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Nanofibrous scaffolds in biomedical applications.

Gupta KC, Haider A, Choi YR, Kang IK - Biomater Res (2014)

Bottom Line: Nanofibrous scaffolds are artificial extracellular matrices which provide natural environment for tissue formation.Attempts have also been made to highlights the advantages and disadvantages of nanofirbous scaffolds fabricated for biomedical applications using technique of electrospinning.The role of various factors controlling drug distribution in electrospun nanofibrous scaffolds is also discussed to increase the therapeutic efficiency of nanofibrous scaffolds in wound healing and drug delivery applications.

View Article: PubMed Central - PubMed

Affiliation: Department of Polymer Science and Engineering, Kyungpook National University, Daegu, 702-701 South Korea ; Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247 667 India.

ABSTRACT
Nanofibrous scaffolds are artificial extracellular matrices which provide natural environment for tissue formation. In comparison to other forms of scaffolds, the nanofibrous scaffolds promote cell adhesion, proliferation and differentiation more efficiently due to having high surface to volume ratio. Although scaffolds for tissue engineering have been fabricated by various techniques but electrospun nanofibrous scaffolds have shown great potential in the fields of tissue engineering and regeneration. This review highlights the applications and importance of electrospun nanofibrous scaffolds in various fields of biomedical applications ranging from drug delivery to wound healing. Attempts have also been made to highlights the advantages and disadvantages of nanofirbous scaffolds fabricated for biomedical applications using technique of electrospinning. The role of various factors controlling drug distribution in electrospun nanofibrous scaffolds is also discussed to increase the therapeutic efficiency of nanofibrous scaffolds in wound healing and drug delivery applications.

No MeSH data available.


Related in: MedlinePlus

AFM phase images of nanofibrous scaffold surface; (a) PHBV and (b) PHBV–Col (Adapted from reference[128]).
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Fig4: AFM phase images of nanofibrous scaffold surface; (a) PHBV and (b) PHBV–Col (Adapted from reference[128]).

Mentions: On acceleration of solution jet toward grounded collector, the solvent evaporated and a charged polymer nanofiber was deposited on grounded collector as nanofiber web. The electrospinning of nanofibrous scaffolds was done at different weight ratios of PHBV and collagen (7:3, 5:5, and 3:7), which produced nanofibrous scaffolds with smooth morphology. The addition of PHBV in collagen has produced nanofibrous scaffolds with heterogeneous surfaces, which enhanced the application of electrospun nanofibers in tissue engineering (Figure 4). The synthetic polymers after blending with natural polymers have been used successfully in tissue engineering. The electrospun nanofibrous scaffolds obtained from the gelatin blends with PCL and PLA have shown better proliferation and expression for osteoblastic cells in comparison to pure PCL and PLA[129, 130]. The blending of collagen with PCL has proved to be useful in improving the mechanical properties of electrospun fibers as percent elongation has increased significantly on addition of collagen in PCL without altering the tensile strength of original PCL[131].Figure 4


Nanofibrous scaffolds in biomedical applications.

Gupta KC, Haider A, Choi YR, Kang IK - Biomater Res (2014)

AFM phase images of nanofibrous scaffold surface; (a) PHBV and (b) PHBV–Col (Adapted from reference[128]).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4549138&req=5

Fig4: AFM phase images of nanofibrous scaffold surface; (a) PHBV and (b) PHBV–Col (Adapted from reference[128]).
Mentions: On acceleration of solution jet toward grounded collector, the solvent evaporated and a charged polymer nanofiber was deposited on grounded collector as nanofiber web. The electrospinning of nanofibrous scaffolds was done at different weight ratios of PHBV and collagen (7:3, 5:5, and 3:7), which produced nanofibrous scaffolds with smooth morphology. The addition of PHBV in collagen has produced nanofibrous scaffolds with heterogeneous surfaces, which enhanced the application of electrospun nanofibers in tissue engineering (Figure 4). The synthetic polymers after blending with natural polymers have been used successfully in tissue engineering. The electrospun nanofibrous scaffolds obtained from the gelatin blends with PCL and PLA have shown better proliferation and expression for osteoblastic cells in comparison to pure PCL and PLA[129, 130]. The blending of collagen with PCL has proved to be useful in improving the mechanical properties of electrospun fibers as percent elongation has increased significantly on addition of collagen in PCL without altering the tensile strength of original PCL[131].Figure 4

Bottom Line: Nanofibrous scaffolds are artificial extracellular matrices which provide natural environment for tissue formation.Attempts have also been made to highlights the advantages and disadvantages of nanofirbous scaffolds fabricated for biomedical applications using technique of electrospinning.The role of various factors controlling drug distribution in electrospun nanofibrous scaffolds is also discussed to increase the therapeutic efficiency of nanofibrous scaffolds in wound healing and drug delivery applications.

View Article: PubMed Central - PubMed

Affiliation: Department of Polymer Science and Engineering, Kyungpook National University, Daegu, 702-701 South Korea ; Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247 667 India.

ABSTRACT
Nanofibrous scaffolds are artificial extracellular matrices which provide natural environment for tissue formation. In comparison to other forms of scaffolds, the nanofibrous scaffolds promote cell adhesion, proliferation and differentiation more efficiently due to having high surface to volume ratio. Although scaffolds for tissue engineering have been fabricated by various techniques but electrospun nanofibrous scaffolds have shown great potential in the fields of tissue engineering and regeneration. This review highlights the applications and importance of electrospun nanofibrous scaffolds in various fields of biomedical applications ranging from drug delivery to wound healing. Attempts have also been made to highlights the advantages and disadvantages of nanofirbous scaffolds fabricated for biomedical applications using technique of electrospinning. The role of various factors controlling drug distribution in electrospun nanofibrous scaffolds is also discussed to increase the therapeutic efficiency of nanofibrous scaffolds in wound healing and drug delivery applications.

No MeSH data available.


Related in: MedlinePlus