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Activation of cerebellar lobules VI-VII during motor imagery but not during motor activation in unilateral cerebellar hypoplasia.

Habas C, Manto M - Cerebellum Ataxias (2014)

Bottom Line: We compared brain activation during overt and covert finger movements, and haptic discrimination.Moreover, the resting-state functional connectivity did not show compensatory functional coherence between the right cerebellum and cerebral areas connected with the hypoplastic cerebellum.Our case illustrates for the first time that cerebellar compensatory recruitment is an active, specific process related to task complexity and under the control of executive networks.

View Article: PubMed Central - PubMed

Affiliation: Service de NeuroImagerie, Centre Hospitalier National d'Ophtalmologie des XV-XX, 28, rue de Charenton, Paris, 75012 France.

ABSTRACT
We report the case of a 25 year-old patient who underwent morphological and functional brain magnetic resonance imaging (fMRI) to investigate a left neocerebellar hypoplasia discovered incidentally. We compared brain activation during overt and covert finger movements, and haptic discrimination. The contralateral cerebellar hemisphere compensated for mental imagery of hand movements and haptic discrimination, but not for motor execution. Moreover, the resting-state functional connectivity did not show compensatory functional coherence between the right cerebellum and cerebral areas connected with the hypoplastic cerebellum. Our case illustrates for the first time that cerebellar compensatory recruitment is an active, specific process related to task complexity and under the control of executive networks.

No MeSH data available.


Related in: MedlinePlus

Statistical parametric maps of the main neural activity of the patient while performing thumb-to-fingers opposition with the left hand (A) and with the right hand (B), and during mental imagery of the same left (C) and right (D) movements. A1-B1-C1-D1. Axial slices. A2-B2-C2-D2. Coronal slices. A3-B3-C3-D3. No significant cerebellar activation is detected during left movements. Sagittal slices. Abbreviations: ACC anterior cingulate cortex; M1/S1 sensorimotor cortex ; PMC premotor cortex; (pre-) SMA (pre-) supplementray motor cortex; SPL superior parietal lobule. Roman numbers indicate the cerebellar lobules. R right side.
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Fig4: Statistical parametric maps of the main neural activity of the patient while performing thumb-to-fingers opposition with the left hand (A) and with the right hand (B), and during mental imagery of the same left (C) and right (D) movements. A1-B1-C1-D1. Axial slices. A2-B2-C2-D2. Coronal slices. A3-B3-C3-D3. No significant cerebellar activation is detected during left movements. Sagittal slices. Abbreviations: ACC anterior cingulate cortex; M1/S1 sensorimotor cortex ; PMC premotor cortex; (pre-) SMA (pre-) supplementray motor cortex; SPL superior parietal lobule. Roman numbers indicate the cerebellar lobules. R right side.

Mentions: In all tasks, we failed to detect any left cerebellar activation (Table 1). For the right hand, we observed an activation of right cerebellar lobules VI and VIII during motor execution (the superior and inferior cerebellar motor homunculi), as anticipated (Figures 4A-4B; Table 1). However, left finger movements did not activate cerebellar lobules VI and VIII. Imagery of both right and left finger movements was associated with a clear activation of right lobules VI-VII (Figures 4C-AD). Moreover, unilateral haptic discrimination with left and right hands also recruited the right neocerebellum (lobules VI-VII-VIII) (Figure 5).Table 1


Activation of cerebellar lobules VI-VII during motor imagery but not during motor activation in unilateral cerebellar hypoplasia.

Habas C, Manto M - Cerebellum Ataxias (2014)

Statistical parametric maps of the main neural activity of the patient while performing thumb-to-fingers opposition with the left hand (A) and with the right hand (B), and during mental imagery of the same left (C) and right (D) movements. A1-B1-C1-D1. Axial slices. A2-B2-C2-D2. Coronal slices. A3-B3-C3-D3. No significant cerebellar activation is detected during left movements. Sagittal slices. Abbreviations: ACC anterior cingulate cortex; M1/S1 sensorimotor cortex ; PMC premotor cortex; (pre-) SMA (pre-) supplementray motor cortex; SPL superior parietal lobule. Roman numbers indicate the cerebellar lobules. R right side.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4549134&req=5

Fig4: Statistical parametric maps of the main neural activity of the patient while performing thumb-to-fingers opposition with the left hand (A) and with the right hand (B), and during mental imagery of the same left (C) and right (D) movements. A1-B1-C1-D1. Axial slices. A2-B2-C2-D2. Coronal slices. A3-B3-C3-D3. No significant cerebellar activation is detected during left movements. Sagittal slices. Abbreviations: ACC anterior cingulate cortex; M1/S1 sensorimotor cortex ; PMC premotor cortex; (pre-) SMA (pre-) supplementray motor cortex; SPL superior parietal lobule. Roman numbers indicate the cerebellar lobules. R right side.
Mentions: In all tasks, we failed to detect any left cerebellar activation (Table 1). For the right hand, we observed an activation of right cerebellar lobules VI and VIII during motor execution (the superior and inferior cerebellar motor homunculi), as anticipated (Figures 4A-4B; Table 1). However, left finger movements did not activate cerebellar lobules VI and VIII. Imagery of both right and left finger movements was associated with a clear activation of right lobules VI-VII (Figures 4C-AD). Moreover, unilateral haptic discrimination with left and right hands also recruited the right neocerebellum (lobules VI-VII-VIII) (Figure 5).Table 1

Bottom Line: We compared brain activation during overt and covert finger movements, and haptic discrimination.Moreover, the resting-state functional connectivity did not show compensatory functional coherence between the right cerebellum and cerebral areas connected with the hypoplastic cerebellum.Our case illustrates for the first time that cerebellar compensatory recruitment is an active, specific process related to task complexity and under the control of executive networks.

View Article: PubMed Central - PubMed

Affiliation: Service de NeuroImagerie, Centre Hospitalier National d'Ophtalmologie des XV-XX, 28, rue de Charenton, Paris, 75012 France.

ABSTRACT
We report the case of a 25 year-old patient who underwent morphological and functional brain magnetic resonance imaging (fMRI) to investigate a left neocerebellar hypoplasia discovered incidentally. We compared brain activation during overt and covert finger movements, and haptic discrimination. The contralateral cerebellar hemisphere compensated for mental imagery of hand movements and haptic discrimination, but not for motor execution. Moreover, the resting-state functional connectivity did not show compensatory functional coherence between the right cerebellum and cerebral areas connected with the hypoplastic cerebellum. Our case illustrates for the first time that cerebellar compensatory recruitment is an active, specific process related to task complexity and under the control of executive networks.

No MeSH data available.


Related in: MedlinePlus