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Comparison of the prognosis and recurrence of apparent early-stage ovarian tumors treated with laparoscopy and laparotomy: a meta-analysis of clinical studies.

Zhang Y, Fan S, Xiang Y, Duan H, Sun L - BMC Cancer (2015)

Bottom Line: A total of 8 studies were included in the analysis.The results showed that laparoscopic surgery was significantly associated with lower rates of complications (OR = 0.433, P = 0.019) and shorter postoperative hospital stays (weighted mean difference [WMD] = -0.974, P < 0.001).Laparoscopic surgery shows favorable prognostic outcomes in terms of postoperative complication rates and postoperative hospital stay durations.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology Minimally Invasive Center, Beijing Obstetrics and Gynecology Hospital,Capital Medical University, #17 Qi He Lou Street, Dongcheng District, Beijing, 100006, China. zyandzm@163.com.

ABSTRACT

Background: This meta-analysis aimed to evaluate the prognosis and recurrence of apparent early-stage ovarian tumors treated with laparoscopy compared with laparotomy.

Methods: Clinical studies published in English were retrieved from the computerized databases Medline and Embase. A meta-analysis was performed to investigate the differences in the efficacy and safety of laparoscopy versus laparotomy in terms of postoperative complications, lengths of hospital stay, recurrence rates, and disease-free survival times using the random effects model. The studies were independently reviewed by two investigators. Data from the eligible studies were extracted, and the meta-analysis was performed using the Comprehensive Meta-Analysis program, version 2 (CMA-2; Biostat, Englewood, NJ, USA).

Results: A total of 8 studies were included in the analysis. The results showed that laparoscopic surgery was significantly associated with lower rates of complications (OR = 0.433, P = 0.019) and shorter postoperative hospital stays (weighted mean difference [WMD] = -0.974, P < 0.001). There was no significant difference in the rates of recurrence (OR = 0.707, P = 0.521) between patients with apparent early-stage ovarian tumors who were treated using laparoscopy and those who underwent laparotomy. No publication bias was detected.

Conclusions: Laparoscopic surgery shows favorable prognostic outcomes in terms of postoperative complication rates and postoperative hospital stay durations. Further studies with longer follow-up periods are required to confirm recurrence and survival outcomes after laparoscopic surgery in patients with apparent early-stage ovarian tumors.

No MeSH data available.


Related in: MedlinePlus

Forest plot for the aggregated laparoscopy recurrence rate in patients with apparent early-stage ovarian tumors
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Fig4: Forest plot for the aggregated laparoscopy recurrence rate in patients with apparent early-stage ovarian tumors

Mentions: In the 8 studies that were analyzed, the efficacy and safety of laparoscopy versus laparotomy in the treatment of apparent early-stage ovarian cancer were investigated. The pooled clinical studies that examined the prognosis and recurrence of apparent early-stage ovarian tumors treated with laparoscopy showed that compared with laparotomy, laparoscopic surgery was significantly associated with lower complication rates (OR = 0.433, 95 % CI: 0.215 to 0.869, Z = −2.353, P = 0.019; Fig. 2) and shorter postoperative hospital stays (WMD = −0.974, SE = 0.220, Z = −4.420, P < 0.001; Fig. 3). In terms of recurrence rates, there was no significant difference (OR = 0.707, 95 % CI: 0.245 to 2.037, Z = −0.642, P = 0.521; Fig. 4) between patients with apparent early-stage ovarian tumors who were treated with laparoscopy and those who underwent laparotomy. In Liu’s study (2014), the disease-free survival times were 54.3 months and 57.2 months for patients who were treated with laparoscopy and laparotomy, respectively.Fig. 2


Comparison of the prognosis and recurrence of apparent early-stage ovarian tumors treated with laparoscopy and laparotomy: a meta-analysis of clinical studies.

Zhang Y, Fan S, Xiang Y, Duan H, Sun L - BMC Cancer (2015)

Forest plot for the aggregated laparoscopy recurrence rate in patients with apparent early-stage ovarian tumors
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4549127&req=5

Fig4: Forest plot for the aggregated laparoscopy recurrence rate in patients with apparent early-stage ovarian tumors
Mentions: In the 8 studies that were analyzed, the efficacy and safety of laparoscopy versus laparotomy in the treatment of apparent early-stage ovarian cancer were investigated. The pooled clinical studies that examined the prognosis and recurrence of apparent early-stage ovarian tumors treated with laparoscopy showed that compared with laparotomy, laparoscopic surgery was significantly associated with lower complication rates (OR = 0.433, 95 % CI: 0.215 to 0.869, Z = −2.353, P = 0.019; Fig. 2) and shorter postoperative hospital stays (WMD = −0.974, SE = 0.220, Z = −4.420, P < 0.001; Fig. 3). In terms of recurrence rates, there was no significant difference (OR = 0.707, 95 % CI: 0.245 to 2.037, Z = −0.642, P = 0.521; Fig. 4) between patients with apparent early-stage ovarian tumors who were treated with laparoscopy and those who underwent laparotomy. In Liu’s study (2014), the disease-free survival times were 54.3 months and 57.2 months for patients who were treated with laparoscopy and laparotomy, respectively.Fig. 2

Bottom Line: A total of 8 studies were included in the analysis.The results showed that laparoscopic surgery was significantly associated with lower rates of complications (OR = 0.433, P = 0.019) and shorter postoperative hospital stays (weighted mean difference [WMD] = -0.974, P < 0.001).Laparoscopic surgery shows favorable prognostic outcomes in terms of postoperative complication rates and postoperative hospital stay durations.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology Minimally Invasive Center, Beijing Obstetrics and Gynecology Hospital,Capital Medical University, #17 Qi He Lou Street, Dongcheng District, Beijing, 100006, China. zyandzm@163.com.

ABSTRACT

Background: This meta-analysis aimed to evaluate the prognosis and recurrence of apparent early-stage ovarian tumors treated with laparoscopy compared with laparotomy.

Methods: Clinical studies published in English were retrieved from the computerized databases Medline and Embase. A meta-analysis was performed to investigate the differences in the efficacy and safety of laparoscopy versus laparotomy in terms of postoperative complications, lengths of hospital stay, recurrence rates, and disease-free survival times using the random effects model. The studies were independently reviewed by two investigators. Data from the eligible studies were extracted, and the meta-analysis was performed using the Comprehensive Meta-Analysis program, version 2 (CMA-2; Biostat, Englewood, NJ, USA).

Results: A total of 8 studies were included in the analysis. The results showed that laparoscopic surgery was significantly associated with lower rates of complications (OR = 0.433, P = 0.019) and shorter postoperative hospital stays (weighted mean difference [WMD] = -0.974, P < 0.001). There was no significant difference in the rates of recurrence (OR = 0.707, P = 0.521) between patients with apparent early-stage ovarian tumors who were treated using laparoscopy and those who underwent laparotomy. No publication bias was detected.

Conclusions: Laparoscopic surgery shows favorable prognostic outcomes in terms of postoperative complication rates and postoperative hospital stay durations. Further studies with longer follow-up periods are required to confirm recurrence and survival outcomes after laparoscopic surgery in patients with apparent early-stage ovarian tumors.

No MeSH data available.


Related in: MedlinePlus