Limits...
Activation of cerebellar lobules VI-VII during motor imagery but not during motor activation in unilateral cerebellar hypoplasia.

Habas C, Manto M - Cerebellum Ataxias (2014)

Bottom Line: We compared brain activation during overt and covert finger movements, and haptic discrimination.Moreover, the resting-state functional connectivity did not show compensatory functional coherence between the right cerebellum and cerebral areas connected with the hypoplastic cerebellum.Our case illustrates for the first time that cerebellar compensatory recruitment is an active, specific process related to task complexity and under the control of executive networks.

View Article: PubMed Central - PubMed

Affiliation: Service de NeuroImagerie, Centre Hospitalier National d'Ophtalmologie des XV-XX, 28, rue de Charenton, Paris, 75012 France.

ABSTRACT
We report the case of a 25 year-old patient who underwent morphological and functional brain magnetic resonance imaging (fMRI) to investigate a left neocerebellar hypoplasia discovered incidentally. We compared brain activation during overt and covert finger movements, and haptic discrimination. The contralateral cerebellar hemisphere compensated for mental imagery of hand movements and haptic discrimination, but not for motor execution. Moreover, the resting-state functional connectivity did not show compensatory functional coherence between the right cerebellum and cerebral areas connected with the hypoplastic cerebellum. Our case illustrates for the first time that cerebellar compensatory recruitment is an active, specific process related to task complexity and under the control of executive networks.

No MeSH data available.


Related in: MedlinePlus

FLAIR-CUBE image of the encephalon showing left neocerebellar hypoplasia. A. Sagittal slices. B. Coronal slices. C. Axial slices passing through the posterior fossa. R. Right side.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4549134&req=5

Fig1: FLAIR-CUBE image of the encephalon showing left neocerebellar hypoplasia. A. Sagittal slices. B. Coronal slices. C. Axial slices passing through the posterior fossa. R. Right side.

Mentions: A left unilateral cerebellar hypoplasia affecting VII/VIII/IX/X lobules and the dentate nucleus was confirmed (Figure 1). We also found a lesser volume of the right red nucleus compared to the left one (Figure 2). On the left side, inferior, middle and superior cerebellar arteries were present but the two former were spindly (not illustrated).Figure 1


Activation of cerebellar lobules VI-VII during motor imagery but not during motor activation in unilateral cerebellar hypoplasia.

Habas C, Manto M - Cerebellum Ataxias (2014)

FLAIR-CUBE image of the encephalon showing left neocerebellar hypoplasia. A. Sagittal slices. B. Coronal slices. C. Axial slices passing through the posterior fossa. R. Right side.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4549134&req=5

Fig1: FLAIR-CUBE image of the encephalon showing left neocerebellar hypoplasia. A. Sagittal slices. B. Coronal slices. C. Axial slices passing through the posterior fossa. R. Right side.
Mentions: A left unilateral cerebellar hypoplasia affecting VII/VIII/IX/X lobules and the dentate nucleus was confirmed (Figure 1). We also found a lesser volume of the right red nucleus compared to the left one (Figure 2). On the left side, inferior, middle and superior cerebellar arteries were present but the two former were spindly (not illustrated).Figure 1

Bottom Line: We compared brain activation during overt and covert finger movements, and haptic discrimination.Moreover, the resting-state functional connectivity did not show compensatory functional coherence between the right cerebellum and cerebral areas connected with the hypoplastic cerebellum.Our case illustrates for the first time that cerebellar compensatory recruitment is an active, specific process related to task complexity and under the control of executive networks.

View Article: PubMed Central - PubMed

Affiliation: Service de NeuroImagerie, Centre Hospitalier National d'Ophtalmologie des XV-XX, 28, rue de Charenton, Paris, 75012 France.

ABSTRACT
We report the case of a 25 year-old patient who underwent morphological and functional brain magnetic resonance imaging (fMRI) to investigate a left neocerebellar hypoplasia discovered incidentally. We compared brain activation during overt and covert finger movements, and haptic discrimination. The contralateral cerebellar hemisphere compensated for mental imagery of hand movements and haptic discrimination, but not for motor execution. Moreover, the resting-state functional connectivity did not show compensatory functional coherence between the right cerebellum and cerebral areas connected with the hypoplastic cerebellum. Our case illustrates for the first time that cerebellar compensatory recruitment is an active, specific process related to task complexity and under the control of executive networks.

No MeSH data available.


Related in: MedlinePlus