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Synthesis and Properties of pH-, Thermo-, and Salt-Sensitive Modified Poly(aspartic acid)/Poly(vinyl alcohol) IPN Hydrogel and Its Drug Controlled Release.

Lu J, Li Y, Hu D, Chen X, Liu Y, Wang L, Zhao Y - Biomed Res Int (2015)

Bottom Line: The thermal stability was analyzed by thermogravimetric analysis (TGA).Finally, the drug controlled release properties of the three hydrogels were evaluated and results indicated that three hydrogels could control drug release by external surroundings stimuli.These results indicated that KPAsp/PVA IPN hydrogels are a promising carrier system for controlled drug delivery.

View Article: PubMed Central - PubMed

Affiliation: School of Chemical and Biological Engineering, Taiyuan University of Science and Technology, Taiyuan 030024, China ; College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.

ABSTRACT
Modified poly(aspartic acid)/poly(vinyl alcohol) interpenetrating polymer network (KPAsp/PVA IPN) hydrogel for drug controlled release was synthesized by a simple one-step method in aqueous system using poly(aspartic acid) grafting 3-aminopropyltriethoxysilane (KH-550) and poly(vinyl alcohol) (PVA) as materials. The hydrogel surface morphology and composition were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The thermal stability was analyzed by thermogravimetric analysis (TGA). The swelling properties and pH, temperature, and salt sensitivities of KPAsp, KPAsp/PVA semi-interpenetrating polymer network (semi-IPN), and KPAsp/PVA IPN hydrogels were also investigated. All of the three hydrogels showed ampholytic pH-responsive properties, and swelling behavior was also extremely sensitive to the temperature, ionic strength, and cationic species. Finally, the drug controlled release properties of the three hydrogels were evaluated and results indicated that three hydrogels could control drug release by external surroundings stimuli. The drug controlled release properties of KPAsp/PVA IPN hydrogel are the most outstanding, and the correlative measured release profiles of salicylic acid at 37°C were 32.6 wt% at pH = 1.2 (simulated gastric fluid) and 62.5 wt% at pH = 7.4 (simulated intestinal fluid), respectively. These results indicated that KPAsp/PVA IPN hydrogels are a promising carrier system for controlled drug delivery.

No MeSH data available.


Related in: MedlinePlus

Release behavior of KPAsp, KPAsp/PVA semi-IPN, and KPAsp/PVA IPN hydrogels in pH values at 1.2 (a) and 7.4 (b).
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fig9: Release behavior of KPAsp, KPAsp/PVA semi-IPN, and KPAsp/PVA IPN hydrogels in pH values at 1.2 (a) and 7.4 (b).

Mentions: Figure 9 presented the release profiles of salicylic acid from the three hydrogels at pH values of 1.2 (simulated gastric fluid) and 7.4 (simulated intestinal fluid) at 37°C. As clearly shown in Figure 9, all the hydrogels can be observed with significant pH-dependent response. The drug release of each hydrogel in pH values of 1.2 was obviously slower than that in pH values of 7.4. In addition, the release rate of salicylic acid from the KPAsp/PVA IPN hydrogel is always the highest among the three hydrogels, which should be related to the IPN structure with increased porous structure and specific surface area [42]. The corresponding cumulative amounts of salicylic acid released from the KPAsp/PVA IPN hydrogel were 32.6% at pH 1.2, while the cumulative release rate reached 62.5% at pH 7.4. That may be ascribed to the increase of –OH on the hydrogel with the PVA introduction. In acid environment carboxyl groups on the IPN hydrogel are in the form of –COOH, and the effect of H-bonding between these –COOH and –OH limits the release of salicylic acid. As the pH value increases, carboxyl groups on the IPN hydrogel incline to form –COONa, and the effect of H-bonding between –COOH and –OH recedes; therefore salicylic acid becomes easy release from the hydrogel. In conclusion, this novel IPN hydrogel can control drug release by external surroundings stimuli and has a relative high drug release rate in simulated intestinal fluid.


Synthesis and Properties of pH-, Thermo-, and Salt-Sensitive Modified Poly(aspartic acid)/Poly(vinyl alcohol) IPN Hydrogel and Its Drug Controlled Release.

Lu J, Li Y, Hu D, Chen X, Liu Y, Wang L, Zhao Y - Biomed Res Int (2015)

Release behavior of KPAsp, KPAsp/PVA semi-IPN, and KPAsp/PVA IPN hydrogels in pH values at 1.2 (a) and 7.4 (b).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4550758&req=5

fig9: Release behavior of KPAsp, KPAsp/PVA semi-IPN, and KPAsp/PVA IPN hydrogels in pH values at 1.2 (a) and 7.4 (b).
Mentions: Figure 9 presented the release profiles of salicylic acid from the three hydrogels at pH values of 1.2 (simulated gastric fluid) and 7.4 (simulated intestinal fluid) at 37°C. As clearly shown in Figure 9, all the hydrogels can be observed with significant pH-dependent response. The drug release of each hydrogel in pH values of 1.2 was obviously slower than that in pH values of 7.4. In addition, the release rate of salicylic acid from the KPAsp/PVA IPN hydrogel is always the highest among the three hydrogels, which should be related to the IPN structure with increased porous structure and specific surface area [42]. The corresponding cumulative amounts of salicylic acid released from the KPAsp/PVA IPN hydrogel were 32.6% at pH 1.2, while the cumulative release rate reached 62.5% at pH 7.4. That may be ascribed to the increase of –OH on the hydrogel with the PVA introduction. In acid environment carboxyl groups on the IPN hydrogel are in the form of –COOH, and the effect of H-bonding between these –COOH and –OH limits the release of salicylic acid. As the pH value increases, carboxyl groups on the IPN hydrogel incline to form –COONa, and the effect of H-bonding between –COOH and –OH recedes; therefore salicylic acid becomes easy release from the hydrogel. In conclusion, this novel IPN hydrogel can control drug release by external surroundings stimuli and has a relative high drug release rate in simulated intestinal fluid.

Bottom Line: The thermal stability was analyzed by thermogravimetric analysis (TGA).Finally, the drug controlled release properties of the three hydrogels were evaluated and results indicated that three hydrogels could control drug release by external surroundings stimuli.These results indicated that KPAsp/PVA IPN hydrogels are a promising carrier system for controlled drug delivery.

View Article: PubMed Central - PubMed

Affiliation: School of Chemical and Biological Engineering, Taiyuan University of Science and Technology, Taiyuan 030024, China ; College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.

ABSTRACT
Modified poly(aspartic acid)/poly(vinyl alcohol) interpenetrating polymer network (KPAsp/PVA IPN) hydrogel for drug controlled release was synthesized by a simple one-step method in aqueous system using poly(aspartic acid) grafting 3-aminopropyltriethoxysilane (KH-550) and poly(vinyl alcohol) (PVA) as materials. The hydrogel surface morphology and composition were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The thermal stability was analyzed by thermogravimetric analysis (TGA). The swelling properties and pH, temperature, and salt sensitivities of KPAsp, KPAsp/PVA semi-interpenetrating polymer network (semi-IPN), and KPAsp/PVA IPN hydrogels were also investigated. All of the three hydrogels showed ampholytic pH-responsive properties, and swelling behavior was also extremely sensitive to the temperature, ionic strength, and cationic species. Finally, the drug controlled release properties of the three hydrogels were evaluated and results indicated that three hydrogels could control drug release by external surroundings stimuli. The drug controlled release properties of KPAsp/PVA IPN hydrogel are the most outstanding, and the correlative measured release profiles of salicylic acid at 37°C were 32.6 wt% at pH = 1.2 (simulated gastric fluid) and 62.5 wt% at pH = 7.4 (simulated intestinal fluid), respectively. These results indicated that KPAsp/PVA IPN hydrogels are a promising carrier system for controlled drug delivery.

No MeSH data available.


Related in: MedlinePlus