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Genetic association between TRAIL-R1 Thr209Arg and cancer susceptibility.

Geng P, Li J, Wang N, Liao Y, Ou J, Sa R, Xie G, Liu C, Li H, Xiang L, Liang H - Sci Rep (2015)

Bottom Line: We aimed to determine the indecisive association between tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) Thr209Arg polymorphism and inherited susceptibility to cancer.A meta-analysis combining data on 9,517 individuals was performed to assess the association between TRAIL-R1 Thr209Arg and cancer incidence.The summary ORs with 95% CI calculated with the fixed effects model suggested that Thr209Arg was not significantly associated with cancer susceptibility (homozygous model: OR 0.98, 95% CI 0.88-1.09; heterozygous model: OR 0.95, 95% CI 0.87-1.04; allele frequency model: OR 0.99, 95% CI 0.94-1.05; dominant model: OR 0.98, 95% CI 0.91-1.05; recessive model: OR 1.01, 95% CI 0.92-1.10).

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, 29 Gaotanyan Main Street, Chongqing 400038, China.

ABSTRACT
We aimed to determine the indecisive association between tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) Thr209Arg polymorphism and inherited susceptibility to cancer. A meta-analysis combining data on 9,517 individuals was performed to assess the association between TRAIL-R1 Thr209Arg and cancer incidence. The summary ORs with 95% CI calculated with the fixed effects model suggested that Thr209Arg was not significantly associated with cancer susceptibility (homozygous model: OR 0.98, 95% CI 0.88-1.09; heterozygous model: OR 0.95, 95% CI 0.87-1.04; allele frequency model: OR 0.99, 95% CI 0.94-1.05; dominant model: OR 0.98, 95% CI 0.91-1.05; recessive model: OR 1.01, 95% CI 0.92-1.10). Stratified analysis by ethnicity and cancer type yielded similar associations. These statistical data suggest that Thr209Arg in exon 4 of the TRAIL-R1 gene may not represent a modifier of susceptibility to cancer.

No MeSH data available.


Related in: MedlinePlus

Flow diagram of study selection for meta-analysis.
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f1: Flow diagram of study selection for meta-analysis.

Mentions: We retrieved a total of 952 records matching pre-listed keywords. Title and abstract evaluation led to an elimination of 891 records. We then read the full text of all 61 articles and found 32 articles reported an association unrelated to the polymorphism being examined, 8 articles offered insufficient raw data, 4 articles were systematic reviews and 1 was case-only designed. After discarding all useless records, we at last included 16 articles13141522232425262728293031323334 (Fig. 1). Genotype and allele frequencies, along with main characteristics of the studies involved in this meta-analysis are detailed in Table 1. According to Table 1, breast cancer was the most studied cancer type, followed by lung cancer. Other cancers, such as cancers of bladder, hematological, gastric, ovarian, colorectal, liver and gallbladder were relatively less investigated and thereby merged into “other” category when performing meta-analysis. Caucasian and Asian ethnicities were all investigated, with Caucasian individuals outnumbering Asians. The genotype frequencies of Kuraoka et al. (2005) and Mittal et al. (2011) in control population were not in HWE, according to χ2 test.


Genetic association between TRAIL-R1 Thr209Arg and cancer susceptibility.

Geng P, Li J, Wang N, Liao Y, Ou J, Sa R, Xie G, Liu C, Li H, Xiang L, Liang H - Sci Rep (2015)

Flow diagram of study selection for meta-analysis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4551968&req=5

f1: Flow diagram of study selection for meta-analysis.
Mentions: We retrieved a total of 952 records matching pre-listed keywords. Title and abstract evaluation led to an elimination of 891 records. We then read the full text of all 61 articles and found 32 articles reported an association unrelated to the polymorphism being examined, 8 articles offered insufficient raw data, 4 articles were systematic reviews and 1 was case-only designed. After discarding all useless records, we at last included 16 articles13141522232425262728293031323334 (Fig. 1). Genotype and allele frequencies, along with main characteristics of the studies involved in this meta-analysis are detailed in Table 1. According to Table 1, breast cancer was the most studied cancer type, followed by lung cancer. Other cancers, such as cancers of bladder, hematological, gastric, ovarian, colorectal, liver and gallbladder were relatively less investigated and thereby merged into “other” category when performing meta-analysis. Caucasian and Asian ethnicities were all investigated, with Caucasian individuals outnumbering Asians. The genotype frequencies of Kuraoka et al. (2005) and Mittal et al. (2011) in control population were not in HWE, according to χ2 test.

Bottom Line: We aimed to determine the indecisive association between tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) Thr209Arg polymorphism and inherited susceptibility to cancer.A meta-analysis combining data on 9,517 individuals was performed to assess the association between TRAIL-R1 Thr209Arg and cancer incidence.The summary ORs with 95% CI calculated with the fixed effects model suggested that Thr209Arg was not significantly associated with cancer susceptibility (homozygous model: OR 0.98, 95% CI 0.88-1.09; heterozygous model: OR 0.95, 95% CI 0.87-1.04; allele frequency model: OR 0.99, 95% CI 0.94-1.05; dominant model: OR 0.98, 95% CI 0.91-1.05; recessive model: OR 1.01, 95% CI 0.92-1.10).

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, 29 Gaotanyan Main Street, Chongqing 400038, China.

ABSTRACT
We aimed to determine the indecisive association between tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) Thr209Arg polymorphism and inherited susceptibility to cancer. A meta-analysis combining data on 9,517 individuals was performed to assess the association between TRAIL-R1 Thr209Arg and cancer incidence. The summary ORs with 95% CI calculated with the fixed effects model suggested that Thr209Arg was not significantly associated with cancer susceptibility (homozygous model: OR 0.98, 95% CI 0.88-1.09; heterozygous model: OR 0.95, 95% CI 0.87-1.04; allele frequency model: OR 0.99, 95% CI 0.94-1.05; dominant model: OR 0.98, 95% CI 0.91-1.05; recessive model: OR 1.01, 95% CI 0.92-1.10). Stratified analysis by ethnicity and cancer type yielded similar associations. These statistical data suggest that Thr209Arg in exon 4 of the TRAIL-R1 gene may not represent a modifier of susceptibility to cancer.

No MeSH data available.


Related in: MedlinePlus