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The CD4(+) AT2R(+) T cell subpopulation improves post-infarction remodelling and restores cardiac function.

Skorska A, von Haehling S, Ludwig M, Lux CA, Gaebel R, Kleiner G, Klopsch C, Dong J, Curato C, Altarche-Xifró W, Slavic S, Unger T, Steinhoff G, Li J, David R - J. Cell. Mol. Med. (2015)

Bottom Line: Flow cytometric analyses showed an increase in the expression of CD4(+) AT2R(+) cells in the rat heart and spleen post-infarction, but a reduction in the peripheral blood.Furthermore, intramyocardial injection of MI-induced splenic CD4(+) AT2R(+) T cells into recipient rats with MI led to reduced infarct size and improved cardiac performance.Our results indicate CD4(+) AT2R(+) cells as a promising population for regenerative therapy, via myocardial transplantation, pharmacological AT2R activation or a combination thereof.

View Article: PubMed Central - PubMed

Affiliation: Reference and Translation Centre for Cardiac Stem Cell Therapy (RTC)/Department of Cardiac Surgery, University of Rostock, Rostock, Germany.

No MeSH data available.


Related in: MedlinePlus

Distribution of the CD4+ AT2R+ T cells within CD4+ CD44+ CD62L− or CD4+ CD44+ CD62L+ T cell subsets A. A decreased frequency of CD4+ AT2R+ T cells within the CD4+ CD44+ CD62L− cell subset was observed in patients with HF. No significant difference was detected within the CD4+ CD44+ CD62L+ T cell subset (B). ns, not significant; *P < 0.05, n = 5.
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fig04: Distribution of the CD4+ AT2R+ T cells within CD4+ CD44+ CD62L− or CD4+ CD44+ CD62L+ T cell subsets A. A decreased frequency of CD4+ AT2R+ T cells within the CD4+ CD44+ CD62L− cell subset was observed in patients with HF. No significant difference was detected within the CD4+ CD44+ CD62L+ T cell subset (B). ns, not significant; *P < 0.05, n = 5.

Mentions: A further detailed analysis of the distribution of CD4+ AT2R+ T cells within CD4+ CD44+ CD62L− or CD4+ CD44+ CD62L+ T cell subsets (Fig.4A and B) showed that a significant decrease of blood CD4+ AT2R+ T cells in patients with HF was exclusively assigned to the CD4+ CD44+ CD62L− T cell subset, a known activated T cell fraction located mainly at inflammatory sites 22.


The CD4(+) AT2R(+) T cell subpopulation improves post-infarction remodelling and restores cardiac function.

Skorska A, von Haehling S, Ludwig M, Lux CA, Gaebel R, Kleiner G, Klopsch C, Dong J, Curato C, Altarche-Xifró W, Slavic S, Unger T, Steinhoff G, Li J, David R - J. Cell. Mol. Med. (2015)

Distribution of the CD4+ AT2R+ T cells within CD4+ CD44+ CD62L− or CD4+ CD44+ CD62L+ T cell subsets A. A decreased frequency of CD4+ AT2R+ T cells within the CD4+ CD44+ CD62L− cell subset was observed in patients with HF. No significant difference was detected within the CD4+ CD44+ CD62L+ T cell subset (B). ns, not significant; *P < 0.05, n = 5.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4549048&req=5

fig04: Distribution of the CD4+ AT2R+ T cells within CD4+ CD44+ CD62L− or CD4+ CD44+ CD62L+ T cell subsets A. A decreased frequency of CD4+ AT2R+ T cells within the CD4+ CD44+ CD62L− cell subset was observed in patients with HF. No significant difference was detected within the CD4+ CD44+ CD62L+ T cell subset (B). ns, not significant; *P < 0.05, n = 5.
Mentions: A further detailed analysis of the distribution of CD4+ AT2R+ T cells within CD4+ CD44+ CD62L− or CD4+ CD44+ CD62L+ T cell subsets (Fig.4A and B) showed that a significant decrease of blood CD4+ AT2R+ T cells in patients with HF was exclusively assigned to the CD4+ CD44+ CD62L− T cell subset, a known activated T cell fraction located mainly at inflammatory sites 22.

Bottom Line: Flow cytometric analyses showed an increase in the expression of CD4(+) AT2R(+) cells in the rat heart and spleen post-infarction, but a reduction in the peripheral blood.Furthermore, intramyocardial injection of MI-induced splenic CD4(+) AT2R(+) T cells into recipient rats with MI led to reduced infarct size and improved cardiac performance.Our results indicate CD4(+) AT2R(+) cells as a promising population for regenerative therapy, via myocardial transplantation, pharmacological AT2R activation or a combination thereof.

View Article: PubMed Central - PubMed

Affiliation: Reference and Translation Centre for Cardiac Stem Cell Therapy (RTC)/Department of Cardiac Surgery, University of Rostock, Rostock, Germany.

No MeSH data available.


Related in: MedlinePlus