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Lymphangiogenic Markers and Their Impact on Nodal Metastasis and Survival in Non-Small Cell Lung Cancer--A Structured Review with Meta-Analysis.

Kilvaer TK, Paulsen EE, Hald SM, Wilsgaard T, Bremnes RM, Busund LT, Donnem T - PLoS ONE (2015)

Bottom Line: However, study results differ.High levels of vascular endothelial growth factor C (VEGF-C, HR 1.57 95% CI 1.34-1.84) and high lymphatic vascular density (LVD, HR 1.84 95% CI 1.18-2.87) were significant prognostic markers of poor survival and high expression of VEGF-C, vascular endothelial growth factor receptor 3 (VEGFR3) and LVD was associated with lymph node metastasis in NSCLC.Their exact role and clinical implications should be further elucidated.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, University Hospital of North Norway, Tromso, Norway; Institute of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway.

ABSTRACT

Background: In non-small cell lung cancer (NSCLC), nodal metastasis is an adverse prognostic factor. Several mediating factors have been implied in the development of nodal metastases and investigated for predictive and prognostic properties in NSCLC. However, study results differ. In this structured review and meta-analysis we explore the published literature on commonly recognized pathways for molecular regulation of lymphatic metastasis in NSCLC.

Methods: A structured PubMed search was conducted for papers reporting on the expression of known markers of lymhangiogenesis in NSCLC patients. Papers of sufficient quality, presenting survival and/or correlation data were included.

Results: High levels of vascular endothelial growth factor C (VEGF-C, HR 1.57 95% CI 1.34-1.84) and high lymphatic vascular density (LVD, HR 1.84 95% CI 1.18-2.87) were significant prognostic markers of poor survival and high expression of VEGF-C, vascular endothelial growth factor receptor 3 (VEGFR3) and LVD was associated with lymph node metastasis in NSCLC.

Conclusion: Lymphangiogenic markers are prognosticators of survival and correlate with lymph node metastasis in NSCLC. Their exact role and clinical implications should be further elucidated.

No MeSH data available.


Related in: MedlinePlus

Forest plots of the survival meta-analyses for; A) VEGF-C, B) VEGF-D, C) VEGFR3, D) LVD, Funnel plots showing the relationship between the observed HR and the standard deviation in the survival meta-analyses for; E) VEGFR3, F) LVD.Abbreviations: VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor receptor; LVD, lymphatic vascular density; N, number: HR, hazard ratio.
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pone.0132481.g002: Forest plots of the survival meta-analyses for; A) VEGF-C, B) VEGF-D, C) VEGFR3, D) LVD, Funnel plots showing the relationship between the observed HR and the standard deviation in the survival meta-analyses for; E) VEGFR3, F) LVD.Abbreviations: VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor receptor; LVD, lymphatic vascular density; N, number: HR, hazard ratio.

Mentions: The results of the meta-analyses are summarized in Figs 2 and 3 and Table 3, while the individual univariate HRs, calculated or as reported, are given in Table 1.


Lymphangiogenic Markers and Their Impact on Nodal Metastasis and Survival in Non-Small Cell Lung Cancer--A Structured Review with Meta-Analysis.

Kilvaer TK, Paulsen EE, Hald SM, Wilsgaard T, Bremnes RM, Busund LT, Donnem T - PLoS ONE (2015)

Forest plots of the survival meta-analyses for; A) VEGF-C, B) VEGF-D, C) VEGFR3, D) LVD, Funnel plots showing the relationship between the observed HR and the standard deviation in the survival meta-analyses for; E) VEGFR3, F) LVD.Abbreviations: VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor receptor; LVD, lymphatic vascular density; N, number: HR, hazard ratio.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4549062&req=5

pone.0132481.g002: Forest plots of the survival meta-analyses for; A) VEGF-C, B) VEGF-D, C) VEGFR3, D) LVD, Funnel plots showing the relationship between the observed HR and the standard deviation in the survival meta-analyses for; E) VEGFR3, F) LVD.Abbreviations: VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor receptor; LVD, lymphatic vascular density; N, number: HR, hazard ratio.
Mentions: The results of the meta-analyses are summarized in Figs 2 and 3 and Table 3, while the individual univariate HRs, calculated or as reported, are given in Table 1.

Bottom Line: However, study results differ.High levels of vascular endothelial growth factor C (VEGF-C, HR 1.57 95% CI 1.34-1.84) and high lymphatic vascular density (LVD, HR 1.84 95% CI 1.18-2.87) were significant prognostic markers of poor survival and high expression of VEGF-C, vascular endothelial growth factor receptor 3 (VEGFR3) and LVD was associated with lymph node metastasis in NSCLC.Their exact role and clinical implications should be further elucidated.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, University Hospital of North Norway, Tromso, Norway; Institute of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway.

ABSTRACT

Background: In non-small cell lung cancer (NSCLC), nodal metastasis is an adverse prognostic factor. Several mediating factors have been implied in the development of nodal metastases and investigated for predictive and prognostic properties in NSCLC. However, study results differ. In this structured review and meta-analysis we explore the published literature on commonly recognized pathways for molecular regulation of lymphatic metastasis in NSCLC.

Methods: A structured PubMed search was conducted for papers reporting on the expression of known markers of lymhangiogenesis in NSCLC patients. Papers of sufficient quality, presenting survival and/or correlation data were included.

Results: High levels of vascular endothelial growth factor C (VEGF-C, HR 1.57 95% CI 1.34-1.84) and high lymphatic vascular density (LVD, HR 1.84 95% CI 1.18-2.87) were significant prognostic markers of poor survival and high expression of VEGF-C, vascular endothelial growth factor receptor 3 (VEGFR3) and LVD was associated with lymph node metastasis in NSCLC.

Conclusion: Lymphangiogenic markers are prognosticators of survival and correlate with lymph node metastasis in NSCLC. Their exact role and clinical implications should be further elucidated.

No MeSH data available.


Related in: MedlinePlus