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Chicken egg yolk antibodies (IgY) as non-antibiotic production enhancers for use in swine production: a review.

Li X, Wang L, Zhen Y, Li S, Xu Y - J Anim Sci Biotechnol (2015)

Bottom Line: Chicken egg yolk antibodies (IgY) have attracted considerable attention as an alternative to antibiotics to maintain swine health and performance.Oral administration of IgY possesses many advantages over mammalian IgG such as cost-effectiveness, convenience and high yield.Some potential obstacles to the adoption of IgY technology are also discussed.

View Article: PubMed Central - PubMed

Affiliation: School of Life Science and Technology, Dalian University of Technology, Dalian, 116024 China ; Ministry of Education Center for Food Safety of Animal Origin, Dalian, 116620 China.

ABSTRACT
In recent years, the use of in-feed antibiotics for growth and disease prevention in livestock production has been under severe scrutiny. The use and misuse of in-feed antibiotics has led to problems with drug residues in animal products and increased bacterial resistance. Chicken egg yolk antibodies (IgY) have attracted considerable attention as an alternative to antibiotics to maintain swine health and performance. Oral administration of IgY possesses many advantages over mammalian IgG such as cost-effectiveness, convenience and high yield. This review presents an overview of the potential to use IgY immunotherapy for the prevention and treatment of swine diarrhea diseases and speculates on the future of IgY technology. Included are a review of the potential applications of IgY in the control of enteric infections of either bacterial or viral origin such as enterotoxigenic Escherichia coli, Salmonella spp., rotavirus, porcine transmissible gastroenteritis virus, and porcine epidemic diarrhea virus. Some potential obstacles to the adoption of IgY technology are also discussed.

No MeSH data available.


Related in: MedlinePlus

Possible primary mode of action by which IgY protects pigs against E coli K88 induced diarrhea. Modified from Hatta et al. [85]
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Fig1: Possible primary mode of action by which IgY protects pigs against E coli K88 induced diarrhea. Modified from Hatta et al. [85]

Mentions: The exact mechanisms through which IgY counteracts pathogen activity have not been determined. However, several mechanisms have been proposed by Xu et al. (2011) [14] including agglutination of bacteria, inhibition of adhesion, as well as opsonization followed by phagocytosis and toxin neutralization. Among these, inhibition of adhesion is considered the primary mechanism by which specific IgY functions. Briefly, IgY antibodies generated against intestinal disease causing organisms may reduce the incidence of disease by preventing the attachment of pathogens to the intestine, such as blocking the mucosal receptor, interfering with binding to mucins, or neutralizing the colonization factor (such as the outer membrane protein, lipopolysaccharide, fimbriae (or pili), and flagella) [26]. The possible primary mode of action by which IgY protects pigs against E coli K88 induced diarrhea is illustrated in Fig. 1.Fig. 1


Chicken egg yolk antibodies (IgY) as non-antibiotic production enhancers for use in swine production: a review.

Li X, Wang L, Zhen Y, Li S, Xu Y - J Anim Sci Biotechnol (2015)

Possible primary mode of action by which IgY protects pigs against E coli K88 induced diarrhea. Modified from Hatta et al. [85]
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4549021&req=5

Fig1: Possible primary mode of action by which IgY protects pigs against E coli K88 induced diarrhea. Modified from Hatta et al. [85]
Mentions: The exact mechanisms through which IgY counteracts pathogen activity have not been determined. However, several mechanisms have been proposed by Xu et al. (2011) [14] including agglutination of bacteria, inhibition of adhesion, as well as opsonization followed by phagocytosis and toxin neutralization. Among these, inhibition of adhesion is considered the primary mechanism by which specific IgY functions. Briefly, IgY antibodies generated against intestinal disease causing organisms may reduce the incidence of disease by preventing the attachment of pathogens to the intestine, such as blocking the mucosal receptor, interfering with binding to mucins, or neutralizing the colonization factor (such as the outer membrane protein, lipopolysaccharide, fimbriae (or pili), and flagella) [26]. The possible primary mode of action by which IgY protects pigs against E coli K88 induced diarrhea is illustrated in Fig. 1.Fig. 1

Bottom Line: Chicken egg yolk antibodies (IgY) have attracted considerable attention as an alternative to antibiotics to maintain swine health and performance.Oral administration of IgY possesses many advantages over mammalian IgG such as cost-effectiveness, convenience and high yield.Some potential obstacles to the adoption of IgY technology are also discussed.

View Article: PubMed Central - PubMed

Affiliation: School of Life Science and Technology, Dalian University of Technology, Dalian, 116024 China ; Ministry of Education Center for Food Safety of Animal Origin, Dalian, 116620 China.

ABSTRACT
In recent years, the use of in-feed antibiotics for growth and disease prevention in livestock production has been under severe scrutiny. The use and misuse of in-feed antibiotics has led to problems with drug residues in animal products and increased bacterial resistance. Chicken egg yolk antibodies (IgY) have attracted considerable attention as an alternative to antibiotics to maintain swine health and performance. Oral administration of IgY possesses many advantages over mammalian IgG such as cost-effectiveness, convenience and high yield. This review presents an overview of the potential to use IgY immunotherapy for the prevention and treatment of swine diarrhea diseases and speculates on the future of IgY technology. Included are a review of the potential applications of IgY in the control of enteric infections of either bacterial or viral origin such as enterotoxigenic Escherichia coli, Salmonella spp., rotavirus, porcine transmissible gastroenteritis virus, and porcine epidemic diarrhea virus. Some potential obstacles to the adoption of IgY technology are also discussed.

No MeSH data available.


Related in: MedlinePlus