot showing the relationship between body mass index and waist-to-hip ratio of female participants in our study. Both variables were significantly correlated (P < 0.0001).
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fig1: Scatterplot showing the relationship between body mass index and waist-to-hip ratio of female participants in our study. Both variables were significantly correlated (P < 0.0001).

Mentions: Appreciate in Figure 1 that, in the total sample, WHR and BMI had a significant positive correlation (b ± s.e. = 0.01 ± 0.001; t185 = 7.05, R2 = 0.21, P < 0.0001). This positive association did not change with phase (fertile: b ± s.e. = 0.01 ± 0.001; t89 = 5.8, R2 = 0.27, P < 0.0001: nonfertile: b ± s.e. = 0.005 ± 0.001; t94 = 4.2, R2 = 0.16, P < 0.0001). However, the slope of the fertile days was significantly steeper than the one of the nonfertile days (t185 = 2.12, P = 0.035).


Waist-to-Hip Ratio, but Not Body Mass Index, Is Associated with Testosterone and Estradiol Concentrations in Young Women.

Mondragón-Ceballos R, García Granados MD, Cerda-Molina AL, Chavira-Ramírez R, Hernández-López LE - Int J Endocrinol (2015)

Scatterplot showing the relationship between body mass index and waist-to-hip ratio of female participants in our study. Both variables were significantly correlated (P < 0.0001).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4553330&req=5

fig1: Scatterplot showing the relationship between body mass index and waist-to-hip ratio of female participants in our study. Both variables were significantly correlated (P < 0.0001).
Mentions: Appreciate in Figure 1 that, in the total sample, WHR and BMI had a significant positive correlation (b ± s.e. = 0.01 ± 0.001; t185 = 7.05, R2 = 0.21, P < 0.0001). This positive association did not change with phase (fertile: b ± s.e. = 0.01 ± 0.001; t89 = 5.8, R2 = 0.27, P < 0.0001: nonfertile: b ± s.e. = 0.005 ± 0.001; t94 = 4.2, R2 = 0.16, P < 0.0001). However, the slope of the fertile days was significantly steeper than the one of the nonfertile days (t185 = 2.12, P = 0.035).

Bottom Line: Only in the fertile phase of the menstrual cycle we found a significant interaction between testosterone and estradiol affecting WHR (b ± s.e. = -0.000003 ± 0.000001;  t 94 = -2.12, adjusted R (2) = -0.008,  P = 0.03).Women with the highest levels of both hormones had the lowest WHRs, while women with low estradiol and high testosterone showed the highest WHRs.BMI significantly increased as testosterone increased in female in their nonfertile days.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Etología, Instituto Nacional de Psiquiatría, "Ramón de la Fuente Muñiz", Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 México, DF, Mexico.

ABSTRACT
We studied if testosterone and estradiol concentrations are associated with specific female waist-to-hip ratios (WHRs) and body mass indices (BMIs). Participants were 187 young women from which waist, hips, weight, and height were measured. In addition, participants informed on which day of their menstrual cycle they were and provided a 6 mL saliva sample. Ninety-one of them were in the follicular phase and 96 in the luteal phase. Only in the fertile phase of the menstrual cycle we found a significant interaction between testosterone and estradiol affecting WHR (b ± s.e. = -0.000003 ± 0.000001;  t 94 = -2.12, adjusted R (2) = -0.008,  P = 0.03). Women with the highest levels of both hormones had the lowest WHRs, while women with low estradiol and high testosterone showed the highest WHRs. BMI significantly increased as testosterone increased in female in their nonfertile days.

No MeSH data available.