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Perinatally administered losartan augments renal ACE2 expression but not cardiac or renal Mas receptor in spontaneously hypertensive rats.

Klimas J, Olvedy M, Ochodnicka-Mackovicova K, Kruzliak P, Cacanyiova S, Kristek F, Krenek P, Ochodnicky P - J. Cell. Mol. Med. (2015)

Bottom Line: In the hypertrophied left ventricle of SHR, cardiac expressions of Ace and Mas were decreased while those of AT1 receptor (Agtr1a) and Ace2 were unchanged.Continuous losartan administration reduced LV weight (0.43 ± 0.02; P < 0.05 versus SHR) but did not influence altered cardiac RAS expression.Increased blood pressure in SHR (149 ± 2 in SHR versus 109 ± 2 mmHg in Wistar; P < 0.05) was associated with a lower renal expressions of renin, Agtr1a and Mas and with an increase in ACE2.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Bratislava, Slovakia.

No MeSH data available.


Related in: MedlinePlus

mRNA expression of components of the local renin–angiotensin system components in the kidney. Ace: angiotensin I converting enzyme; Ace2: angiotensin I converting enzyme 2; Agtr1a: angiotensin II receptor, type 1a; Mas1: MAS1 proto-oncogene, G protein-coupled receptor; Ren1: renin. Mean ± SEM (n = 7?9 per group; *P < 0.05 versus CON, #P < 0.05 versus CON, #P < 0.05 versus SHR).
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fig04: mRNA expression of components of the local renin–angiotensin system components in the kidney. Ace: angiotensin I converting enzyme; Ace2: angiotensin I converting enzyme 2; Agtr1a: angiotensin II receptor, type 1a; Mas1: MAS1 proto-oncogene, G protein-coupled receptor; Ren1: renin. Mean ± SEM (n = 7?9 per group; *P < 0.05 versus CON, #P < 0.05 versus CON, #P < 0.05 versus SHR).

Mentions: As kidneys are substantial regulators of blood pressure, we analysed local RAS components also in renal tissue (see Fig.4). Similar to LV mRNA expressions, we found lower levels of ACE and MAS receptor mRNA in the SHR. However, in contrast to the left ventricle, we observed significantly decreased mRNA level of AT1 receptor but a significant increase in ACE2.


Perinatally administered losartan augments renal ACE2 expression but not cardiac or renal Mas receptor in spontaneously hypertensive rats.

Klimas J, Olvedy M, Ochodnicka-Mackovicova K, Kruzliak P, Cacanyiova S, Kristek F, Krenek P, Ochodnicky P - J. Cell. Mol. Med. (2015)

mRNA expression of components of the local renin–angiotensin system components in the kidney. Ace: angiotensin I converting enzyme; Ace2: angiotensin I converting enzyme 2; Agtr1a: angiotensin II receptor, type 1a; Mas1: MAS1 proto-oncogene, G protein-coupled receptor; Ren1: renin. Mean ± SEM (n = 7?9 per group; *P < 0.05 versus CON, #P < 0.05 versus CON, #P < 0.05 versus SHR).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4549047&req=5

fig04: mRNA expression of components of the local renin–angiotensin system components in the kidney. Ace: angiotensin I converting enzyme; Ace2: angiotensin I converting enzyme 2; Agtr1a: angiotensin II receptor, type 1a; Mas1: MAS1 proto-oncogene, G protein-coupled receptor; Ren1: renin. Mean ± SEM (n = 7?9 per group; *P < 0.05 versus CON, #P < 0.05 versus CON, #P < 0.05 versus SHR).
Mentions: As kidneys are substantial regulators of blood pressure, we analysed local RAS components also in renal tissue (see Fig.4). Similar to LV mRNA expressions, we found lower levels of ACE and MAS receptor mRNA in the SHR. However, in contrast to the left ventricle, we observed significantly decreased mRNA level of AT1 receptor but a significant increase in ACE2.

Bottom Line: In the hypertrophied left ventricle of SHR, cardiac expressions of Ace and Mas were decreased while those of AT1 receptor (Agtr1a) and Ace2 were unchanged.Continuous losartan administration reduced LV weight (0.43 ± 0.02; P < 0.05 versus SHR) but did not influence altered cardiac RAS expression.Increased blood pressure in SHR (149 ± 2 in SHR versus 109 ± 2 mmHg in Wistar; P < 0.05) was associated with a lower renal expressions of renin, Agtr1a and Mas and with an increase in ACE2.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Bratislava, Slovakia.

No MeSH data available.


Related in: MedlinePlus