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Prostate Tumor Overexpressed 1 (PTOV1) Is a Novel Prognostic Marker for Nasopharyngeal Carcinoma Progression and Poor Survival Outcomes.

Yang Q, Lin H, Wu S, Lei F, Zhu X, Song L, Hong M, Guo L - PLoS ONE (2015)

Bottom Line: Patients with a higher PTOV1 expression had shorter overall survival compared with those with a lower PTOV1 expression level, especially in lower N stage patients.Our data demonstrated that PTOV1 overexpression is associated with poor survival outcomes of NPC patients, especially in N0-1 patients.Hence, PTOV1 may help to detect early lymph node metastasis of NPC patients and serve as an independent prognostic biomarker for human NPC.

View Article: PubMed Central - PubMed

Affiliation: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, P.R. China; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, 510060, P.R. China.

ABSTRACT

Background: Prostate tumor overexpressed 1 (PTOV1) has been reported to contribute to increased cancer proliferation. However, the clinical significance of PTOV1 in the development and progression of nasopharyngeal carcinoma (NPC) is unclear. Our study aimed to investigate the expression pattern of PTOV1 in NPC and its correlation with clinicopathological features of patients.

Methods: Western blotting and real-time PCR were conducted to examine PTOV1 expression levels in NPC cell lines and biopsy tissues compared with normal controls. Immunohistochemistry (IHC) was performed to analyze PTOV1 protein expression in paraffin-embedded tissues from 123 patients. Statistical analyses were applied to evaluate the clinical significance of PTOV1 expression.

Results: PTOV1 mRNA and protein levels were upregulated in NPC cell lines and clinical samples. IHC analyses showed that PTOV1 was highly expressed in 68 (55.3%) of 123 NPC specimens. Statistical analysis revealed that PTOV1 expression was significantly correlated with clinical stage (P < 0.001), T classification (P = 0.042) and N classification (P = 0.001). Patients with a higher PTOV1 expression had shorter overall survival compared with those with a lower PTOV1 expression level, especially in lower N stage patients. Multivariate analyses suggested that PTOV1 expression was an independent prognostic marker for survival in NPC patients.

Conclusions: Our data demonstrated that PTOV1 overexpression is associated with poor survival outcomes of NPC patients, especially in N0-1 patients. Hence, PTOV1 may help to detect early lymph node metastasis of NPC patients and serve as an independent prognostic biomarker for human NPC.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier curves with univariate analysis (log-rank).(A and B) OS (A) and PFS (B) rates for cases with high PTOV1 expression versus cases with low PTOV1 expression levels in all patients. (C and D) OS (C) and PFS (D) rates for late clinical stage cases (stage III/IV) with high PTOV1 expression versus cases with low PTOV1 expression levels. (E) OS rate for cases with high PTOV1 expression versus cases with low PTOV1 expression in patients with N0-N1 grade tumors. (F) OS rate for cases with high PTOV1 expression versus cases with low PTOV1 expression in patients with N2-N3 grade tumors.
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pone.0136448.g004: Kaplan-Meier curves with univariate analysis (log-rank).(A and B) OS (A) and PFS (B) rates for cases with high PTOV1 expression versus cases with low PTOV1 expression levels in all patients. (C and D) OS (C) and PFS (D) rates for late clinical stage cases (stage III/IV) with high PTOV1 expression versus cases with low PTOV1 expression levels. (E) OS rate for cases with high PTOV1 expression versus cases with low PTOV1 expression in patients with N0-N1 grade tumors. (F) OS rate for cases with high PTOV1 expression versus cases with low PTOV1 expression in patients with N2-N3 grade tumors.

Mentions: Patient survival analysis showed an explicit negative correlation between the level of PTOV1 expression and both the overall survival (OS) and progression-free survival (PFS) of NPC patients (both P = 0.001, Fig 4A and 4B). The 5-year OS and PFS rates of the PTOV1 low expression group were 87.8% and 72.7%, respectively, whereas those of the PTOV1 high expression group were 59.6% and 29.4%, respectively.


Prostate Tumor Overexpressed 1 (PTOV1) Is a Novel Prognostic Marker for Nasopharyngeal Carcinoma Progression and Poor Survival Outcomes.

Yang Q, Lin H, Wu S, Lei F, Zhu X, Song L, Hong M, Guo L - PLoS ONE (2015)

Kaplan-Meier curves with univariate analysis (log-rank).(A and B) OS (A) and PFS (B) rates for cases with high PTOV1 expression versus cases with low PTOV1 expression levels in all patients. (C and D) OS (C) and PFS (D) rates for late clinical stage cases (stage III/IV) with high PTOV1 expression versus cases with low PTOV1 expression levels. (E) OS rate for cases with high PTOV1 expression versus cases with low PTOV1 expression in patients with N0-N1 grade tumors. (F) OS rate for cases with high PTOV1 expression versus cases with low PTOV1 expression in patients with N2-N3 grade tumors.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4549246&req=5

pone.0136448.g004: Kaplan-Meier curves with univariate analysis (log-rank).(A and B) OS (A) and PFS (B) rates for cases with high PTOV1 expression versus cases with low PTOV1 expression levels in all patients. (C and D) OS (C) and PFS (D) rates for late clinical stage cases (stage III/IV) with high PTOV1 expression versus cases with low PTOV1 expression levels. (E) OS rate for cases with high PTOV1 expression versus cases with low PTOV1 expression in patients with N0-N1 grade tumors. (F) OS rate for cases with high PTOV1 expression versus cases with low PTOV1 expression in patients with N2-N3 grade tumors.
Mentions: Patient survival analysis showed an explicit negative correlation between the level of PTOV1 expression and both the overall survival (OS) and progression-free survival (PFS) of NPC patients (both P = 0.001, Fig 4A and 4B). The 5-year OS and PFS rates of the PTOV1 low expression group were 87.8% and 72.7%, respectively, whereas those of the PTOV1 high expression group were 59.6% and 29.4%, respectively.

Bottom Line: Patients with a higher PTOV1 expression had shorter overall survival compared with those with a lower PTOV1 expression level, especially in lower N stage patients.Our data demonstrated that PTOV1 overexpression is associated with poor survival outcomes of NPC patients, especially in N0-1 patients.Hence, PTOV1 may help to detect early lymph node metastasis of NPC patients and serve as an independent prognostic biomarker for human NPC.

View Article: PubMed Central - PubMed

Affiliation: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, P.R. China; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, 510060, P.R. China.

ABSTRACT

Background: Prostate tumor overexpressed 1 (PTOV1) has been reported to contribute to increased cancer proliferation. However, the clinical significance of PTOV1 in the development and progression of nasopharyngeal carcinoma (NPC) is unclear. Our study aimed to investigate the expression pattern of PTOV1 in NPC and its correlation with clinicopathological features of patients.

Methods: Western blotting and real-time PCR were conducted to examine PTOV1 expression levels in NPC cell lines and biopsy tissues compared with normal controls. Immunohistochemistry (IHC) was performed to analyze PTOV1 protein expression in paraffin-embedded tissues from 123 patients. Statistical analyses were applied to evaluate the clinical significance of PTOV1 expression.

Results: PTOV1 mRNA and protein levels were upregulated in NPC cell lines and clinical samples. IHC analyses showed that PTOV1 was highly expressed in 68 (55.3%) of 123 NPC specimens. Statistical analysis revealed that PTOV1 expression was significantly correlated with clinical stage (P < 0.001), T classification (P = 0.042) and N classification (P = 0.001). Patients with a higher PTOV1 expression had shorter overall survival compared with those with a lower PTOV1 expression level, especially in lower N stage patients. Multivariate analyses suggested that PTOV1 expression was an independent prognostic marker for survival in NPC patients.

Conclusions: Our data demonstrated that PTOV1 overexpression is associated with poor survival outcomes of NPC patients, especially in N0-1 patients. Hence, PTOV1 may help to detect early lymph node metastasis of NPC patients and serve as an independent prognostic biomarker for human NPC.

No MeSH data available.


Related in: MedlinePlus