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Prognostic Role of MicroRNA-126 for Survival in Malignant Tumors: A Systematic Review and Meta-Analysis.

Bu J, Li H, Li XY, Liu LH, Sun W, Xiao T - Dis. Markers (2015)

Bottom Line: Eligible studies were identified by searching in PubMed, Embase, the Cochrane Library, CNKI, and Wan Fang databases up to March 2015.Thirty studies including a total of 4497 participants were enrolled in this meta-analysis.The pooled results showed that high level of miR-126 was a predictor for favorable survival of carcinomas, with pooled HR of 0.77 (95% CI 0.64-0.93) for OS, 0.64 (95%CI 0.48-0.85) for DFS, and 0.70 (95% CI 0.50-0.98) for PFS/RFS/DSS.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha 410010, China.

ABSTRACT

Background: Increasing studies found that miR-126 expression may be associated with the prognosis of cancers. Here, we performed a meta-analysis to assess the prognostic role of miR-126 in different cancers.

Methods: Eligible studies were identified by searching in PubMed, Embase, the Cochrane Library, CNKI, and Wan Fang databases up to March 2015. Pooled hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) were calculated to investigate the correlation between miR-126 and survival of cancers.

Results: Thirty studies including a total of 4497 participants were enrolled in this meta-analysis. The pooled results showed that high level of miR-126 was a predictor for favorable survival of carcinomas, with pooled HR of 0.77 (95% CI 0.64-0.93) for OS, 0.64 (95%CI 0.48-0.85) for DFS, and 0.70 (95% CI 0.50-0.98) for PFS/RFS/DSS. However, high level of circulating miR-126 predicted a significantly worse OS in patients with cancer (HR = 1.65, 95% CI 1.09-2.51).

Conclusions: Our results indicated that miR-126 could act as a significant biomarker in the prognosis of various cancers.

No MeSH data available.


Related in: MedlinePlus

Sensitivity analyses of studies concerning miR-126 and overall survival (OS).
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Related In: Results  -  Collection


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fig4: Sensitivity analyses of studies concerning miR-126 and overall survival (OS).

Mentions: Furthermore, we performed sensitivity analysis to investigate the influence of each individual study on the overall meta-analysis estimate, which computes the pooled HRs by omitting one study in each turn. And there was no obvious influence of individual study on the pooled HRs (Figure 4 and Figures S2 and S4).


Prognostic Role of MicroRNA-126 for Survival in Malignant Tumors: A Systematic Review and Meta-Analysis.

Bu J, Li H, Li XY, Liu LH, Sun W, Xiao T - Dis. Markers (2015)

Sensitivity analyses of studies concerning miR-126 and overall survival (OS).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4553299&req=5

fig4: Sensitivity analyses of studies concerning miR-126 and overall survival (OS).
Mentions: Furthermore, we performed sensitivity analysis to investigate the influence of each individual study on the overall meta-analysis estimate, which computes the pooled HRs by omitting one study in each turn. And there was no obvious influence of individual study on the pooled HRs (Figure 4 and Figures S2 and S4).

Bottom Line: Eligible studies were identified by searching in PubMed, Embase, the Cochrane Library, CNKI, and Wan Fang databases up to March 2015.Thirty studies including a total of 4497 participants were enrolled in this meta-analysis.The pooled results showed that high level of miR-126 was a predictor for favorable survival of carcinomas, with pooled HR of 0.77 (95% CI 0.64-0.93) for OS, 0.64 (95%CI 0.48-0.85) for DFS, and 0.70 (95% CI 0.50-0.98) for PFS/RFS/DSS.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha 410010, China.

ABSTRACT

Background: Increasing studies found that miR-126 expression may be associated with the prognosis of cancers. Here, we performed a meta-analysis to assess the prognostic role of miR-126 in different cancers.

Methods: Eligible studies were identified by searching in PubMed, Embase, the Cochrane Library, CNKI, and Wan Fang databases up to March 2015. Pooled hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) were calculated to investigate the correlation between miR-126 and survival of cancers.

Results: Thirty studies including a total of 4497 participants were enrolled in this meta-analysis. The pooled results showed that high level of miR-126 was a predictor for favorable survival of carcinomas, with pooled HR of 0.77 (95% CI 0.64-0.93) for OS, 0.64 (95%CI 0.48-0.85) for DFS, and 0.70 (95% CI 0.50-0.98) for PFS/RFS/DSS. However, high level of circulating miR-126 predicted a significantly worse OS in patients with cancer (HR = 1.65, 95% CI 1.09-2.51).

Conclusions: Our results indicated that miR-126 could act as a significant biomarker in the prognosis of various cancers.

No MeSH data available.


Related in: MedlinePlus