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Studies on the Antifatigue Activities of Cordyceps militaris Fruit Body Extract in Mouse Model.

Song J, Wang Y, Teng M, Cai G, Xu H, Guo H, Liu Y, Wang D, Teng L - Evid Based Complement Alternat Med (2015)

Bottom Line: Cordyceps militaris has been used extensively as a crude drug and a folk tonic food in East Asia due to its various pharmacological activities.Moreover, CM-enhanced the phosphorylation of AMPK contributes to its antioxidant effect.Our data provides experimental evidence in supporting clinical use of CM as an effective agent against fatigue.

View Article: PubMed Central - PubMed

Affiliation: College of Life Sciences, Jilin University, Changchun 130012, China.

ABSTRACT
Cordyceps militaris has been used extensively as a crude drug and a folk tonic food in East Asia due to its various pharmacological activities. Our study aims to investigate the effect of Cordyceps militaris fruit body extract (CM) on antifatigue in mouse model. Two week CM administration significantly delayed fatigue phenomenon which is confirmed via rotating rod test, forced swimming test and forced running test. Compared to nontreated mouse, CM administration increased ATP levels and antioxidative enzymes activity and reduced the levels of lactic acid, lactic dehydrogenase, malondialdehyde, and reactive oxygen species. Further data suggests that CM-induced fatigue recovery is mainly through activating 5'-AMP-activated protein kinase (AMPK) and protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathways and regulating serum hormone level. Moreover, CM-enhanced the phosphorylation of AMPK contributes to its antioxidant effect. Our data provides experimental evidence in supporting clinical use of CM as an effective agent against fatigue.

No MeSH data available.


Related in: MedlinePlus

After 14-day Cordyceps militaris fruit body extract (0.5 g/kg, 1.0 g/kg, and 2.0 g/kg) and Rhodiola rosea (0.5 g/kg) treatment, the effects on ATP metabolism were analyzed in liver ((a), (b)) and muscle ((c), (d)) in both male and female mouse before and after 20 min swimming. Data are expressed as mean ± S.D. (n = 6) and analyzed using one-way ANOVA followed by Dunn's test. ∗P < 0.05 and ∗∗P < 0.01 versus nontreated mouse (Control).
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fig4: After 14-day Cordyceps militaris fruit body extract (0.5 g/kg, 1.0 g/kg, and 2.0 g/kg) and Rhodiola rosea (0.5 g/kg) treatment, the effects on ATP metabolism were analyzed in liver ((a), (b)) and muscle ((c), (d)) in both male and female mouse before and after 20 min swimming. Data are expressed as mean ± S.D. (n = 6) and analyzed using one-way ANOVA followed by Dunn's test. ∗P < 0.05 and ∗∗P < 0.01 versus nontreated mouse (Control).

Mentions: ATP is the most direct and rapid energy source to exercise. The higher level of ATP protects the muscle against membrane damage, and the increase in LDH release is associated with a decrease in the content of ATP [23]. After swimming, 2.0 g/kg CM treatment enhanced approximate 54.6% and 151.2% ATP concentration in liver and muscle compared with control group in female mouse (P < 0.05; Figures 4(a) and 4(b)) and 1.0 g/kg CM treatment enhanced 90.8% and 65.2% ATP concentration in liver and muscle compared with nontreated male mouse (P < 0.05; Figures 4(c) and 4(d)).


Studies on the Antifatigue Activities of Cordyceps militaris Fruit Body Extract in Mouse Model.

Song J, Wang Y, Teng M, Cai G, Xu H, Guo H, Liu Y, Wang D, Teng L - Evid Based Complement Alternat Med (2015)

After 14-day Cordyceps militaris fruit body extract (0.5 g/kg, 1.0 g/kg, and 2.0 g/kg) and Rhodiola rosea (0.5 g/kg) treatment, the effects on ATP metabolism were analyzed in liver ((a), (b)) and muscle ((c), (d)) in both male and female mouse before and after 20 min swimming. Data are expressed as mean ± S.D. (n = 6) and analyzed using one-way ANOVA followed by Dunn's test. ∗P < 0.05 and ∗∗P < 0.01 versus nontreated mouse (Control).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4553310&req=5

fig4: After 14-day Cordyceps militaris fruit body extract (0.5 g/kg, 1.0 g/kg, and 2.0 g/kg) and Rhodiola rosea (0.5 g/kg) treatment, the effects on ATP metabolism were analyzed in liver ((a), (b)) and muscle ((c), (d)) in both male and female mouse before and after 20 min swimming. Data are expressed as mean ± S.D. (n = 6) and analyzed using one-way ANOVA followed by Dunn's test. ∗P < 0.05 and ∗∗P < 0.01 versus nontreated mouse (Control).
Mentions: ATP is the most direct and rapid energy source to exercise. The higher level of ATP protects the muscle against membrane damage, and the increase in LDH release is associated with a decrease in the content of ATP [23]. After swimming, 2.0 g/kg CM treatment enhanced approximate 54.6% and 151.2% ATP concentration in liver and muscle compared with control group in female mouse (P < 0.05; Figures 4(a) and 4(b)) and 1.0 g/kg CM treatment enhanced 90.8% and 65.2% ATP concentration in liver and muscle compared with nontreated male mouse (P < 0.05; Figures 4(c) and 4(d)).

Bottom Line: Cordyceps militaris has been used extensively as a crude drug and a folk tonic food in East Asia due to its various pharmacological activities.Moreover, CM-enhanced the phosphorylation of AMPK contributes to its antioxidant effect.Our data provides experimental evidence in supporting clinical use of CM as an effective agent against fatigue.

View Article: PubMed Central - PubMed

Affiliation: College of Life Sciences, Jilin University, Changchun 130012, China.

ABSTRACT
Cordyceps militaris has been used extensively as a crude drug and a folk tonic food in East Asia due to its various pharmacological activities. Our study aims to investigate the effect of Cordyceps militaris fruit body extract (CM) on antifatigue in mouse model. Two week CM administration significantly delayed fatigue phenomenon which is confirmed via rotating rod test, forced swimming test and forced running test. Compared to nontreated mouse, CM administration increased ATP levels and antioxidative enzymes activity and reduced the levels of lactic acid, lactic dehydrogenase, malondialdehyde, and reactive oxygen species. Further data suggests that CM-induced fatigue recovery is mainly through activating 5'-AMP-activated protein kinase (AMPK) and protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathways and regulating serum hormone level. Moreover, CM-enhanced the phosphorylation of AMPK contributes to its antioxidant effect. Our data provides experimental evidence in supporting clinical use of CM as an effective agent against fatigue.

No MeSH data available.


Related in: MedlinePlus