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Human Neutrophil Lipocalin as a Superior Diagnostic Means To Distinguish between Acute Bacterial and Viral Infections.

Venge P, Douhan-HÃ¥kansson L, Garwicz D, Peterson C, Xu S, Pauksen K - Clin. Vaccine Immunol. (2015)

Bottom Line: In the distinction between healthy controls and patients with bacterial infections, the areas under the receiver operating characteristic (ROC) curves were >0.85 for all biomarkers, whereas for the distinction between bacterial and viral infections, only HNL concentration in fMLP-activated whole blood showed an area under the ROC curve (AUROC) of >0.90 and superior clinical performance.The clinical performance of HNL in fMLP-activated whole blood was superior to current biomarkers and similar to previous results of HNL in serum.The procedure can be adopted for point-of-care testing with response times of <15 min.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Sciences, Section of Clinical Chemistry, Uppsala University, Uppsala, Sweden per.venge@medsci.uu.se.

No MeSH data available.


Related in: MedlinePlus

Receiver operating characteristic curves of B-HNL, expression of CD64 on PMN, and plasma PCT (P-PCT) in the discrimination between healthy noninfected subjects and patients with bacterial infections (top), and between patients with bacterial and viral infections (bottom). The areas under ROC curve results are summarized in Table 3.
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Figure 3: Receiver operating characteristic curves of B-HNL, expression of CD64 on PMN, and plasma PCT (P-PCT) in the discrimination between healthy noninfected subjects and patients with bacterial infections (top), and between patients with bacterial and viral infections (bottom). The areas under ROC curve results are summarized in Table 3.

Mentions: Figure 3 shows the comparisons of the clinical performance of the three studied biomarkers. The areas under the ROC curves (AUROCs) are given in Table 3. In the distinction between healthy and bacterial infections, two biomarkers showed AUROCs of >90%, and these were B-HNL and the expression of CD64 on blood neutrophils. The AUROC of B-HNL was significantly higher than the AUROC of procalcitonin (P = 0.02), and the AUROC of the expression of CD64 on neutrophils was higher than that for PCT (P = 0.03).


Human Neutrophil Lipocalin as a Superior Diagnostic Means To Distinguish between Acute Bacterial and Viral Infections.

Venge P, Douhan-HÃ¥kansson L, Garwicz D, Peterson C, Xu S, Pauksen K - Clin. Vaccine Immunol. (2015)

Receiver operating characteristic curves of B-HNL, expression of CD64 on PMN, and plasma PCT (P-PCT) in the discrimination between healthy noninfected subjects and patients with bacterial infections (top), and between patients with bacterial and viral infections (bottom). The areas under ROC curve results are summarized in Table 3.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4550662&req=5

Figure 3: Receiver operating characteristic curves of B-HNL, expression of CD64 on PMN, and plasma PCT (P-PCT) in the discrimination between healthy noninfected subjects and patients with bacterial infections (top), and between patients with bacterial and viral infections (bottom). The areas under ROC curve results are summarized in Table 3.
Mentions: Figure 3 shows the comparisons of the clinical performance of the three studied biomarkers. The areas under the ROC curves (AUROCs) are given in Table 3. In the distinction between healthy and bacterial infections, two biomarkers showed AUROCs of >90%, and these were B-HNL and the expression of CD64 on blood neutrophils. The AUROC of B-HNL was significantly higher than the AUROC of procalcitonin (P = 0.02), and the AUROC of the expression of CD64 on neutrophils was higher than that for PCT (P = 0.03).

Bottom Line: In the distinction between healthy controls and patients with bacterial infections, the areas under the receiver operating characteristic (ROC) curves were >0.85 for all biomarkers, whereas for the distinction between bacterial and viral infections, only HNL concentration in fMLP-activated whole blood showed an area under the ROC curve (AUROC) of >0.90 and superior clinical performance.The clinical performance of HNL in fMLP-activated whole blood was superior to current biomarkers and similar to previous results of HNL in serum.The procedure can be adopted for point-of-care testing with response times of <15 min.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Sciences, Section of Clinical Chemistry, Uppsala University, Uppsala, Sweden per.venge@medsci.uu.se.

No MeSH data available.


Related in: MedlinePlus