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High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss.

Zeng H, Vaka VR, He X, Booz GW, Chen JX - J. Cell. Mol. Med. (2015)

Bottom Line: SIRT3 is a mitochondrial protein associated with increased human life span and metabolism.HFD resulted in a significant reduction in SIRT3 expression in the heart.However, HFD did not further reduce capillary density in SIRT3 KO hearts, implicating SIRT3 loss in HFD-induced capillary rarefaction.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology and Toxicology, The University of Mississippi Medical Center, School of Medicine, Jackson, MS, USA.

No MeSH data available.


Related in: MedlinePlus

Assessment of cardiac function by echocardiography. (A) Representative M-mode tracings are shown. (B) Ejection fraction and (C) fractional shortening were determined. Values are means ± SEM, n = 10. PI = ns, PD and PS ≤ 0.01; *P ≤ 0.05; **P ≤ 0.01.
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fig05: Assessment of cardiac function by echocardiography. (A) Representative M-mode tracings are shown. (B) Ejection fraction and (C) fractional shortening were determined. Values are means ± SEM, n = 10. PI = ns, PD and PS ≤ 0.01; *P ≤ 0.05; **P ≤ 0.01.

Mentions: Mice fed a HFD exhibited a modest decline in cardiac function. As seen in Figure5, EF and FS were significantly decreased in WT mice fed HFD compared to mice fed ND for 16 weeks. Knocking out SIRT3 under ND also decreased cardiac function compared to WT mice fed ND. High-fat diet treatment further reduced cardiac performance in SIRT3 KO mice (Fig.5) to an extent that on average was greater than for WT mice; however, no interaction between HFD and SIRT3 loss was observed.


High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss.

Zeng H, Vaka VR, He X, Booz GW, Chen JX - J. Cell. Mol. Med. (2015)

Assessment of cardiac function by echocardiography. (A) Representative M-mode tracings are shown. (B) Ejection fraction and (C) fractional shortening were determined. Values are means ± SEM, n = 10. PI = ns, PD and PS ≤ 0.01; *P ≤ 0.05; **P ≤ 0.01.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4549035&req=5

fig05: Assessment of cardiac function by echocardiography. (A) Representative M-mode tracings are shown. (B) Ejection fraction and (C) fractional shortening were determined. Values are means ± SEM, n = 10. PI = ns, PD and PS ≤ 0.01; *P ≤ 0.05; **P ≤ 0.01.
Mentions: Mice fed a HFD exhibited a modest decline in cardiac function. As seen in Figure5, EF and FS were significantly decreased in WT mice fed HFD compared to mice fed ND for 16 weeks. Knocking out SIRT3 under ND also decreased cardiac function compared to WT mice fed ND. High-fat diet treatment further reduced cardiac performance in SIRT3 KO mice (Fig.5) to an extent that on average was greater than for WT mice; however, no interaction between HFD and SIRT3 loss was observed.

Bottom Line: SIRT3 is a mitochondrial protein associated with increased human life span and metabolism.HFD resulted in a significant reduction in SIRT3 expression in the heart.However, HFD did not further reduce capillary density in SIRT3 KO hearts, implicating SIRT3 loss in HFD-induced capillary rarefaction.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology and Toxicology, The University of Mississippi Medical Center, School of Medicine, Jackson, MS, USA.

No MeSH data available.


Related in: MedlinePlus