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Beneficial effects of intramyocardial mesenchymal stem cells and VEGF165 plasmid injection in rats with furazolidone induced dilated cardiomyopathy.

Yu Q, Fang W, Zhu N, Zheng X, Na R, Liu B, Meng L, Li Z, Li Q, Li X - J. Cell. Mol. Med. (2015)

Bottom Line: Cardiac function was improved in MSCs, GENE and MSCs+GENE groups.Collagen volume fraction was significantly reduced and myocardial TGF-β1 mRNA expression significantly down-regulated in both GENE and MSCs+GENE groups, collagen type I/III ratio reduction was more significant in MSCs+GENE group than in MSCs or GENE group.Myocardial MSCs and hVEGF165 plasmid injection improves cardiac function possibly through down-regulating myocardial TGF-β1 expression and reducing the type I/III collagen ratio in this DCM rat model.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.

No MeSH data available.


Related in: MedlinePlus

(A) Massion staining. (a) PBS; (b) MSCs; (c) GENE; (d) MSCs+GENE. Bar plots of collagen volume fraction in respective groups (right). (B) Sirius red staining. (a) PBS; (b) MSCs; (c) GENE; (d) MSCs+GENE. Bar plots of collagen volume fraction in respective groups (right). Note that CVF was significantly reduced in MSCs and GENE groups and further reduced in MSCs+GENE group compared to PBS group. Bonferroni adjusted *P < 0.01 versus PSB; †P < 0.01 versus GENE; ‡P < 0.05 versus 8 weeks.
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fig03: (A) Massion staining. (a) PBS; (b) MSCs; (c) GENE; (d) MSCs+GENE. Bar plots of collagen volume fraction in respective groups (right). (B) Sirius red staining. (a) PBS; (b) MSCs; (c) GENE; (d) MSCs+GENE. Bar plots of collagen volume fraction in respective groups (right). Note that CVF was significantly reduced in MSCs and GENE groups and further reduced in MSCs+GENE group compared to PBS group. Bonferroni adjusted *P < 0.01 versus PSB; †P < 0.01 versus GENE; ‡P < 0.05 versus 8 weeks.

Mentions: Collagen volume fraction was significantly reduced in MSCs and GENE group and further reduced in MSCs plus GENE group compared to PBS group at the end of study (Fig.3A: Massion staining and Fig.3B: Sirius red staining). von Willebrand factor staining showed a tendency for increased vWF expression in MSCs and GENE group and which was significantly up-regulated in MSCs+GENE group compared to PBS group (Fig.4).


Beneficial effects of intramyocardial mesenchymal stem cells and VEGF165 plasmid injection in rats with furazolidone induced dilated cardiomyopathy.

Yu Q, Fang W, Zhu N, Zheng X, Na R, Liu B, Meng L, Li Z, Li Q, Li X - J. Cell. Mol. Med. (2015)

(A) Massion staining. (a) PBS; (b) MSCs; (c) GENE; (d) MSCs+GENE. Bar plots of collagen volume fraction in respective groups (right). (B) Sirius red staining. (a) PBS; (b) MSCs; (c) GENE; (d) MSCs+GENE. Bar plots of collagen volume fraction in respective groups (right). Note that CVF was significantly reduced in MSCs and GENE groups and further reduced in MSCs+GENE group compared to PBS group. Bonferroni adjusted *P < 0.01 versus PSB; †P < 0.01 versus GENE; ‡P < 0.05 versus 8 weeks.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4549037&req=5

fig03: (A) Massion staining. (a) PBS; (b) MSCs; (c) GENE; (d) MSCs+GENE. Bar plots of collagen volume fraction in respective groups (right). (B) Sirius red staining. (a) PBS; (b) MSCs; (c) GENE; (d) MSCs+GENE. Bar plots of collagen volume fraction in respective groups (right). Note that CVF was significantly reduced in MSCs and GENE groups and further reduced in MSCs+GENE group compared to PBS group. Bonferroni adjusted *P < 0.01 versus PSB; †P < 0.01 versus GENE; ‡P < 0.05 versus 8 weeks.
Mentions: Collagen volume fraction was significantly reduced in MSCs and GENE group and further reduced in MSCs plus GENE group compared to PBS group at the end of study (Fig.3A: Massion staining and Fig.3B: Sirius red staining). von Willebrand factor staining showed a tendency for increased vWF expression in MSCs and GENE group and which was significantly up-regulated in MSCs+GENE group compared to PBS group (Fig.4).

Bottom Line: Cardiac function was improved in MSCs, GENE and MSCs+GENE groups.Collagen volume fraction was significantly reduced and myocardial TGF-β1 mRNA expression significantly down-regulated in both GENE and MSCs+GENE groups, collagen type I/III ratio reduction was more significant in MSCs+GENE group than in MSCs or GENE group.Myocardial MSCs and hVEGF165 plasmid injection improves cardiac function possibly through down-regulating myocardial TGF-β1 expression and reducing the type I/III collagen ratio in this DCM rat model.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.

No MeSH data available.


Related in: MedlinePlus