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Synthesis and Properties of pH-, Thermo-, and Salt-Sensitive Modified Poly(aspartic acid)/Poly(vinyl alcohol) IPN Hydrogel and Its Drug Controlled Release.

Lu J, Li Y, Hu D, Chen X, Liu Y, Wang L, Zhao Y - Biomed Res Int (2015)

Bottom Line: The thermal stability was analyzed by thermogravimetric analysis (TGA).Finally, the drug controlled release properties of the three hydrogels were evaluated and results indicated that three hydrogels could control drug release by external surroundings stimuli.These results indicated that KPAsp/PVA IPN hydrogels are a promising carrier system for controlled drug delivery.

View Article: PubMed Central - PubMed

Affiliation: School of Chemical and Biological Engineering, Taiyuan University of Science and Technology, Taiyuan 030024, China ; College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.

ABSTRACT
Modified poly(aspartic acid)/poly(vinyl alcohol) interpenetrating polymer network (KPAsp/PVA IPN) hydrogel for drug controlled release was synthesized by a simple one-step method in aqueous system using poly(aspartic acid) grafting 3-aminopropyltriethoxysilane (KH-550) and poly(vinyl alcohol) (PVA) as materials. The hydrogel surface morphology and composition were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The thermal stability was analyzed by thermogravimetric analysis (TGA). The swelling properties and pH, temperature, and salt sensitivities of KPAsp, KPAsp/PVA semi-interpenetrating polymer network (semi-IPN), and KPAsp/PVA IPN hydrogels were also investigated. All of the three hydrogels showed ampholytic pH-responsive properties, and swelling behavior was also extremely sensitive to the temperature, ionic strength, and cationic species. Finally, the drug controlled release properties of the three hydrogels were evaluated and results indicated that three hydrogels could control drug release by external surroundings stimuli. The drug controlled release properties of KPAsp/PVA IPN hydrogel are the most outstanding, and the correlative measured release profiles of salicylic acid at 37°C were 32.6 wt% at pH = 1.2 (simulated gastric fluid) and 62.5 wt% at pH = 7.4 (simulated intestinal fluid), respectively. These results indicated that KPAsp/PVA IPN hydrogels are a promising carrier system for controlled drug delivery.

No MeSH data available.


Related in: MedlinePlus

Swelling ratio of KPAsp, KPAsp/PVA semi-IPN, and KPAsp/PVA IPN hydrogels with the variation of temperature.
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Related In: Results  -  Collection


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fig7: Swelling ratio of KPAsp, KPAsp/PVA semi-IPN, and KPAsp/PVA IPN hydrogels with the variation of temperature.

Mentions: Temperature is an important environmental factor to appraise a hydrogel. Figure 7 depicts the temperature-dependent swelling of KPAsp, KPAsp/PVA semi-IPN, and KPAsp/PVA IPN hydrogels in a temperature range of 25 to 65°C. It can be seen that the swelling ratio was firstly increased with the increasing temperature and then fell down quickly, indicating that all hydrogels were thermosensitive. The temperature of optimum swelling ratio for all samples was 40°C. The swelling ratio of semi-IPN and IPN hydrogels was always higher than that of KPAsp hydrogel.


Synthesis and Properties of pH-, Thermo-, and Salt-Sensitive Modified Poly(aspartic acid)/Poly(vinyl alcohol) IPN Hydrogel and Its Drug Controlled Release.

Lu J, Li Y, Hu D, Chen X, Liu Y, Wang L, Zhao Y - Biomed Res Int (2015)

Swelling ratio of KPAsp, KPAsp/PVA semi-IPN, and KPAsp/PVA IPN hydrogels with the variation of temperature.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4550758&req=5

fig7: Swelling ratio of KPAsp, KPAsp/PVA semi-IPN, and KPAsp/PVA IPN hydrogels with the variation of temperature.
Mentions: Temperature is an important environmental factor to appraise a hydrogel. Figure 7 depicts the temperature-dependent swelling of KPAsp, KPAsp/PVA semi-IPN, and KPAsp/PVA IPN hydrogels in a temperature range of 25 to 65°C. It can be seen that the swelling ratio was firstly increased with the increasing temperature and then fell down quickly, indicating that all hydrogels were thermosensitive. The temperature of optimum swelling ratio for all samples was 40°C. The swelling ratio of semi-IPN and IPN hydrogels was always higher than that of KPAsp hydrogel.

Bottom Line: The thermal stability was analyzed by thermogravimetric analysis (TGA).Finally, the drug controlled release properties of the three hydrogels were evaluated and results indicated that three hydrogels could control drug release by external surroundings stimuli.These results indicated that KPAsp/PVA IPN hydrogels are a promising carrier system for controlled drug delivery.

View Article: PubMed Central - PubMed

Affiliation: School of Chemical and Biological Engineering, Taiyuan University of Science and Technology, Taiyuan 030024, China ; College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.

ABSTRACT
Modified poly(aspartic acid)/poly(vinyl alcohol) interpenetrating polymer network (KPAsp/PVA IPN) hydrogel for drug controlled release was synthesized by a simple one-step method in aqueous system using poly(aspartic acid) grafting 3-aminopropyltriethoxysilane (KH-550) and poly(vinyl alcohol) (PVA) as materials. The hydrogel surface morphology and composition were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The thermal stability was analyzed by thermogravimetric analysis (TGA). The swelling properties and pH, temperature, and salt sensitivities of KPAsp, KPAsp/PVA semi-interpenetrating polymer network (semi-IPN), and KPAsp/PVA IPN hydrogels were also investigated. All of the three hydrogels showed ampholytic pH-responsive properties, and swelling behavior was also extremely sensitive to the temperature, ionic strength, and cationic species. Finally, the drug controlled release properties of the three hydrogels were evaluated and results indicated that three hydrogels could control drug release by external surroundings stimuli. The drug controlled release properties of KPAsp/PVA IPN hydrogel are the most outstanding, and the correlative measured release profiles of salicylic acid at 37°C were 32.6 wt% at pH = 1.2 (simulated gastric fluid) and 62.5 wt% at pH = 7.4 (simulated intestinal fluid), respectively. These results indicated that KPAsp/PVA IPN hydrogels are a promising carrier system for controlled drug delivery.

No MeSH data available.


Related in: MedlinePlus