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The NIH Extracellular RNA Communication Consortium.

Ainsztein AM, Brooks PJ, Dugan VG, Ganguly A, Guo M, Howcroft TK, Kelley CA, Kuo LS, Labosky PA, Lenzi R, McKie GA, Mohla S, Procaccini D, Reilly M, Satterlee JS, Srinivas PR, Church ES, Sutherland M, Tagle DA, Tucker JM, Venkatachalam S - J Extracell Vesicles (2015)

Bottom Line: The Extracellular RNA (exRNA) Communication Consortium, funded as an initiative of the NIH Common Fund, represents a consortium of investigators assembled to address the critical issues in the exRNA research arena.The overarching goal is to generate a multi-component community resource for sharing fundamental scientific discoveries, protocols, and innovative tools and technologies.The key initiatives include (a) generating a reference catalogue of exRNAs present in body fluids of normal healthy individuals that would facilitate disease diagnosis and therapies, (b) defining the fundamental principles of exRNA biogenesis, distribution, uptake, and function, as well as development of molecular tools, technologies, and imaging modalities to enable these studies,

View Article: PubMed Central - PubMed

Affiliation: Division of Cell Biology and Biophysics, National Institute of General Medical Sciences (NIGMS), Bethesda, MD, USA.

No MeSH data available.


Structure of the Extracellular RNA Communication Consortium.
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Figure 0001: Structure of the Extracellular RNA Communication Consortium.

Mentions: As depicted in Fig. 1, the ERCC structure enables not only governance and oversight but also cross-Consortium working groups to generate best practices, standard operating procedures, and cross-validation. The 5 research initiatives of the ERCC (Fig. 1) are a) Biogenesis, b) Reference Profiles, c) Biomarker Development, d) Therapy Development and e) the Data Management and Resource Repository. A brief introduction to these collaborative scientific components is described below.


The NIH Extracellular RNA Communication Consortium.

Ainsztein AM, Brooks PJ, Dugan VG, Ganguly A, Guo M, Howcroft TK, Kelley CA, Kuo LS, Labosky PA, Lenzi R, McKie GA, Mohla S, Procaccini D, Reilly M, Satterlee JS, Srinivas PR, Church ES, Sutherland M, Tagle DA, Tucker JM, Venkatachalam S - J Extracell Vesicles (2015)

Structure of the Extracellular RNA Communication Consortium.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4553264&req=5

Figure 0001: Structure of the Extracellular RNA Communication Consortium.
Mentions: As depicted in Fig. 1, the ERCC structure enables not only governance and oversight but also cross-Consortium working groups to generate best practices, standard operating procedures, and cross-validation. The 5 research initiatives of the ERCC (Fig. 1) are a) Biogenesis, b) Reference Profiles, c) Biomarker Development, d) Therapy Development and e) the Data Management and Resource Repository. A brief introduction to these collaborative scientific components is described below.

Bottom Line: The Extracellular RNA (exRNA) Communication Consortium, funded as an initiative of the NIH Common Fund, represents a consortium of investigators assembled to address the critical issues in the exRNA research arena.The overarching goal is to generate a multi-component community resource for sharing fundamental scientific discoveries, protocols, and innovative tools and technologies.The key initiatives include (a) generating a reference catalogue of exRNAs present in body fluids of normal healthy individuals that would facilitate disease diagnosis and therapies, (b) defining the fundamental principles of exRNA biogenesis, distribution, uptake, and function, as well as development of molecular tools, technologies, and imaging modalities to enable these studies,

View Article: PubMed Central - PubMed

Affiliation: Division of Cell Biology and Biophysics, National Institute of General Medical Sciences (NIGMS), Bethesda, MD, USA.

No MeSH data available.