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Adult stem cells and tissue engineering strategies for salivary gland regeneration: a review.

Yoo C, Vines JB, Alexander G, Murdock K, Hwang P, Jun HW - Biomater Res (2014)

Bottom Line: Hyposalivation negatively affects speaking, mastication, and swallowing in afflicted patients, greatly reducing their quality of life.However, many of these treatments do not address the underlying issues and others are pervaded by numerous side effects.Tissue engineering is defined as the application of life sciences and materials engineering toward the development of tissue substitutes that are capable of mimicking the structure and function of their natural analogues within the body.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering, University of Alabama at Birmingham, Shelby Building 806, 1825 University Boulevard, Birmingham, AL 35294 USA ; Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Gyeonggi-do, Bundang-gu, Seongnam-si, 463-712 South Korea.

ABSTRACT
Saliva is an important compound produced by the salivary glands and performs numerous functions. Hyposalivation (dry mouth syndrome) is a deleterious condition often resulting from radiotherapy for patients with head and neck cancer, Sjogren's Syndrome, or as a side effect of certain medications. Hyposalivation negatively affects speaking, mastication, and swallowing in afflicted patients, greatly reducing their quality of life. Current treatments for this pathology include modifying lifestyle, synthetic saliva supplementation, and the utilization of salivary gland stimulants and sialagogues. However, many of these treatments do not address the underlying issues and others are pervaded by numerous side effects. In order to address the shortcomings related to current treatment modalities, many groups have diverted their attention to utilizing tissue engineering and regenerative medicine approaches. Tissue engineering is defined as the application of life sciences and materials engineering toward the development of tissue substitutes that are capable of mimicking the structure and function of their natural analogues within the body. The general underlying strategy behind the development of tissue engineered organ substitutes is the utilization of a combination of cells, biomaterials, and biochemical cues intended to recreate the natural organ environment. The purpose of this review is to highlight current bioengineering approaches for salivary gland tissue engineering and the adult stem cell sources used for this purpose. Additionally, future considerations in regard to salivary gland tissue engineering strategies are discussed.

No MeSH data available.


Related in: MedlinePlus

Schematic representation of a generic salivary gland showing component cell types and theorized stem and progenitor cell locations. Reproduced with permission from: [18].
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Fig1: Schematic representation of a generic salivary gland showing component cell types and theorized stem and progenitor cell locations. Reproduced with permission from: [18].

Mentions: The salivary glands of most mammals are made up of three main cell types: serous producing acinar cells, mucous producing acinar cells, and myoepithelial cells [16]. Serous producing acinar cells have a pyramidal morphology and are joined together to form spheroidal shapes while mucous producing acinar cells are cuboidal in shape and group together to form tubules. Myoepithelial cells are located near the ductal openings and serve to contract the ducts in order to squeeze out salivary secretions (FigureĀ 1) [18].Figure 1


Adult stem cells and tissue engineering strategies for salivary gland regeneration: a review.

Yoo C, Vines JB, Alexander G, Murdock K, Hwang P, Jun HW - Biomater Res (2014)

Schematic representation of a generic salivary gland showing component cell types and theorized stem and progenitor cell locations. Reproduced with permission from: [18].
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4549133&req=5

Fig1: Schematic representation of a generic salivary gland showing component cell types and theorized stem and progenitor cell locations. Reproduced with permission from: [18].
Mentions: The salivary glands of most mammals are made up of three main cell types: serous producing acinar cells, mucous producing acinar cells, and myoepithelial cells [16]. Serous producing acinar cells have a pyramidal morphology and are joined together to form spheroidal shapes while mucous producing acinar cells are cuboidal in shape and group together to form tubules. Myoepithelial cells are located near the ductal openings and serve to contract the ducts in order to squeeze out salivary secretions (FigureĀ 1) [18].Figure 1

Bottom Line: Hyposalivation negatively affects speaking, mastication, and swallowing in afflicted patients, greatly reducing their quality of life.However, many of these treatments do not address the underlying issues and others are pervaded by numerous side effects.Tissue engineering is defined as the application of life sciences and materials engineering toward the development of tissue substitutes that are capable of mimicking the structure and function of their natural analogues within the body.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering, University of Alabama at Birmingham, Shelby Building 806, 1825 University Boulevard, Birmingham, AL 35294 USA ; Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Gyeonggi-do, Bundang-gu, Seongnam-si, 463-712 South Korea.

ABSTRACT
Saliva is an important compound produced by the salivary glands and performs numerous functions. Hyposalivation (dry mouth syndrome) is a deleterious condition often resulting from radiotherapy for patients with head and neck cancer, Sjogren's Syndrome, or as a side effect of certain medications. Hyposalivation negatively affects speaking, mastication, and swallowing in afflicted patients, greatly reducing their quality of life. Current treatments for this pathology include modifying lifestyle, synthetic saliva supplementation, and the utilization of salivary gland stimulants and sialagogues. However, many of these treatments do not address the underlying issues and others are pervaded by numerous side effects. In order to address the shortcomings related to current treatment modalities, many groups have diverted their attention to utilizing tissue engineering and regenerative medicine approaches. Tissue engineering is defined as the application of life sciences and materials engineering toward the development of tissue substitutes that are capable of mimicking the structure and function of their natural analogues within the body. The general underlying strategy behind the development of tissue engineered organ substitutes is the utilization of a combination of cells, biomaterials, and biochemical cues intended to recreate the natural organ environment. The purpose of this review is to highlight current bioengineering approaches for salivary gland tissue engineering and the adult stem cell sources used for this purpose. Additionally, future considerations in regard to salivary gland tissue engineering strategies are discussed.

No MeSH data available.


Related in: MedlinePlus