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Immunological events in chronic spontaneous urticaria.

Ferrer M - Clin Transl Allergy (2015)

Bottom Line: Chronic spontaneous urticaria (CSU) is a highly debilitating skin disease associated with systemic features.We have made significant progress in several aspects relating to this condition.All these facts orchestrate a systemic inflammation response producing a significant increase of several inflammatory markers.

View Article: PubMed Central - PubMed

Affiliation: Department of Allergy and Clinical Immunology, Clinica Universidad de Navarra, Pio XII, 36, 31008 Pamplona, Spain.

ABSTRACT
Chronic spontaneous urticaria (CSU) is a highly debilitating skin disease associated with systemic features. We have made significant progress in several aspects relating to this condition. However, the exact physiopathology remains unknown. There is mounting evidence for an autoimmune basis, demonstrated by the CSU serum ability to activate healthy donors skin mast cells and blood basophils. However, it is only seen among 35-40% of patients. Mast cells and basophils play an important role in this skin condition. Both cells in CSU patients have unique features that differentiate them from basophils and mast cells from healthy donors. In the case of basophils, basopenia is typically found in CSU patients. Basophils from CSU patients also tend to be hyporesponsive to stimuli that act through the IgE receptor, responsive to other stimuli as MCP-1 or C5a, and hyperesponsive when incubated with sera. Eosinophils are also present in CSU skin biopsies, yet their exact role has not yet been defined. Likewise, endothelial cells also play a function, as indirectly demonstrated by an increase of vasoactive peptides in skin and plasma of CSU patients' samples. All these facts orchestrate a systemic inflammation response producing a significant increase of several inflammatory markers. Unfortunately, we lack a unitary model that could explain the exact role of each of these players. In this review, we will describe the history and discover the pathway to the present knowledge on the immunological facts of this disease.

No MeSH data available.


Related in: MedlinePlus

We represent in a very simplistic cartoon the possible ways of activation among cells implicated in this disease. Cross-talk between mast cells and basophils remain to be defined.
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Fig1: We represent in a very simplistic cartoon the possible ways of activation among cells implicated in this disease. Cross-talk between mast cells and basophils remain to be defined.

Mentions: The real significance of these facts in the pathogenesis of CSU is not well understood. However, they could amplify the inflammation inducing vascular permeability. Furthermore, some cascade proteins are able to induce mast cell degranulation (we include a summary of these pathways and cell cross-talk in Fig. 1).Fig. 1


Immunological events in chronic spontaneous urticaria.

Ferrer M - Clin Transl Allergy (2015)

We represent in a very simplistic cartoon the possible ways of activation among cells implicated in this disease. Cross-talk between mast cells and basophils remain to be defined.
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4549074&req=5

Fig1: We represent in a very simplistic cartoon the possible ways of activation among cells implicated in this disease. Cross-talk between mast cells and basophils remain to be defined.
Mentions: The real significance of these facts in the pathogenesis of CSU is not well understood. However, they could amplify the inflammation inducing vascular permeability. Furthermore, some cascade proteins are able to induce mast cell degranulation (we include a summary of these pathways and cell cross-talk in Fig. 1).Fig. 1

Bottom Line: Chronic spontaneous urticaria (CSU) is a highly debilitating skin disease associated with systemic features.We have made significant progress in several aspects relating to this condition.All these facts orchestrate a systemic inflammation response producing a significant increase of several inflammatory markers.

View Article: PubMed Central - PubMed

Affiliation: Department of Allergy and Clinical Immunology, Clinica Universidad de Navarra, Pio XII, 36, 31008 Pamplona, Spain.

ABSTRACT
Chronic spontaneous urticaria (CSU) is a highly debilitating skin disease associated with systemic features. We have made significant progress in several aspects relating to this condition. However, the exact physiopathology remains unknown. There is mounting evidence for an autoimmune basis, demonstrated by the CSU serum ability to activate healthy donors skin mast cells and blood basophils. However, it is only seen among 35-40% of patients. Mast cells and basophils play an important role in this skin condition. Both cells in CSU patients have unique features that differentiate them from basophils and mast cells from healthy donors. In the case of basophils, basopenia is typically found in CSU patients. Basophils from CSU patients also tend to be hyporesponsive to stimuli that act through the IgE receptor, responsive to other stimuli as MCP-1 or C5a, and hyperesponsive when incubated with sera. Eosinophils are also present in CSU skin biopsies, yet their exact role has not yet been defined. Likewise, endothelial cells also play a function, as indirectly demonstrated by an increase of vasoactive peptides in skin and plasma of CSU patients' samples. All these facts orchestrate a systemic inflammation response producing a significant increase of several inflammatory markers. Unfortunately, we lack a unitary model that could explain the exact role of each of these players. In this review, we will describe the history and discover the pathway to the present knowledge on the immunological facts of this disease.

No MeSH data available.


Related in: MedlinePlus