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Allium sativum L. Improves Visual Memory and Attention in Healthy Human Volunteers.

Tasnim S, Haque PS, Bari MS, Hossain MM, Islam SM, Shahriar M, Bhuiyan MA, Bin Sayeed MS - Evid Based Complement Alternat Med (2015)

Bottom Line: We found statistically significant difference (p < 0.05) in several parameters of visual memory and attention due to AS ingestion.We also found statistically nonsignificant (p > 0.05) beneficial effects on verbal memory and executive function within a short period of time among the volunteers.Study for a longer period of time with patients suffering from neurodegenerative diseases might yield more relevant results regarding the potential therapeutic role of AS.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.

ABSTRACT
Studies have shown that Allium sativum L. (AS) protects amyloid-beta peptide-induced apoptosis, prevents oxidative insults to neurons and synapses, and thus prevent Alzheimer's disease progression in experimental animals. However, there is no experimental evidence in human regarding its putative role in memory and cognition. We have studied the effect of AS consumption by healthy human volunteers on visual memory, verbal memory, attention, and executive function in comparison to control subjects taking placebo. The study was conducted over five weeks and twenty volunteers of both genders were recruited and divided randomly into two groups: A (AS) and B (placebo). Both groups participated in the 6 computerized neuropsychological tests of the Cambridge Neuropsychological Test Automated Battery (CANTAB) twice: at the beginning and after five weeks of the study. We found statistically significant difference (p < 0.05) in several parameters of visual memory and attention due to AS ingestion. We also found statistically nonsignificant (p > 0.05) beneficial effects on verbal memory and executive function within a short period of time among the volunteers. Study for a longer period of time with patients suffering from neurodegenerative diseases might yield more relevant results regarding the potential therapeutic role of AS.

No MeSH data available.


Related in: MedlinePlus

CONSORT 2010 flow diagram for the study design.
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Related In: Results  -  Collection


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fig1: CONSORT 2010 flow diagram for the study design.

Mentions: The study was conducted over five weeks. Volunteers were randomly divided into two groups (Figure 1). One group (group A) received one 400 mg AS capsule twice daily in the morning and the evening for five weeks. The dose was selected based on previous reports [24–26]. The second group (group B) received placebo in a similar manner for the same period of time. Placebo and garlic capsules had the same color, texture, size, shape, and smell. All the volunteers were assessed for baseline data to measure the condition of memory, attentiveness, and cognition before the administration of the first dose of either AS capsules or placebo. The sequences of the tests administered were kept constant for all the volunteers and were completed between 1400 and 1700 h. The volunteers were assessed for all the parameters measured at two time points: baseline and after the fifth week of capsule administration. The instructions for the tests were explained to the volunteers before conducting the study. All volunteers were kept blind about garlic or placebo and the code numbers and the group allocation were only revealed after the assessment of the last subject. All volunteers were instructed to call the study center in case of any adverse effect during the study. Volunteers had the opportunity to withdraw from the study at any time. All the volunteers were contacted at definite intervals to ensure that they took the capsules regularly.


Allium sativum L. Improves Visual Memory and Attention in Healthy Human Volunteers.

Tasnim S, Haque PS, Bari MS, Hossain MM, Islam SM, Shahriar M, Bhuiyan MA, Bin Sayeed MS - Evid Based Complement Alternat Med (2015)

CONSORT 2010 flow diagram for the study design.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4550798&req=5

fig1: CONSORT 2010 flow diagram for the study design.
Mentions: The study was conducted over five weeks. Volunteers were randomly divided into two groups (Figure 1). One group (group A) received one 400 mg AS capsule twice daily in the morning and the evening for five weeks. The dose was selected based on previous reports [24–26]. The second group (group B) received placebo in a similar manner for the same period of time. Placebo and garlic capsules had the same color, texture, size, shape, and smell. All the volunteers were assessed for baseline data to measure the condition of memory, attentiveness, and cognition before the administration of the first dose of either AS capsules or placebo. The sequences of the tests administered were kept constant for all the volunteers and were completed between 1400 and 1700 h. The volunteers were assessed for all the parameters measured at two time points: baseline and after the fifth week of capsule administration. The instructions for the tests were explained to the volunteers before conducting the study. All volunteers were kept blind about garlic or placebo and the code numbers and the group allocation were only revealed after the assessment of the last subject. All volunteers were instructed to call the study center in case of any adverse effect during the study. Volunteers had the opportunity to withdraw from the study at any time. All the volunteers were contacted at definite intervals to ensure that they took the capsules regularly.

Bottom Line: We found statistically significant difference (p < 0.05) in several parameters of visual memory and attention due to AS ingestion.We also found statistically nonsignificant (p > 0.05) beneficial effects on verbal memory and executive function within a short period of time among the volunteers.Study for a longer period of time with patients suffering from neurodegenerative diseases might yield more relevant results regarding the potential therapeutic role of AS.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.

ABSTRACT
Studies have shown that Allium sativum L. (AS) protects amyloid-beta peptide-induced apoptosis, prevents oxidative insults to neurons and synapses, and thus prevent Alzheimer's disease progression in experimental animals. However, there is no experimental evidence in human regarding its putative role in memory and cognition. We have studied the effect of AS consumption by healthy human volunteers on visual memory, verbal memory, attention, and executive function in comparison to control subjects taking placebo. The study was conducted over five weeks and twenty volunteers of both genders were recruited and divided randomly into two groups: A (AS) and B (placebo). Both groups participated in the 6 computerized neuropsychological tests of the Cambridge Neuropsychological Test Automated Battery (CANTAB) twice: at the beginning and after five weeks of the study. We found statistically significant difference (p < 0.05) in several parameters of visual memory and attention due to AS ingestion. We also found statistically nonsignificant (p > 0.05) beneficial effects on verbal memory and executive function within a short period of time among the volunteers. Study for a longer period of time with patients suffering from neurodegenerative diseases might yield more relevant results regarding the potential therapeutic role of AS.

No MeSH data available.


Related in: MedlinePlus