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Cardiac telocytes are double positive for CD34/PDGFR-α.

Zhou Q, Wei L, Zhong C, Fu S, Bei Y, Huică RI, Wang F, Xiao J - J. Cell. Mol. Med. (2015)

Bottom Line: It has recently been proposed that CD34/PDGFR-α (Platelet-derived growth factor receptor α) is actually a specific marker for TCs including cardiac TCs although the direct evidence is still lacking.We show that cardiac TCs are double positive for CD34/PDGFR-α.Better understanding of the immunocytochemical phenotypes of cardiac TCs might help using cardiac TCs as a novel source in cardiac repair.

View Article: PubMed Central - PubMed

Affiliation: Regeneration and Ageing Lab, Experimental Center of Life Sciences, School of Life Science, Shanghai University, Shanghai, China.

No MeSH data available.


CD34/PDGFR-α positive cells (putative cardiac TCs) exist in human cardiac valves. Double immunofluorescence labelling for CD34 (red) and PDGFR-α (green) with DAPI (blue) counterstain for nuclei shows that CD34/PDGFR-α positive cells (putative cardiac TCs) exist in human atrium and cardiac valves including mitral valve (hMV), tricuspid valve (hTV) and aortic valve (hAV); scale bar = 20 μm.
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fig05: CD34/PDGFR-α positive cells (putative cardiac TCs) exist in human cardiac valves. Double immunofluorescence labelling for CD34 (red) and PDGFR-α (green) with DAPI (blue) counterstain for nuclei shows that CD34/PDGFR-α positive cells (putative cardiac TCs) exist in human atrium and cardiac valves including mitral valve (hMV), tricuspid valve (hTV) and aortic valve (hAV); scale bar = 20 μm.

Mentions: To further explore if CD34/PDGFR-α positive cells (putative cardiac TCs) exist, we checked the samples from mice ventricle firstly. We identified CD34/PDGFR-α positive cells (putative cardiac TCs) in mice ventricle (Fig.4). Besides, we also explored their existence in human cardiac valves. We found that CD34/PDGFR-α positive cells (putative cardiac TCs) existed in human cardiac valves including mitral valve, tricuspid valve and aortic valve (Fig.5).


Cardiac telocytes are double positive for CD34/PDGFR-α.

Zhou Q, Wei L, Zhong C, Fu S, Bei Y, Huică RI, Wang F, Xiao J - J. Cell. Mol. Med. (2015)

CD34/PDGFR-α positive cells (putative cardiac TCs) exist in human cardiac valves. Double immunofluorescence labelling for CD34 (red) and PDGFR-α (green) with DAPI (blue) counterstain for nuclei shows that CD34/PDGFR-α positive cells (putative cardiac TCs) exist in human atrium and cardiac valves including mitral valve (hMV), tricuspid valve (hTV) and aortic valve (hAV); scale bar = 20 μm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4549054&req=5

fig05: CD34/PDGFR-α positive cells (putative cardiac TCs) exist in human cardiac valves. Double immunofluorescence labelling for CD34 (red) and PDGFR-α (green) with DAPI (blue) counterstain for nuclei shows that CD34/PDGFR-α positive cells (putative cardiac TCs) exist in human atrium and cardiac valves including mitral valve (hMV), tricuspid valve (hTV) and aortic valve (hAV); scale bar = 20 μm.
Mentions: To further explore if CD34/PDGFR-α positive cells (putative cardiac TCs) exist, we checked the samples from mice ventricle firstly. We identified CD34/PDGFR-α positive cells (putative cardiac TCs) in mice ventricle (Fig.4). Besides, we also explored their existence in human cardiac valves. We found that CD34/PDGFR-α positive cells (putative cardiac TCs) existed in human cardiac valves including mitral valve, tricuspid valve and aortic valve (Fig.5).

Bottom Line: It has recently been proposed that CD34/PDGFR-α (Platelet-derived growth factor receptor α) is actually a specific marker for TCs including cardiac TCs although the direct evidence is still lacking.We show that cardiac TCs are double positive for CD34/PDGFR-α.Better understanding of the immunocytochemical phenotypes of cardiac TCs might help using cardiac TCs as a novel source in cardiac repair.

View Article: PubMed Central - PubMed

Affiliation: Regeneration and Ageing Lab, Experimental Center of Life Sciences, School of Life Science, Shanghai University, Shanghai, China.

No MeSH data available.