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Novel mechanism of cardiac protection by valsartan: synergetic roles of TGF-β1 and HIF-1α in Ang II-mediated fibrosis after myocardial infarction.

Sui X, Wei H, Wang D - J. Cell. Mol. Med. (2015)

Bottom Line: By blocking with valsartan, a blocker of Ang II type I (AT1) receptor, we confirmed that the up-regulation of TGF-β/Smad and Hif-1α was through the Ang II-mediated pathway.By administering TGF-β or dimethyloxalylglycine, we determined that both TGF-β/Smad and Hif-1α contributed to Ang II-mediated collagen accumulation and a synergetic effect between them was observed.Heart function, infarcted size, wall thickness as well as myocardial vascularization of ischaemic hearts were also significantly improved by valsartan compared with saline and hydralazine.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiothoracic Surgery, The Civil Aviation General Hospital, Chaoyang District, Beijing, China.

No MeSH data available.


Related in: MedlinePlus

The effects of saline and valsartan on cardiac function were evaluated by echocardiography and haemodynamics. Comparing the groups receiving injection of saline or hydralazine, echocardiography measurement showed that both LVEF and LVFS in rats receiving valsartan injection were significantly increased 4 weeks after surgery. Haemodynamics analysis demonstrated consistent results with that by echocardiography – that LVEDP significantly decreased and +dp/dtmax significantly increased in valsartan-treated rats compared to saline- and hydralazine-treated groups, indicating that treatment by valsartan exerted beneficial effects on heart function after MI (n = 10, *P < 0.05; **P < 0.01).
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fig05: The effects of saline and valsartan on cardiac function were evaluated by echocardiography and haemodynamics. Comparing the groups receiving injection of saline or hydralazine, echocardiography measurement showed that both LVEF and LVFS in rats receiving valsartan injection were significantly increased 4 weeks after surgery. Haemodynamics analysis demonstrated consistent results with that by echocardiography – that LVEDP significantly decreased and +dp/dtmax significantly increased in valsartan-treated rats compared to saline- and hydralazine-treated groups, indicating that treatment by valsartan exerted beneficial effects on heart function after MI (n = 10, *P < 0.05; **P < 0.01).

Mentions: Four weeks after surgery, echocardiography was performed to evaluate the effect of valsartan on cardiac function. The results demonstrated that both LVEF and LVFS were significantly improved in valsartan-treated animals compared to saline-treated ones (P < 0.01, Fig.5). The functional improvement by valsartan after MI was further confirmed by haemodynamic measurement, which revealed that the injection of valsartan markedly decreased LV end-diastolic pressure (LVEDP) compared to saline (P < 0.01). Meanwhile, the maximum LV change in pressure over time (+dp/dtmax) was significantly enhanced because of the injection of valsartan compared to the injection of saline (P < 0.05). Compared with saline treatment, hydralazine treatment did not result in significant improvement in cardiac function.


Novel mechanism of cardiac protection by valsartan: synergetic roles of TGF-β1 and HIF-1α in Ang II-mediated fibrosis after myocardial infarction.

Sui X, Wei H, Wang D - J. Cell. Mol. Med. (2015)

The effects of saline and valsartan on cardiac function were evaluated by echocardiography and haemodynamics. Comparing the groups receiving injection of saline or hydralazine, echocardiography measurement showed that both LVEF and LVFS in rats receiving valsartan injection were significantly increased 4 weeks after surgery. Haemodynamics analysis demonstrated consistent results with that by echocardiography – that LVEDP significantly decreased and +dp/dtmax significantly increased in valsartan-treated rats compared to saline- and hydralazine-treated groups, indicating that treatment by valsartan exerted beneficial effects on heart function after MI (n = 10, *P < 0.05; **P < 0.01).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4549028&req=5

fig05: The effects of saline and valsartan on cardiac function were evaluated by echocardiography and haemodynamics. Comparing the groups receiving injection of saline or hydralazine, echocardiography measurement showed that both LVEF and LVFS in rats receiving valsartan injection were significantly increased 4 weeks after surgery. Haemodynamics analysis demonstrated consistent results with that by echocardiography – that LVEDP significantly decreased and +dp/dtmax significantly increased in valsartan-treated rats compared to saline- and hydralazine-treated groups, indicating that treatment by valsartan exerted beneficial effects on heart function after MI (n = 10, *P < 0.05; **P < 0.01).
Mentions: Four weeks after surgery, echocardiography was performed to evaluate the effect of valsartan on cardiac function. The results demonstrated that both LVEF and LVFS were significantly improved in valsartan-treated animals compared to saline-treated ones (P < 0.01, Fig.5). The functional improvement by valsartan after MI was further confirmed by haemodynamic measurement, which revealed that the injection of valsartan markedly decreased LV end-diastolic pressure (LVEDP) compared to saline (P < 0.01). Meanwhile, the maximum LV change in pressure over time (+dp/dtmax) was significantly enhanced because of the injection of valsartan compared to the injection of saline (P < 0.05). Compared with saline treatment, hydralazine treatment did not result in significant improvement in cardiac function.

Bottom Line: By blocking with valsartan, a blocker of Ang II type I (AT1) receptor, we confirmed that the up-regulation of TGF-β/Smad and Hif-1α was through the Ang II-mediated pathway.By administering TGF-β or dimethyloxalylglycine, we determined that both TGF-β/Smad and Hif-1α contributed to Ang II-mediated collagen accumulation and a synergetic effect between them was observed.Heart function, infarcted size, wall thickness as well as myocardial vascularization of ischaemic hearts were also significantly improved by valsartan compared with saline and hydralazine.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiothoracic Surgery, The Civil Aviation General Hospital, Chaoyang District, Beijing, China.

No MeSH data available.


Related in: MedlinePlus