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Nanofibrous scaffolds in biomedical applications.

Gupta KC, Haider A, Choi YR, Kang IK - Biomater Res (2014)

Bottom Line: Nanofibrous scaffolds are artificial extracellular matrices which provide natural environment for tissue formation.Attempts have also been made to highlights the advantages and disadvantages of nanofirbous scaffolds fabricated for biomedical applications using technique of electrospinning.The role of various factors controlling drug distribution in electrospun nanofibrous scaffolds is also discussed to increase the therapeutic efficiency of nanofibrous scaffolds in wound healing and drug delivery applications.

View Article: PubMed Central - PubMed

Affiliation: Department of Polymer Science and Engineering, Kyungpook National University, Daegu, 702-701 South Korea ; Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247 667 India.

ABSTRACT
Nanofibrous scaffolds are artificial extracellular matrices which provide natural environment for tissue formation. In comparison to other forms of scaffolds, the nanofibrous scaffolds promote cell adhesion, proliferation and differentiation more efficiently due to having high surface to volume ratio. Although scaffolds for tissue engineering have been fabricated by various techniques but electrospun nanofibrous scaffolds have shown great potential in the fields of tissue engineering and regeneration. This review highlights the applications and importance of electrospun nanofibrous scaffolds in various fields of biomedical applications ranging from drug delivery to wound healing. Attempts have also been made to highlights the advantages and disadvantages of nanofirbous scaffolds fabricated for biomedical applications using technique of electrospinning. The role of various factors controlling drug distribution in electrospun nanofibrous scaffolds is also discussed to increase the therapeutic efficiency of nanofibrous scaffolds in wound healing and drug delivery applications.

No MeSH data available.


Related in: MedlinePlus

SEM micrographs of electrospun nanofibrous scaffolds using a PHBV/gelatin solution at TFE 6 wt%; (a) 30/70, (b) 50/50, and (c) 70/30 (adapted from reference[127]).
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Fig2: SEM micrographs of electrospun nanofibrous scaffolds using a PHBV/gelatin solution at TFE 6 wt%; (a) 30/70, (b) 50/50, and (c) 70/30 (adapted from reference[127]).

Mentions: Amongst the various types of scaffolds, the electrospun nanofibrous scaffolds have attracted great attention in tissue engineering due to high surface to volume ratio and due to various possibilities to control their properties and applications[120–123]. The electrospun nanofibrous scaffolds are cost effective and able to act as extra cellular material to provide cell adhesion, proliferation and differentiation. The electrospun nanofibers for bone tissue culturing and regeneration utilize a range of biopolymers with synthetic origin, which include poly(α-hydroxyl acid) and poly(hydroxyalkanoate), such as poly(hydroxybutyrate) (PHB). The natural polymers such as collagen, gelatin, silk, and chitosan are also considered useful for bone tissue regeneration. The PCL has long been studied as a degradable nanofiber matrix for bone regeneration[124] and Rat bone marrow has demonstrated the secretion of type I collagen and calcium mineralization within 4 weeks of culturing. The PLA nanofibers have also shown good response toward MC3T3-E1 bone cells[125]. The PHB and poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) electrospun nanofibers have shown enhanced osteoblastic activity equivalent to flat membrane scaffolds[126]. The gelatin has been used as a tissue engineering material by blending with PHBV, due to its low cost and hydrophilicity. The PHBV/gelatin nanofibrous scaffolds were obtained by co-electrospinning a transparent polymer solution of gelatin and PHBV in 2,2,2-trifluoroethanol (TFE) at a volume ratio of 50/50[127]. The effect of gelatin on the morphology of nanofibrous scaffolds was examined using different ratios of PHBV and gelatin (Figure 2).A smooth and uniform electrospun nanofibrous scaffolds were obtained by varying the weight percent from 2-8% in the solvent (Figure 3).Figure 2


Nanofibrous scaffolds in biomedical applications.

Gupta KC, Haider A, Choi YR, Kang IK - Biomater Res (2014)

SEM micrographs of electrospun nanofibrous scaffolds using a PHBV/gelatin solution at TFE 6 wt%; (a) 30/70, (b) 50/50, and (c) 70/30 (adapted from reference[127]).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4549138&req=5

Fig2: SEM micrographs of electrospun nanofibrous scaffolds using a PHBV/gelatin solution at TFE 6 wt%; (a) 30/70, (b) 50/50, and (c) 70/30 (adapted from reference[127]).
Mentions: Amongst the various types of scaffolds, the electrospun nanofibrous scaffolds have attracted great attention in tissue engineering due to high surface to volume ratio and due to various possibilities to control their properties and applications[120–123]. The electrospun nanofibrous scaffolds are cost effective and able to act as extra cellular material to provide cell adhesion, proliferation and differentiation. The electrospun nanofibers for bone tissue culturing and regeneration utilize a range of biopolymers with synthetic origin, which include poly(α-hydroxyl acid) and poly(hydroxyalkanoate), such as poly(hydroxybutyrate) (PHB). The natural polymers such as collagen, gelatin, silk, and chitosan are also considered useful for bone tissue regeneration. The PCL has long been studied as a degradable nanofiber matrix for bone regeneration[124] and Rat bone marrow has demonstrated the secretion of type I collagen and calcium mineralization within 4 weeks of culturing. The PLA nanofibers have also shown good response toward MC3T3-E1 bone cells[125]. The PHB and poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) electrospun nanofibers have shown enhanced osteoblastic activity equivalent to flat membrane scaffolds[126]. The gelatin has been used as a tissue engineering material by blending with PHBV, due to its low cost and hydrophilicity. The PHBV/gelatin nanofibrous scaffolds were obtained by co-electrospinning a transparent polymer solution of gelatin and PHBV in 2,2,2-trifluoroethanol (TFE) at a volume ratio of 50/50[127]. The effect of gelatin on the morphology of nanofibrous scaffolds was examined using different ratios of PHBV and gelatin (Figure 2).A smooth and uniform electrospun nanofibrous scaffolds were obtained by varying the weight percent from 2-8% in the solvent (Figure 3).Figure 2

Bottom Line: Nanofibrous scaffolds are artificial extracellular matrices which provide natural environment for tissue formation.Attempts have also been made to highlights the advantages and disadvantages of nanofirbous scaffolds fabricated for biomedical applications using technique of electrospinning.The role of various factors controlling drug distribution in electrospun nanofibrous scaffolds is also discussed to increase the therapeutic efficiency of nanofibrous scaffolds in wound healing and drug delivery applications.

View Article: PubMed Central - PubMed

Affiliation: Department of Polymer Science and Engineering, Kyungpook National University, Daegu, 702-701 South Korea ; Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247 667 India.

ABSTRACT
Nanofibrous scaffolds are artificial extracellular matrices which provide natural environment for tissue formation. In comparison to other forms of scaffolds, the nanofibrous scaffolds promote cell adhesion, proliferation and differentiation more efficiently due to having high surface to volume ratio. Although scaffolds for tissue engineering have been fabricated by various techniques but electrospun nanofibrous scaffolds have shown great potential in the fields of tissue engineering and regeneration. This review highlights the applications and importance of electrospun nanofibrous scaffolds in various fields of biomedical applications ranging from drug delivery to wound healing. Attempts have also been made to highlights the advantages and disadvantages of nanofirbous scaffolds fabricated for biomedical applications using technique of electrospinning. The role of various factors controlling drug distribution in electrospun nanofibrous scaffolds is also discussed to increase the therapeutic efficiency of nanofibrous scaffolds in wound healing and drug delivery applications.

No MeSH data available.


Related in: MedlinePlus