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Production of porous Calcium Phosphate (CaP) ceramics with aligned pores using ceramic/camphene-based co-extrusion.

Choi WY, Kim HE, Moon YW, Shin KH, Koh YH - Biomater Res (2015)

Bottom Line: Porous CaP ceramic scaffolds with aligned pores were successfully produced using ceramic/camphene-based co-extrusion.The porous CaP scaffolds showed excellent in vitro biocompatibility, suggesting their potential as the bone scaffold.Aligned porous CaP ceramic scaffolds with considerably enhanced mechanical properties and tailorable porosity would find very useful applications as the bone scaffold.

View Article: PubMed Central - PubMed

Affiliation: Department of Materials Science and Engineering, Seoul National University, Seoul, 151-742 Korea.

ABSTRACT

Background: Calcium phosphate (CaP) ceramics are one of the most valuable biomaterials for uses as the bone scaffold owing to their outstanding biocompatability, bioactivity, and biodegradation nature. In particular, these materials with an open porous structure can stimulate bone ingrowth into their 3-dimensionally interconnected pores. However, the creation of pores in bulk materials would inevitably cause a severe reduction in mechanical properties. Thus, it is a challenge to explore new ways of improving the mechanical properties of porous CaP scaffolds without scarifying their high porosity.

Results: Porous CaP ceramic scaffolds with aligned pores were successfully produced using ceramic/camphene-based co-extrusion. This aligned porous structure allowed for the achievement of high compressive strength when tested parallel to the direction of aligned pores. In addition, the overall porosity and mechanical properties of the aligned porous CaP ceramic scaffolds could be tailored simply by adjusting the initial CaP content in the CaP/camphene slurry. The porous CaP scaffolds showed excellent in vitro biocompatibility, suggesting their potential as the bone scaffold.

Conclusions: Aligned porous CaP ceramic scaffolds with considerably enhanced mechanical properties and tailorable porosity would find very useful applications as the bone scaffold.

No MeSH data available.


Compressive strengths of aligned porous CaP scaffolds produced without and with heat-treatment at 33 °C for 3 h (CaP contents: 15 vol%, 20 vol%, and 25 vol%). The compressive strengths between the samples are significantly different (p < 0.05)
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Fig6: Compressive strengths of aligned porous CaP scaffolds produced without and with heat-treatment at 33 °C for 3 h (CaP contents: 15 vol%, 20 vol%, and 25 vol%). The compressive strengths between the samples are significantly different (p < 0.05)

Mentions: Compressive strength tests were conducted for the aligned porous CaP scaffolds produced with various CaP contents (15 vol%, 20 vol%, and 25 vol%), in order to evaluate their mechanical function as a bone scaffold. The compressive strength increased from 3.3 ± 0.42 MPa to 6.3 ± 0.57 MPa with increasing initial CaP content from 15 vol% 25 vol%, as shown in Fig. 6 (a). This improvement was mainly attributed to a decrease in the overall porosity of the aligned porous CaP scaffolds, as summarized in Table 1. Furthermore, the compressive strength remarkably improved after heat-treatment at 33 °C for 3 h (Fig. 6 (b)), which was attributed to the achievement of well densified CaP frameworks. The aligned porous CaP scaffold produced with an initial CaP content of 25 vo% had a high compressive strength of 19.3 ± 2.7 MPa. It should be noted that porous CaP scaffolds with aligned pores can have much higher compressive strength than those with a random porous structure [34, 35].Fig. 6


Production of porous Calcium Phosphate (CaP) ceramics with aligned pores using ceramic/camphene-based co-extrusion.

Choi WY, Kim HE, Moon YW, Shin KH, Koh YH - Biomater Res (2015)

Compressive strengths of aligned porous CaP scaffolds produced without and with heat-treatment at 33 °C for 3 h (CaP contents: 15 vol%, 20 vol%, and 25 vol%). The compressive strengths between the samples are significantly different (p < 0.05)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4552288&req=5

Fig6: Compressive strengths of aligned porous CaP scaffolds produced without and with heat-treatment at 33 °C for 3 h (CaP contents: 15 vol%, 20 vol%, and 25 vol%). The compressive strengths between the samples are significantly different (p < 0.05)
Mentions: Compressive strength tests were conducted for the aligned porous CaP scaffolds produced with various CaP contents (15 vol%, 20 vol%, and 25 vol%), in order to evaluate their mechanical function as a bone scaffold. The compressive strength increased from 3.3 ± 0.42 MPa to 6.3 ± 0.57 MPa with increasing initial CaP content from 15 vol% 25 vol%, as shown in Fig. 6 (a). This improvement was mainly attributed to a decrease in the overall porosity of the aligned porous CaP scaffolds, as summarized in Table 1. Furthermore, the compressive strength remarkably improved after heat-treatment at 33 °C for 3 h (Fig. 6 (b)), which was attributed to the achievement of well densified CaP frameworks. The aligned porous CaP scaffold produced with an initial CaP content of 25 vo% had a high compressive strength of 19.3 ± 2.7 MPa. It should be noted that porous CaP scaffolds with aligned pores can have much higher compressive strength than those with a random porous structure [34, 35].Fig. 6

Bottom Line: Porous CaP ceramic scaffolds with aligned pores were successfully produced using ceramic/camphene-based co-extrusion.The porous CaP scaffolds showed excellent in vitro biocompatibility, suggesting their potential as the bone scaffold.Aligned porous CaP ceramic scaffolds with considerably enhanced mechanical properties and tailorable porosity would find very useful applications as the bone scaffold.

View Article: PubMed Central - PubMed

Affiliation: Department of Materials Science and Engineering, Seoul National University, Seoul, 151-742 Korea.

ABSTRACT

Background: Calcium phosphate (CaP) ceramics are one of the most valuable biomaterials for uses as the bone scaffold owing to their outstanding biocompatability, bioactivity, and biodegradation nature. In particular, these materials with an open porous structure can stimulate bone ingrowth into their 3-dimensionally interconnected pores. However, the creation of pores in bulk materials would inevitably cause a severe reduction in mechanical properties. Thus, it is a challenge to explore new ways of improving the mechanical properties of porous CaP scaffolds without scarifying their high porosity.

Results: Porous CaP ceramic scaffolds with aligned pores were successfully produced using ceramic/camphene-based co-extrusion. This aligned porous structure allowed for the achievement of high compressive strength when tested parallel to the direction of aligned pores. In addition, the overall porosity and mechanical properties of the aligned porous CaP ceramic scaffolds could be tailored simply by adjusting the initial CaP content in the CaP/camphene slurry. The porous CaP scaffolds showed excellent in vitro biocompatibility, suggesting their potential as the bone scaffold.

Conclusions: Aligned porous CaP ceramic scaffolds with considerably enhanced mechanical properties and tailorable porosity would find very useful applications as the bone scaffold.

No MeSH data available.