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Perinatally administered losartan augments renal ACE2 expression but not cardiac or renal Mas receptor in spontaneously hypertensive rats.

Klimas J, Olvedy M, Ochodnicka-Mackovicova K, Kruzliak P, Cacanyiova S, Kristek F, Krenek P, Ochodnicky P - J. Cell. Mol. Med. (2015)

Bottom Line: In the hypertrophied left ventricle of SHR, cardiac expressions of Ace and Mas were decreased while those of AT1 receptor (Agtr1a) and Ace2 were unchanged.Continuous losartan administration reduced LV weight (0.43 ± 0.02; P < 0.05 versus SHR) but did not influence altered cardiac RAS expression.Increased blood pressure in SHR (149 ± 2 in SHR versus 109 ± 2 mmHg in Wistar; P < 0.05) was associated with a lower renal expressions of renin, Agtr1a and Mas and with an increase in ACE2.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Bratislava, Slovakia.

No MeSH data available.


Related in: MedlinePlus

mRNA expression of components of the local renin–angiotensin system in the left ventricle. Ace: angiotensin I converting enzyme; Ace2: angiotensin I converting enzyme 2; Agtr1a: angiotensin II receptor, type 1a; Mas1: MAS1 proto-oncogene, G protein-coupled receptor. Mean ± SEM (n = 7?9 per group; *P < 0.05 versus CON).
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fig02: mRNA expression of components of the local renin–angiotensin system in the left ventricle. Ace: angiotensin I converting enzyme; Ace2: angiotensin I converting enzyme 2; Agtr1a: angiotensin II receptor, type 1a; Mas1: MAS1 proto-oncogene, G protein-coupled receptor. Mean ± SEM (n = 7?9 per group; *P < 0.05 versus CON).

Mentions: LV hypertrophy in SHR was characterized by a decreased mRNA expression of Ace and Mas receptor genes while no changes were detected in mRNA expressions of Ace2 and of AT1 receptor genes (see Fig.2). Neither continuous (see Fig.2) nor transient (data not shown) losartan administration had any influence on these changes.


Perinatally administered losartan augments renal ACE2 expression but not cardiac or renal Mas receptor in spontaneously hypertensive rats.

Klimas J, Olvedy M, Ochodnicka-Mackovicova K, Kruzliak P, Cacanyiova S, Kristek F, Krenek P, Ochodnicky P - J. Cell. Mol. Med. (2015)

mRNA expression of components of the local renin–angiotensin system in the left ventricle. Ace: angiotensin I converting enzyme; Ace2: angiotensin I converting enzyme 2; Agtr1a: angiotensin II receptor, type 1a; Mas1: MAS1 proto-oncogene, G protein-coupled receptor. Mean ± SEM (n = 7?9 per group; *P < 0.05 versus CON).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4549047&req=5

fig02: mRNA expression of components of the local renin–angiotensin system in the left ventricle. Ace: angiotensin I converting enzyme; Ace2: angiotensin I converting enzyme 2; Agtr1a: angiotensin II receptor, type 1a; Mas1: MAS1 proto-oncogene, G protein-coupled receptor. Mean ± SEM (n = 7?9 per group; *P < 0.05 versus CON).
Mentions: LV hypertrophy in SHR was characterized by a decreased mRNA expression of Ace and Mas receptor genes while no changes were detected in mRNA expressions of Ace2 and of AT1 receptor genes (see Fig.2). Neither continuous (see Fig.2) nor transient (data not shown) losartan administration had any influence on these changes.

Bottom Line: In the hypertrophied left ventricle of SHR, cardiac expressions of Ace and Mas were decreased while those of AT1 receptor (Agtr1a) and Ace2 were unchanged.Continuous losartan administration reduced LV weight (0.43 ± 0.02; P < 0.05 versus SHR) but did not influence altered cardiac RAS expression.Increased blood pressure in SHR (149 ± 2 in SHR versus 109 ± 2 mmHg in Wistar; P < 0.05) was associated with a lower renal expressions of renin, Agtr1a and Mas and with an increase in ACE2.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Bratislava, Slovakia.

No MeSH data available.


Related in: MedlinePlus