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Antitumor Activity of Doxorubicin-Loaded Carbon Nanotubes Incorporated Poly(Lactic-Co-Glycolic Acid) Electrospun Composite Nanofibers.

Yu Y, Kong L, Li L, Li N, Yan P - Nanoscale Res Lett (2015)

Bottom Line: The properties of the prepared composite nanofibrous mats were characterized by various techniques.The results showed that DOX-loaded CNTs can be readily incorporated into the nanofibers with relatively uniform distribution within the nanofibers.More importantly, the drug from the composite nanofibers can be released in a sustained and prolonged manner, and thereby, a significant antitumor efficacy in vitro is obtained.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai, Shandong, 264003, People's Republic of China.

ABSTRACT
The drug-loaded composite electrospun nanofiber has attracted more attention in biomedical field, especially in cancer therapy. In this study, a composite nanofiber was fabricated by electrospinning for cancer treatment. Firstly, the carbon nanotubes (CNTs) were selected as carriers to load the anticancer drug-doxorubicin (DOX) hydrochloride. Secondly, the DOX-loaded CNTs (DOX@CNTs) were incorporated into the poly(lactic-co-glycolic acid) (PLGA) nanofibers via electrospinning. Finally, a new drug-loaded nanofibrous scaffold (PLGA/DOX@CNTs) was formed. The properties of the prepared composite nanofibrous mats were characterized by various techniques. The release profiles of the different DOX-loaded nanofibers were measured, and the in vitro antitumor efficacy against HeLa cells was also evaluated. The results showed that DOX-loaded CNTs can be readily incorporated into the nanofibers with relatively uniform distribution within the nanofibers. More importantly, the drug from the composite nanofibers can be released in a sustained and prolonged manner, and thereby, a significant antitumor efficacy in vitro is obtained. Thus, the prepared composite nanofibrous mats are a promising alternative for cancer treatment.

No MeSH data available.


Schematic illustration for the process of fabrication of PLGA/DOX@CNTs electrospun composite nanofibers
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Fig1: Schematic illustration for the process of fabrication of PLGA/DOX@CNTs electrospun composite nanofibers

Mentions: FigureĀ 1 shows the brief fabrication process of PLGA/DOX@CNTs composite nanofibers. DOX was firstly loaded into CNTs by the physical absorption. Subsequently, the obtained DOX@CNTs was mixed with the PLGA solution to fabricate PLGA/DOX@CNTs composite nanofibers by electrospinning.Fig. 1


Antitumor Activity of Doxorubicin-Loaded Carbon Nanotubes Incorporated Poly(Lactic-Co-Glycolic Acid) Electrospun Composite Nanofibers.

Yu Y, Kong L, Li L, Li N, Yan P - Nanoscale Res Lett (2015)

Schematic illustration for the process of fabrication of PLGA/DOX@CNTs electrospun composite nanofibers
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4549354&req=5

Fig1: Schematic illustration for the process of fabrication of PLGA/DOX@CNTs electrospun composite nanofibers
Mentions: FigureĀ 1 shows the brief fabrication process of PLGA/DOX@CNTs composite nanofibers. DOX was firstly loaded into CNTs by the physical absorption. Subsequently, the obtained DOX@CNTs was mixed with the PLGA solution to fabricate PLGA/DOX@CNTs composite nanofibers by electrospinning.Fig. 1

Bottom Line: The properties of the prepared composite nanofibrous mats were characterized by various techniques.The results showed that DOX-loaded CNTs can be readily incorporated into the nanofibers with relatively uniform distribution within the nanofibers.More importantly, the drug from the composite nanofibers can be released in a sustained and prolonged manner, and thereby, a significant antitumor efficacy in vitro is obtained.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai, Shandong, 264003, People's Republic of China.

ABSTRACT
The drug-loaded composite electrospun nanofiber has attracted more attention in biomedical field, especially in cancer therapy. In this study, a composite nanofiber was fabricated by electrospinning for cancer treatment. Firstly, the carbon nanotubes (CNTs) were selected as carriers to load the anticancer drug-doxorubicin (DOX) hydrochloride. Secondly, the DOX-loaded CNTs (DOX@CNTs) were incorporated into the poly(lactic-co-glycolic acid) (PLGA) nanofibers via electrospinning. Finally, a new drug-loaded nanofibrous scaffold (PLGA/DOX@CNTs) was formed. The properties of the prepared composite nanofibrous mats were characterized by various techniques. The release profiles of the different DOX-loaded nanofibers were measured, and the in vitro antitumor efficacy against HeLa cells was also evaluated. The results showed that DOX-loaded CNTs can be readily incorporated into the nanofibers with relatively uniform distribution within the nanofibers. More importantly, the drug from the composite nanofibers can be released in a sustained and prolonged manner, and thereby, a significant antitumor efficacy in vitro is obtained. Thus, the prepared composite nanofibrous mats are a promising alternative for cancer treatment.

No MeSH data available.