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Production of porous Calcium Phosphate (CaP) ceramics with aligned pores using ceramic/camphene-based co-extrusion.

Choi WY, Kim HE, Moon YW, Shin KH, Koh YH - Biomater Res (2015)

Bottom Line: Porous CaP ceramic scaffolds with aligned pores were successfully produced using ceramic/camphene-based co-extrusion.The porous CaP scaffolds showed excellent in vitro biocompatibility, suggesting their potential as the bone scaffold.Aligned porous CaP ceramic scaffolds with considerably enhanced mechanical properties and tailorable porosity would find very useful applications as the bone scaffold.

View Article: PubMed Central - PubMed

Affiliation: Department of Materials Science and Engineering, Seoul National University, Seoul, 151-742 Korea.

ABSTRACT

Background: Calcium phosphate (CaP) ceramics are one of the most valuable biomaterials for uses as the bone scaffold owing to their outstanding biocompatability, bioactivity, and biodegradation nature. In particular, these materials with an open porous structure can stimulate bone ingrowth into their 3-dimensionally interconnected pores. However, the creation of pores in bulk materials would inevitably cause a severe reduction in mechanical properties. Thus, it is a challenge to explore new ways of improving the mechanical properties of porous CaP scaffolds without scarifying their high porosity.

Results: Porous CaP ceramic scaffolds with aligned pores were successfully produced using ceramic/camphene-based co-extrusion. This aligned porous structure allowed for the achievement of high compressive strength when tested parallel to the direction of aligned pores. In addition, the overall porosity and mechanical properties of the aligned porous CaP ceramic scaffolds could be tailored simply by adjusting the initial CaP content in the CaP/camphene slurry. The porous CaP scaffolds showed excellent in vitro biocompatibility, suggesting their potential as the bone scaffold.

Conclusions: Aligned porous CaP ceramic scaffolds with considerably enhanced mechanical properties and tailorable porosity would find very useful applications as the bone scaffold.

No MeSH data available.


Pore sizes of aligned porous CaP scaffolds produced without and with heat-treatment at 33 °C for 3 h (CaP contents: 15 vol%, 20 vol%, and 25 vol%). The pore sizes between the samples are significantly different (p < 0.05)
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Fig5: Pore sizes of aligned porous CaP scaffolds produced without and with heat-treatment at 33 °C for 3 h (CaP contents: 15 vol%, 20 vol%, and 25 vol%). The pore sizes between the samples are significantly different (p < 0.05)

Mentions: The pore sizes of the aligned porous CaP scaffolds produced without and with heat-treatment at 33 °C for 3 h were calculated from their FE-SEM images, as shown in Fig. 5 (a) and (b). Both samples showed that the pore size decreased with increasing initial CaP content as is often the case with freeze casting [34, 35]. However, the pore size increased remarkably after heat-treatment at 33 °C for 3 h for all the samples. It should be noted that pores obtained using the present technique are 3-dimensionally interconnected, which would provide a favorable environment for bone ingrowth into pores [2].Fig 5


Production of porous Calcium Phosphate (CaP) ceramics with aligned pores using ceramic/camphene-based co-extrusion.

Choi WY, Kim HE, Moon YW, Shin KH, Koh YH - Biomater Res (2015)

Pore sizes of aligned porous CaP scaffolds produced without and with heat-treatment at 33 °C for 3 h (CaP contents: 15 vol%, 20 vol%, and 25 vol%). The pore sizes between the samples are significantly different (p < 0.05)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4552288&req=5

Fig5: Pore sizes of aligned porous CaP scaffolds produced without and with heat-treatment at 33 °C for 3 h (CaP contents: 15 vol%, 20 vol%, and 25 vol%). The pore sizes between the samples are significantly different (p < 0.05)
Mentions: The pore sizes of the aligned porous CaP scaffolds produced without and with heat-treatment at 33 °C for 3 h were calculated from their FE-SEM images, as shown in Fig. 5 (a) and (b). Both samples showed that the pore size decreased with increasing initial CaP content as is often the case with freeze casting [34, 35]. However, the pore size increased remarkably after heat-treatment at 33 °C for 3 h for all the samples. It should be noted that pores obtained using the present technique are 3-dimensionally interconnected, which would provide a favorable environment for bone ingrowth into pores [2].Fig 5

Bottom Line: Porous CaP ceramic scaffolds with aligned pores were successfully produced using ceramic/camphene-based co-extrusion.The porous CaP scaffolds showed excellent in vitro biocompatibility, suggesting their potential as the bone scaffold.Aligned porous CaP ceramic scaffolds with considerably enhanced mechanical properties and tailorable porosity would find very useful applications as the bone scaffold.

View Article: PubMed Central - PubMed

Affiliation: Department of Materials Science and Engineering, Seoul National University, Seoul, 151-742 Korea.

ABSTRACT

Background: Calcium phosphate (CaP) ceramics are one of the most valuable biomaterials for uses as the bone scaffold owing to their outstanding biocompatability, bioactivity, and biodegradation nature. In particular, these materials with an open porous structure can stimulate bone ingrowth into their 3-dimensionally interconnected pores. However, the creation of pores in bulk materials would inevitably cause a severe reduction in mechanical properties. Thus, it is a challenge to explore new ways of improving the mechanical properties of porous CaP scaffolds without scarifying their high porosity.

Results: Porous CaP ceramic scaffolds with aligned pores were successfully produced using ceramic/camphene-based co-extrusion. This aligned porous structure allowed for the achievement of high compressive strength when tested parallel to the direction of aligned pores. In addition, the overall porosity and mechanical properties of the aligned porous CaP ceramic scaffolds could be tailored simply by adjusting the initial CaP content in the CaP/camphene slurry. The porous CaP scaffolds showed excellent in vitro biocompatibility, suggesting their potential as the bone scaffold.

Conclusions: Aligned porous CaP ceramic scaffolds with considerably enhanced mechanical properties and tailorable porosity would find very useful applications as the bone scaffold.

No MeSH data available.