Limits...
The Prognostic Value of Forkhead Box P3 Expression in Operable Breast Cancer: A Large-Scale Meta-Analysis.

Lin SC, Gan ZH, Yao Y, Min da L - PLoS ONE (2015)

Bottom Line: However, these results are controversial.The subsequent meta-analysis that was performed showed that high levels of FOXP3 are not significantly associated with DFS and OS with significant heterogeneity.For tumor cells, the pooled results revealed that FOXP3 is significantly associated with DFS (HR: 2.55, 95% CI: 1.23-5.30) but is not associated with clinicopathological parameters or OS.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Shanghai Sixth People's Hospital East Campus, Shanghai Jiao Tong University, Shanghai, People's Republic of China.

ABSTRACT

Background: Recent studies have shown that the forkhead box P3 (FOXP3) protein has a prognostic role in breast cancer. However, these results are controversial. Therefore, the aim of this meta-analysis was to clarify the prognostic role of FOXP3 expression in operable breast cancer cases.

Methods: Eligible studies describing the use of FOXP3 as a prognostic factor for operable breast cancer cases were identified. Clinicopathological features, disease-free survival (DFS), and overall survival (OS) data were collected from these studies and were analyzed using Stata software.

Results: A total of 16 articles containing data from 13,217 breast cancer patients met the inclusion criteria established for this study. The subsequent meta-analysis that was performed showed that high levels of FOXP3 are not significantly associated with DFS and OS with significant heterogeneity. An additional subgroup analysis demonstrated that intratumoral FOXP3+ regulatory T cells (Tregs) were positively correlated with adverse clinicopathological parameters, yet they did not show an association with DFS or OS. For tumor cells, the pooled results revealed that FOXP3 is significantly associated with DFS (HR: 2.55, 95% CI: 1.23-5.30) but is not associated with clinicopathological parameters or OS. We also observed a significant correlation between FOXP3 expression and survival in the estrogen receptor-positive (ER)+ subgroup (HR: 1.83, 95% CI: 1.36-2.47 for DFS, HR: 1.87, 95% CI 1.28-2.73 for OS), in the Asian region (HR: 1.98, 95% CI: 1.56-2.50 for DFS, HR: 1.93, 95% CI: 1.12-3.35 for OS) and using the median as the FOXP3-positive cut-off value (HR: 1.94, 95% CI: 1.57-2.39 for DFS, HR: 2.06; 95% CI: 1.36-3.11 for OS).

Conclusion: This meta-analysis indicates that a prognostic role for FOXP3 expression in operable breast cancer cases depends on the FOXP3-positive region, ER status, geographic region and the FOXP3-positive cut-off value.

No MeSH data available.


Related in: MedlinePlus

FOXP3 expression and OS.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4549287&req=5

pone.0136374.g004: FOXP3 expression and OS.

Mentions: No significant correlation between FOXP3 expression and patient OS was observed (HR: 1.22, 95% CI: 0.89–1.66) in a random-effects model with significant heterogeneity (P = 0.000, I2 = 85.8%) (Fig 4). Sensitivity analysis showed that the pooled estimate of the effect of FOXP3 expression on the OS of BC patients did not vary substantially with the exclusion of any one study, demonstrating that the results of this meta-analysis are stable (Fig 5). Subgroup analyses revealed that the ER status, the geographic region and the FOXP3-positive cut-off value significantly influenced the pooled HR result. We observed a significant correlation for the studies in the ER+ subgroup (HR: 1.87, 95% CI: 1.28–2.73), studies in the Asian region (HR: 1.93, 95% CI: 1.12–3.35) and studies that used the median as the cut-off value (HR: 2.06, 95% CI: 1.36–3.11). However, subgroup analysis based on other factors such as staining pattern, sample size and study design did not significantly influence the pooled HR results (Table 5).


The Prognostic Value of Forkhead Box P3 Expression in Operable Breast Cancer: A Large-Scale Meta-Analysis.

Lin SC, Gan ZH, Yao Y, Min da L - PLoS ONE (2015)

FOXP3 expression and OS.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4549287&req=5

pone.0136374.g004: FOXP3 expression and OS.
Mentions: No significant correlation between FOXP3 expression and patient OS was observed (HR: 1.22, 95% CI: 0.89–1.66) in a random-effects model with significant heterogeneity (P = 0.000, I2 = 85.8%) (Fig 4). Sensitivity analysis showed that the pooled estimate of the effect of FOXP3 expression on the OS of BC patients did not vary substantially with the exclusion of any one study, demonstrating that the results of this meta-analysis are stable (Fig 5). Subgroup analyses revealed that the ER status, the geographic region and the FOXP3-positive cut-off value significantly influenced the pooled HR result. We observed a significant correlation for the studies in the ER+ subgroup (HR: 1.87, 95% CI: 1.28–2.73), studies in the Asian region (HR: 1.93, 95% CI: 1.12–3.35) and studies that used the median as the cut-off value (HR: 2.06, 95% CI: 1.36–3.11). However, subgroup analysis based on other factors such as staining pattern, sample size and study design did not significantly influence the pooled HR results (Table 5).

Bottom Line: However, these results are controversial.The subsequent meta-analysis that was performed showed that high levels of FOXP3 are not significantly associated with DFS and OS with significant heterogeneity.For tumor cells, the pooled results revealed that FOXP3 is significantly associated with DFS (HR: 2.55, 95% CI: 1.23-5.30) but is not associated with clinicopathological parameters or OS.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Shanghai Sixth People's Hospital East Campus, Shanghai Jiao Tong University, Shanghai, People's Republic of China.

ABSTRACT

Background: Recent studies have shown that the forkhead box P3 (FOXP3) protein has a prognostic role in breast cancer. However, these results are controversial. Therefore, the aim of this meta-analysis was to clarify the prognostic role of FOXP3 expression in operable breast cancer cases.

Methods: Eligible studies describing the use of FOXP3 as a prognostic factor for operable breast cancer cases were identified. Clinicopathological features, disease-free survival (DFS), and overall survival (OS) data were collected from these studies and were analyzed using Stata software.

Results: A total of 16 articles containing data from 13,217 breast cancer patients met the inclusion criteria established for this study. The subsequent meta-analysis that was performed showed that high levels of FOXP3 are not significantly associated with DFS and OS with significant heterogeneity. An additional subgroup analysis demonstrated that intratumoral FOXP3+ regulatory T cells (Tregs) were positively correlated with adverse clinicopathological parameters, yet they did not show an association with DFS or OS. For tumor cells, the pooled results revealed that FOXP3 is significantly associated with DFS (HR: 2.55, 95% CI: 1.23-5.30) but is not associated with clinicopathological parameters or OS. We also observed a significant correlation between FOXP3 expression and survival in the estrogen receptor-positive (ER)+ subgroup (HR: 1.83, 95% CI: 1.36-2.47 for DFS, HR: 1.87, 95% CI 1.28-2.73 for OS), in the Asian region (HR: 1.98, 95% CI: 1.56-2.50 for DFS, HR: 1.93, 95% CI: 1.12-3.35 for OS) and using the median as the FOXP3-positive cut-off value (HR: 1.94, 95% CI: 1.57-2.39 for DFS, HR: 2.06; 95% CI: 1.36-3.11 for OS).

Conclusion: This meta-analysis indicates that a prognostic role for FOXP3 expression in operable breast cancer cases depends on the FOXP3-positive region, ER status, geographic region and the FOXP3-positive cut-off value.

No MeSH data available.


Related in: MedlinePlus