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Cardiac telocytes are double positive for CD34/PDGFR-α.

Zhou Q, Wei L, Zhong C, Fu S, Bei Y, Huică RI, Wang F, Xiao J - J. Cell. Mol. Med. (2015)

Bottom Line: It has recently been proposed that CD34/PDGFR-α (Platelet-derived growth factor receptor α) is actually a specific marker for TCs including cardiac TCs although the direct evidence is still lacking.We show that cardiac TCs are double positive for CD34/PDGFR-α.Better understanding of the immunocytochemical phenotypes of cardiac TCs might help using cardiac TCs as a novel source in cardiac repair.

View Article: PubMed Central - PubMed

Affiliation: Regeneration and Ageing Lab, Experimental Center of Life Sciences, School of Life Science, Shanghai University, Shanghai, China.

No MeSH data available.


CD34, PDGFR-α and PDGFR-β expression (positive cells percentages relative to the whole population in TC-enriched stromal cells from rat heart). The relative expression of three markers is shown for four experiments, as percentage of positive cells for CD34, PDGFR-α and PDGFR-β respectively, in relation to the whole (‘Parent’) cell population.
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fig07: CD34, PDGFR-α and PDGFR-β expression (positive cells percentages relative to the whole population in TC-enriched stromal cells from rat heart). The relative expression of three markers is shown for four experiments, as percentage of positive cells for CD34, PDGFR-α and PDGFR-β respectively, in relation to the whole (‘Parent’) cell population.

Mentions: CD34, PDGFR-α and PDGFR-β expression levels in the whole cell population are shown in Figure7 as percentage positive of the whole cell population. The PDGFR-α+ population varied from 80% to 91% of the total number of cells, with an average value of 87%. The CD34+/PDGFR-α+ population varied from 29% to 41%, while CD34+/PDGFR-β+ represented 28–36% (data not shown). The entire cell population shows a high expression level for PDGFR-α (‘bright’ events) and a lower expression level for CD34 and PDGFR-β (‘dim’ events; Fig.8). CD34/PDGFR-α positive events accounted for 30.25% of the cell population (data not shown).


Cardiac telocytes are double positive for CD34/PDGFR-α.

Zhou Q, Wei L, Zhong C, Fu S, Bei Y, Huică RI, Wang F, Xiao J - J. Cell. Mol. Med. (2015)

CD34, PDGFR-α and PDGFR-β expression (positive cells percentages relative to the whole population in TC-enriched stromal cells from rat heart). The relative expression of three markers is shown for four experiments, as percentage of positive cells for CD34, PDGFR-α and PDGFR-β respectively, in relation to the whole (‘Parent’) cell population.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4549054&req=5

fig07: CD34, PDGFR-α and PDGFR-β expression (positive cells percentages relative to the whole population in TC-enriched stromal cells from rat heart). The relative expression of three markers is shown for four experiments, as percentage of positive cells for CD34, PDGFR-α and PDGFR-β respectively, in relation to the whole (‘Parent’) cell population.
Mentions: CD34, PDGFR-α and PDGFR-β expression levels in the whole cell population are shown in Figure7 as percentage positive of the whole cell population. The PDGFR-α+ population varied from 80% to 91% of the total number of cells, with an average value of 87%. The CD34+/PDGFR-α+ population varied from 29% to 41%, while CD34+/PDGFR-β+ represented 28–36% (data not shown). The entire cell population shows a high expression level for PDGFR-α (‘bright’ events) and a lower expression level for CD34 and PDGFR-β (‘dim’ events; Fig.8). CD34/PDGFR-α positive events accounted for 30.25% of the cell population (data not shown).

Bottom Line: It has recently been proposed that CD34/PDGFR-α (Platelet-derived growth factor receptor α) is actually a specific marker for TCs including cardiac TCs although the direct evidence is still lacking.We show that cardiac TCs are double positive for CD34/PDGFR-α.Better understanding of the immunocytochemical phenotypes of cardiac TCs might help using cardiac TCs as a novel source in cardiac repair.

View Article: PubMed Central - PubMed

Affiliation: Regeneration and Ageing Lab, Experimental Center of Life Sciences, School of Life Science, Shanghai University, Shanghai, China.

No MeSH data available.