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Prognostic Role of MicroRNA-126 for Survival in Malignant Tumors: A Systematic Review and Meta-Analysis.

Bu J, Li H, Li XY, Liu LH, Sun W, Xiao T - Dis. Markers (2015)

Bottom Line: Eligible studies were identified by searching in PubMed, Embase, the Cochrane Library, CNKI, and Wan Fang databases up to March 2015.Thirty studies including a total of 4497 participants were enrolled in this meta-analysis.The pooled results showed that high level of miR-126 was a predictor for favorable survival of carcinomas, with pooled HR of 0.77 (95% CI 0.64-0.93) for OS, 0.64 (95%CI 0.48-0.85) for DFS, and 0.70 (95% CI 0.50-0.98) for PFS/RFS/DSS.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha 410010, China.

ABSTRACT

Background: Increasing studies found that miR-126 expression may be associated with the prognosis of cancers. Here, we performed a meta-analysis to assess the prognostic role of miR-126 in different cancers.

Methods: Eligible studies were identified by searching in PubMed, Embase, the Cochrane Library, CNKI, and Wan Fang databases up to March 2015. Pooled hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) were calculated to investigate the correlation between miR-126 and survival of cancers.

Results: Thirty studies including a total of 4497 participants were enrolled in this meta-analysis. The pooled results showed that high level of miR-126 was a predictor for favorable survival of carcinomas, with pooled HR of 0.77 (95% CI 0.64-0.93) for OS, 0.64 (95%CI 0.48-0.85) for DFS, and 0.70 (95% CI 0.50-0.98) for PFS/RFS/DSS. However, high level of circulating miR-126 predicted a significantly worse OS in patients with cancer (HR = 1.65, 95% CI 1.09-2.51).

Conclusions: Our results indicated that miR-126 could act as a significant biomarker in the prognosis of various cancers.

No MeSH data available.


Related in: MedlinePlus

Begg's funnel plots of publication bias test for overall survival (OS).
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Related In: Results  -  Collection


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fig3: Begg's funnel plots of publication bias test for overall survival (OS).

Mentions: Begg's funnel plot and Egger's test were used to assess the potential publication bias of the included studies. The funnel plots of the OS, DFS, and PFS/RFS/DSS analysis based on tissue and blood miR-126 did not reveal any evidence of obvious asymmetry. Moreover, the P values of Egger's and Begg's tests were all greater than 0.05 in the 30 analysis groups (Table 2, Figure 3, and Figures S1 and S3). Hence, there was no obvious risk of publication bias in our meta-analysis.


Prognostic Role of MicroRNA-126 for Survival in Malignant Tumors: A Systematic Review and Meta-Analysis.

Bu J, Li H, Li XY, Liu LH, Sun W, Xiao T - Dis. Markers (2015)

Begg's funnel plots of publication bias test for overall survival (OS).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4553299&req=5

fig3: Begg's funnel plots of publication bias test for overall survival (OS).
Mentions: Begg's funnel plot and Egger's test were used to assess the potential publication bias of the included studies. The funnel plots of the OS, DFS, and PFS/RFS/DSS analysis based on tissue and blood miR-126 did not reveal any evidence of obvious asymmetry. Moreover, the P values of Egger's and Begg's tests were all greater than 0.05 in the 30 analysis groups (Table 2, Figure 3, and Figures S1 and S3). Hence, there was no obvious risk of publication bias in our meta-analysis.

Bottom Line: Eligible studies were identified by searching in PubMed, Embase, the Cochrane Library, CNKI, and Wan Fang databases up to March 2015.Thirty studies including a total of 4497 participants were enrolled in this meta-analysis.The pooled results showed that high level of miR-126 was a predictor for favorable survival of carcinomas, with pooled HR of 0.77 (95% CI 0.64-0.93) for OS, 0.64 (95%CI 0.48-0.85) for DFS, and 0.70 (95% CI 0.50-0.98) for PFS/RFS/DSS.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha 410010, China.

ABSTRACT

Background: Increasing studies found that miR-126 expression may be associated with the prognosis of cancers. Here, we performed a meta-analysis to assess the prognostic role of miR-126 in different cancers.

Methods: Eligible studies were identified by searching in PubMed, Embase, the Cochrane Library, CNKI, and Wan Fang databases up to March 2015. Pooled hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) were calculated to investigate the correlation between miR-126 and survival of cancers.

Results: Thirty studies including a total of 4497 participants were enrolled in this meta-analysis. The pooled results showed that high level of miR-126 was a predictor for favorable survival of carcinomas, with pooled HR of 0.77 (95% CI 0.64-0.93) for OS, 0.64 (95%CI 0.48-0.85) for DFS, and 0.70 (95% CI 0.50-0.98) for PFS/RFS/DSS. However, high level of circulating miR-126 predicted a significantly worse OS in patients with cancer (HR = 1.65, 95% CI 1.09-2.51).

Conclusions: Our results indicated that miR-126 could act as a significant biomarker in the prognosis of various cancers.

No MeSH data available.


Related in: MedlinePlus