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Antitumor Activity of Doxorubicin-Loaded Carbon Nanotubes Incorporated Poly(Lactic-Co-Glycolic Acid) Electrospun Composite Nanofibers.

Yu Y, Kong L, Li L, Li N, Yan P - Nanoscale Res Lett (2015)

Bottom Line: The properties of the prepared composite nanofibrous mats were characterized by various techniques.The results showed that DOX-loaded CNTs can be readily incorporated into the nanofibers with relatively uniform distribution within the nanofibers.More importantly, the drug from the composite nanofibers can be released in a sustained and prolonged manner, and thereby, a significant antitumor efficacy in vitro is obtained.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai, Shandong, 264003, People's Republic of China.

ABSTRACT
The drug-loaded composite electrospun nanofiber has attracted more attention in biomedical field, especially in cancer therapy. In this study, a composite nanofiber was fabricated by electrospinning for cancer treatment. Firstly, the carbon nanotubes (CNTs) were selected as carriers to load the anticancer drug-doxorubicin (DOX) hydrochloride. Secondly, the DOX-loaded CNTs (DOX@CNTs) were incorporated into the poly(lactic-co-glycolic acid) (PLGA) nanofibers via electrospinning. Finally, a new drug-loaded nanofibrous scaffold (PLGA/DOX@CNTs) was formed. The properties of the prepared composite nanofibrous mats were characterized by various techniques. The release profiles of the different DOX-loaded nanofibers were measured, and the in vitro antitumor efficacy against HeLa cells was also evaluated. The results showed that DOX-loaded CNTs can be readily incorporated into the nanofibers with relatively uniform distribution within the nanofibers. More importantly, the drug from the composite nanofibers can be released in a sustained and prolonged manner, and thereby, a significant antitumor efficacy in vitro is obtained. Thus, the prepared composite nanofibrous mats are a promising alternative for cancer treatment.

No MeSH data available.


Typical tensile stress-strain curves of electrospun PLGA nanofibers, PLGA/0.5 % CNTs, PLGA/1 % CNTs, and PLGA/2 % CNTs composite nanofibers
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Fig3: Typical tensile stress-strain curves of electrospun PLGA nanofibers, PLGA/0.5 % CNTs, PLGA/1 % CNTs, and PLGA/2 % CNTs composite nanofibers

Mentions: Figure 3 shows the typical tensile strain-stress curves of neat PLGA and the PLGA/CNTs composite nanofibers with different CNTs contents. The mechanical properties of these nanofibers are summarized in Table 1. It can be found that the addition of CNTs affected the mechanical properties of the composite nanofibers, whose tensile strength, elongation at break, and Young’s modulus were smaller than that of the neat PLGA nanofibers. This tendency was similar with the mesoporous silica nanoparticles-embedded nanofibers, which may result from the aggregation of CNTs in hybrid nanofibers and poor interfacial adhesion between the CNTs and the PLGA matrix [22]. Furthermore, among the composite nanofibers, the tensile strength increased with the increasing of CNTs contents, which was basically in agreement with the data of the elongation at break. However, the Young’s modulus of PLGA/1 % CNTs was greater than that of the other composite nanofibers. For example, the Young’s modulus for composite nanofibers with 1 % of CNTs content was 145.53 MPa as compared to 76.50 MPa for PLGA/1 % CNTs and 142.25 MPa for PLGA/2 % CNTs nanofibers.Fig. 3


Antitumor Activity of Doxorubicin-Loaded Carbon Nanotubes Incorporated Poly(Lactic-Co-Glycolic Acid) Electrospun Composite Nanofibers.

Yu Y, Kong L, Li L, Li N, Yan P - Nanoscale Res Lett (2015)

Typical tensile stress-strain curves of electrospun PLGA nanofibers, PLGA/0.5 % CNTs, PLGA/1 % CNTs, and PLGA/2 % CNTs composite nanofibers
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4549354&req=5

Fig3: Typical tensile stress-strain curves of electrospun PLGA nanofibers, PLGA/0.5 % CNTs, PLGA/1 % CNTs, and PLGA/2 % CNTs composite nanofibers
Mentions: Figure 3 shows the typical tensile strain-stress curves of neat PLGA and the PLGA/CNTs composite nanofibers with different CNTs contents. The mechanical properties of these nanofibers are summarized in Table 1. It can be found that the addition of CNTs affected the mechanical properties of the composite nanofibers, whose tensile strength, elongation at break, and Young’s modulus were smaller than that of the neat PLGA nanofibers. This tendency was similar with the mesoporous silica nanoparticles-embedded nanofibers, which may result from the aggregation of CNTs in hybrid nanofibers and poor interfacial adhesion between the CNTs and the PLGA matrix [22]. Furthermore, among the composite nanofibers, the tensile strength increased with the increasing of CNTs contents, which was basically in agreement with the data of the elongation at break. However, the Young’s modulus of PLGA/1 % CNTs was greater than that of the other composite nanofibers. For example, the Young’s modulus for composite nanofibers with 1 % of CNTs content was 145.53 MPa as compared to 76.50 MPa for PLGA/1 % CNTs and 142.25 MPa for PLGA/2 % CNTs nanofibers.Fig. 3

Bottom Line: The properties of the prepared composite nanofibrous mats were characterized by various techniques.The results showed that DOX-loaded CNTs can be readily incorporated into the nanofibers with relatively uniform distribution within the nanofibers.More importantly, the drug from the composite nanofibers can be released in a sustained and prolonged manner, and thereby, a significant antitumor efficacy in vitro is obtained.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai, Shandong, 264003, People's Republic of China.

ABSTRACT
The drug-loaded composite electrospun nanofiber has attracted more attention in biomedical field, especially in cancer therapy. In this study, a composite nanofiber was fabricated by electrospinning for cancer treatment. Firstly, the carbon nanotubes (CNTs) were selected as carriers to load the anticancer drug-doxorubicin (DOX) hydrochloride. Secondly, the DOX-loaded CNTs (DOX@CNTs) were incorporated into the poly(lactic-co-glycolic acid) (PLGA) nanofibers via electrospinning. Finally, a new drug-loaded nanofibrous scaffold (PLGA/DOX@CNTs) was formed. The properties of the prepared composite nanofibrous mats were characterized by various techniques. The release profiles of the different DOX-loaded nanofibers were measured, and the in vitro antitumor efficacy against HeLa cells was also evaluated. The results showed that DOX-loaded CNTs can be readily incorporated into the nanofibers with relatively uniform distribution within the nanofibers. More importantly, the drug from the composite nanofibers can be released in a sustained and prolonged manner, and thereby, a significant antitumor efficacy in vitro is obtained. Thus, the prepared composite nanofibrous mats are a promising alternative for cancer treatment.

No MeSH data available.