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Studies on the Antifatigue Activities of Cordyceps militaris Fruit Body Extract in Mouse Model.

Song J, Wang Y, Teng M, Cai G, Xu H, Guo H, Liu Y, Wang D, Teng L - Evid Based Complement Alternat Med (2015)

Bottom Line: Cordyceps militaris has been used extensively as a crude drug and a folk tonic food in East Asia due to its various pharmacological activities.Moreover, CM-enhanced the phosphorylation of AMPK contributes to its antioxidant effect.Our data provides experimental evidence in supporting clinical use of CM as an effective agent against fatigue.

View Article: PubMed Central - PubMed

Affiliation: College of Life Sciences, Jilin University, Changchun 130012, China.

ABSTRACT
Cordyceps militaris has been used extensively as a crude drug and a folk tonic food in East Asia due to its various pharmacological activities. Our study aims to investigate the effect of Cordyceps militaris fruit body extract (CM) on antifatigue in mouse model. Two week CM administration significantly delayed fatigue phenomenon which is confirmed via rotating rod test, forced swimming test and forced running test. Compared to nontreated mouse, CM administration increased ATP levels and antioxidative enzymes activity and reduced the levels of lactic acid, lactic dehydrogenase, malondialdehyde, and reactive oxygen species. Further data suggests that CM-induced fatigue recovery is mainly through activating 5'-AMP-activated protein kinase (AMPK) and protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathways and regulating serum hormone level. Moreover, CM-enhanced the phosphorylation of AMPK contributes to its antioxidant effect. Our data provides experimental evidence in supporting clinical use of CM as an effective agent against fatigue.

No MeSH data available.


Related in: MedlinePlus

The antifatigue effects of Cordyceps militaris fruit body extract (0.5 g/kg, 1.0 g/kg, and 2.0 g/kg) and Rhodiola rosea (0.5 g/kg) were analyzed through rotating rod test (a), forced running test (b), and forced swimming test (c). Data are expressed as mean ± S.D. (n = 10) and analyzed using one-way ANOVA followed by Dunn's test. ∗P < 0.05 and ∗∗P < 0.01 versus nontreated mouse (Control).
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Related In: Results  -  Collection


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fig1: The antifatigue effects of Cordyceps militaris fruit body extract (0.5 g/kg, 1.0 g/kg, and 2.0 g/kg) and Rhodiola rosea (0.5 g/kg) were analyzed through rotating rod test (a), forced running test (b), and forced swimming test (c). Data are expressed as mean ± S.D. (n = 10) and analyzed using one-way ANOVA followed by Dunn's test. ∗P < 0.05 and ∗∗P < 0.01 versus nontreated mouse (Control).

Mentions: Rotating rod, forced swimming, and forced running test were performed to detect the antifatigue capacity of CM. 0.5 mg/kg Rhodiola rosea which significantly enhanced the residence time in all three tests. Similar to Rhodiola rosea, compared with nontreated mice, 2.0 g/kg CM treatment improved nearly 100.2% and 115.8% residence time in female and male mice in rotating rod test (P < 0.05; Figure 1(a)). In forced running test, the running times were strongly enhanced after 2-week CM administration (P < 0.05; Figure 1(b)). In forced swimming test, CM treatment strongly enhanced swimming time with maximum record of 3.0 min and 3.4 min in female and male mouse compared with nontreated group (P < 0.01; Figure 1(c)).


Studies on the Antifatigue Activities of Cordyceps militaris Fruit Body Extract in Mouse Model.

Song J, Wang Y, Teng M, Cai G, Xu H, Guo H, Liu Y, Wang D, Teng L - Evid Based Complement Alternat Med (2015)

The antifatigue effects of Cordyceps militaris fruit body extract (0.5 g/kg, 1.0 g/kg, and 2.0 g/kg) and Rhodiola rosea (0.5 g/kg) were analyzed through rotating rod test (a), forced running test (b), and forced swimming test (c). Data are expressed as mean ± S.D. (n = 10) and analyzed using one-way ANOVA followed by Dunn's test. ∗P < 0.05 and ∗∗P < 0.01 versus nontreated mouse (Control).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4553310&req=5

fig1: The antifatigue effects of Cordyceps militaris fruit body extract (0.5 g/kg, 1.0 g/kg, and 2.0 g/kg) and Rhodiola rosea (0.5 g/kg) were analyzed through rotating rod test (a), forced running test (b), and forced swimming test (c). Data are expressed as mean ± S.D. (n = 10) and analyzed using one-way ANOVA followed by Dunn's test. ∗P < 0.05 and ∗∗P < 0.01 versus nontreated mouse (Control).
Mentions: Rotating rod, forced swimming, and forced running test were performed to detect the antifatigue capacity of CM. 0.5 mg/kg Rhodiola rosea which significantly enhanced the residence time in all three tests. Similar to Rhodiola rosea, compared with nontreated mice, 2.0 g/kg CM treatment improved nearly 100.2% and 115.8% residence time in female and male mice in rotating rod test (P < 0.05; Figure 1(a)). In forced running test, the running times were strongly enhanced after 2-week CM administration (P < 0.05; Figure 1(b)). In forced swimming test, CM treatment strongly enhanced swimming time with maximum record of 3.0 min and 3.4 min in female and male mouse compared with nontreated group (P < 0.01; Figure 1(c)).

Bottom Line: Cordyceps militaris has been used extensively as a crude drug and a folk tonic food in East Asia due to its various pharmacological activities.Moreover, CM-enhanced the phosphorylation of AMPK contributes to its antioxidant effect.Our data provides experimental evidence in supporting clinical use of CM as an effective agent against fatigue.

View Article: PubMed Central - PubMed

Affiliation: College of Life Sciences, Jilin University, Changchun 130012, China.

ABSTRACT
Cordyceps militaris has been used extensively as a crude drug and a folk tonic food in East Asia due to its various pharmacological activities. Our study aims to investigate the effect of Cordyceps militaris fruit body extract (CM) on antifatigue in mouse model. Two week CM administration significantly delayed fatigue phenomenon which is confirmed via rotating rod test, forced swimming test and forced running test. Compared to nontreated mouse, CM administration increased ATP levels and antioxidative enzymes activity and reduced the levels of lactic acid, lactic dehydrogenase, malondialdehyde, and reactive oxygen species. Further data suggests that CM-induced fatigue recovery is mainly through activating 5'-AMP-activated protein kinase (AMPK) and protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathways and regulating serum hormone level. Moreover, CM-enhanced the phosphorylation of AMPK contributes to its antioxidant effect. Our data provides experimental evidence in supporting clinical use of CM as an effective agent against fatigue.

No MeSH data available.


Related in: MedlinePlus