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A comparative study between Wuweizi seed and its post-ethanol extraction residue in normal and hypercholesterolemic mice.

Chu ZS, Yu ZL, Pan SY, Jia ZH, Wang XY, Zhang Y, Zhu PL, Wang XJ, Ko KM - Lipids Health Dis (2015)

Bottom Line: FSC-S reduced hepatic GLU level in both normal and HCL mice by 24 and 22 %, respectively.FF supplements reduced serum/hepatic lipids, hepatic GLU contents, and epididymal fat mass, but it induced hepatomegaly and high serum alanine aminotransferase (ALT) activity in normal and/or HCL mice.The ensemble of results indicated that while FSC-SpEt supplementation is beneficial for the treatment of hyperlipidemia/fatty liver, FSC-S is potentially useful for the management of overweight/obesity.

View Article: PubMed Central - PubMed

Affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. chuzhusheng@vip.qq.com.

ABSTRACT

Background: At the present, a shift from drug therapy, especially herbal therapy, to dietary supplementation is a trend in the management of dyslipidemia and related diseases. Therefore, the optimal utilization of herbal resource is important for a sustainable development of herbal medicine. Here, we compared the effects of dietary supplementation with Chinese medicine Schisandrae Chinensis Fructus seed (FSC-S) and the post-ethanol extraction residue of FSC-S (FSC-SpEt) on normal diet-fed (normal) and experimental hypercholesterolemic (HCL) mice.

Methods: Male ICR mice (n = 10 in each group), weighing 17-21 g, were fed with normal diet (ND) or high cholesterol/bile salt (1/0.3 %, w/w) diet (HCBD) with or without supplemented with FSC-S, FSC-SpEt), or lipid-lowering agent fenofibrate (FF). Ten days later, serum/hepatic lipid and glucose (GLU) levels, body weight, organ/epididymal fat masses, and food/water intake were measured. Lipid level measurements included those of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), HDL/LDL ratio, LDL/HDL ratio, and non-HDL (N-HDL).

Results: Supplementation with FSC-S and FSC-SpEt increased serum TC (by 64 and 25 %, respectively) and LDL (by 60 and 27 %, respectively) in normal mice. FSC-S supplementation elevated serum TC, TG, HDL, LDL, and LDL/HDL ratio (up to 64, 118, 77, 197, and 51 %, respectively) in HCL mice. FSC-SpEt supplementation reduced serum TG (by 15 %) and LDL/HDL ratio (by 18 %), as well as increased serum HDL (by 22 %) and HDL/LDL ratio (by 21 %) in HCBD-fed mice. FSC-S decreased hepatic TC (by 19 %) contents and increased hepatic TG contents by 14 % in normal mice. FSC-S reduced hepatic GLU level in both normal and HCL mice by 24 and 22 %, respectively. Hepatic TC and TG contents were lowered in FSC-SpEt-supplemented normal mice by 16 and 20 %, respectively. The body/fatty masse and food intake were lowered, but the feed efficiency index (FEI), weight gain per unit of food ingested, was increased in FSC-S-supplemented normal and HCL mice. FF supplements reduced serum/hepatic lipids, hepatic GLU contents, and epididymal fat mass, but it induced hepatomegaly and high serum alanine aminotransferase (ALT) activity in normal and/or HCL mice.

Conclusion: The ensemble of results indicated that while FSC-SpEt supplementation is beneficial for the treatment of hyperlipidemia/fatty liver, FSC-S is potentially useful for the management of overweight/obesity.

No MeSH data available.


Related in: MedlinePlus

Experimental design of studies on FSC-S and FSC-SpEt in normal and HCL mice. Abbreviations: FSC-S: Fructus Schisandrae Chinensis seed; FSC-SpEt: post-ethanol extraction residue of FSC-S; TC: total cholesterol; TG: triglyceride; LDL: low-density lipoprotein; HDL: high-density lipoprotein; N-HDL: non-HDL; ALT: alanine aminotransferase; HCL: hypercholesterolemia
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Fig1: Experimental design of studies on FSC-S and FSC-SpEt in normal and HCL mice. Abbreviations: FSC-S: Fructus Schisandrae Chinensis seed; FSC-SpEt: post-ethanol extraction residue of FSC-S; TC: total cholesterol; TG: triglyceride; LDL: low-density lipoprotein; HDL: high-density lipoprotein; N-HDL: non-HDL; ALT: alanine aminotransferase; HCL: hypercholesterolemia

Mentions: This study was designed to investigate the effects of FSC-S and FSC-SpEt supplementation on serum and hepatic parameters in HCL mice. Animals were randomly divided into four groups of 10 animals in each: Group 1, mice fed with ND; Group 2, mice fed with high cholesterol/bile salt (1/0.3 %, w/w) diet (HCBD); Group 3, 4, 5, and 6, mice fed with HCBD supplemented with FSC-S (3 %, 9 %) and FSC-SpEt (3 %, 9 %), respectively; Group 7, mice fed with HCBD supplemented with 0.05 % FF. After 10 days of supplementation, mice were sacrificed under light ether anesthesia. Blood samples were collected from the orbital vein, and liver tissue samples were obtained and subjected to biochemical analysis. Figure 1 shows the design of this study.Fig. 1


A comparative study between Wuweizi seed and its post-ethanol extraction residue in normal and hypercholesterolemic mice.

Chu ZS, Yu ZL, Pan SY, Jia ZH, Wang XY, Zhang Y, Zhu PL, Wang XJ, Ko KM - Lipids Health Dis (2015)

Experimental design of studies on FSC-S and FSC-SpEt in normal and HCL mice. Abbreviations: FSC-S: Fructus Schisandrae Chinensis seed; FSC-SpEt: post-ethanol extraction residue of FSC-S; TC: total cholesterol; TG: triglyceride; LDL: low-density lipoprotein; HDL: high-density lipoprotein; N-HDL: non-HDL; ALT: alanine aminotransferase; HCL: hypercholesterolemia
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4549086&req=5

Fig1: Experimental design of studies on FSC-S and FSC-SpEt in normal and HCL mice. Abbreviations: FSC-S: Fructus Schisandrae Chinensis seed; FSC-SpEt: post-ethanol extraction residue of FSC-S; TC: total cholesterol; TG: triglyceride; LDL: low-density lipoprotein; HDL: high-density lipoprotein; N-HDL: non-HDL; ALT: alanine aminotransferase; HCL: hypercholesterolemia
Mentions: This study was designed to investigate the effects of FSC-S and FSC-SpEt supplementation on serum and hepatic parameters in HCL mice. Animals were randomly divided into four groups of 10 animals in each: Group 1, mice fed with ND; Group 2, mice fed with high cholesterol/bile salt (1/0.3 %, w/w) diet (HCBD); Group 3, 4, 5, and 6, mice fed with HCBD supplemented with FSC-S (3 %, 9 %) and FSC-SpEt (3 %, 9 %), respectively; Group 7, mice fed with HCBD supplemented with 0.05 % FF. After 10 days of supplementation, mice were sacrificed under light ether anesthesia. Blood samples were collected from the orbital vein, and liver tissue samples were obtained and subjected to biochemical analysis. Figure 1 shows the design of this study.Fig. 1

Bottom Line: FSC-S reduced hepatic GLU level in both normal and HCL mice by 24 and 22 %, respectively.FF supplements reduced serum/hepatic lipids, hepatic GLU contents, and epididymal fat mass, but it induced hepatomegaly and high serum alanine aminotransferase (ALT) activity in normal and/or HCL mice.The ensemble of results indicated that while FSC-SpEt supplementation is beneficial for the treatment of hyperlipidemia/fatty liver, FSC-S is potentially useful for the management of overweight/obesity.

View Article: PubMed Central - PubMed

Affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. chuzhusheng@vip.qq.com.

ABSTRACT

Background: At the present, a shift from drug therapy, especially herbal therapy, to dietary supplementation is a trend in the management of dyslipidemia and related diseases. Therefore, the optimal utilization of herbal resource is important for a sustainable development of herbal medicine. Here, we compared the effects of dietary supplementation with Chinese medicine Schisandrae Chinensis Fructus seed (FSC-S) and the post-ethanol extraction residue of FSC-S (FSC-SpEt) on normal diet-fed (normal) and experimental hypercholesterolemic (HCL) mice.

Methods: Male ICR mice (n = 10 in each group), weighing 17-21 g, were fed with normal diet (ND) or high cholesterol/bile salt (1/0.3 %, w/w) diet (HCBD) with or without supplemented with FSC-S, FSC-SpEt), or lipid-lowering agent fenofibrate (FF). Ten days later, serum/hepatic lipid and glucose (GLU) levels, body weight, organ/epididymal fat masses, and food/water intake were measured. Lipid level measurements included those of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), HDL/LDL ratio, LDL/HDL ratio, and non-HDL (N-HDL).

Results: Supplementation with FSC-S and FSC-SpEt increased serum TC (by 64 and 25 %, respectively) and LDL (by 60 and 27 %, respectively) in normal mice. FSC-S supplementation elevated serum TC, TG, HDL, LDL, and LDL/HDL ratio (up to 64, 118, 77, 197, and 51 %, respectively) in HCL mice. FSC-SpEt supplementation reduced serum TG (by 15 %) and LDL/HDL ratio (by 18 %), as well as increased serum HDL (by 22 %) and HDL/LDL ratio (by 21 %) in HCBD-fed mice. FSC-S decreased hepatic TC (by 19 %) contents and increased hepatic TG contents by 14 % in normal mice. FSC-S reduced hepatic GLU level in both normal and HCL mice by 24 and 22 %, respectively. Hepatic TC and TG contents were lowered in FSC-SpEt-supplemented normal mice by 16 and 20 %, respectively. The body/fatty masse and food intake were lowered, but the feed efficiency index (FEI), weight gain per unit of food ingested, was increased in FSC-S-supplemented normal and HCL mice. FF supplements reduced serum/hepatic lipids, hepatic GLU contents, and epididymal fat mass, but it induced hepatomegaly and high serum alanine aminotransferase (ALT) activity in normal and/or HCL mice.

Conclusion: The ensemble of results indicated that while FSC-SpEt supplementation is beneficial for the treatment of hyperlipidemia/fatty liver, FSC-S is potentially useful for the management of overweight/obesity.

No MeSH data available.


Related in: MedlinePlus