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LDL in patients with subclinical hypothyroidism shows increased lipid peroxidation.

Zha K, Zuo C, Wang A, Zhang B, Zhang Y, Wang B, Wang Y, Zhao J, Gao L, Xu C - Lipids Health Dis (2015)

Bottom Line: The HODE and HETE concentrations clearly increased in the significant SCH patients compared with the euthyroid subjects, but there was no difference between the mild SCH and euthyroid groups.Among all subjects, linear and significant positive correlations were identified between TSH and mean-IMT after adjustment for confounding factors (r = 0.480, p = 0.018).HODEs in LDL were also positively associated with mean-IMT.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, 250021, China.

ABSTRACT

Background: Population-based studies have demonstrated that subclinical hypothyroidism (SCH) is an independent risk factor for atherosclerosis (OR = 1.9). However, this connection cannot be entirely explained by dyslipidemia accompanied by SCH. Lipid peroxidation also plays an important role in the development of atherosclerosis. In this study, we aimed to evaluate oxidative stress in SCH patients, as measured according to concentrations of hydroxy-octadecadienoic acids (HODEs) and hydroxy-eicosatetraenoic acids (HETEs) in both plasma and low density lipoproteins (LDL).

Subjects and methods: The concentrations of HODEs and HETEs in both LDL and plasma were examined in euthyroid (n = 10), mild SCH (4.5 ≤ TSH < 10 mU/L, n = 10), and significant SCH (TSH ≥ 10 mU/L, n = 10) subjects, using a liquid chromatograph-electrospray ionization- mass spectrometer. Then, we explored the relationship among LDL oxidation, TSH levels, and carotid intima-media thickness (IMT), a biomarker of subclinical atherosclerosis.

Results: Serum LDL-C levels and mean-IMT in the significant SCH group were higher than in the euthyroid group (p < 0.05). The HODE and HETE concentrations clearly increased in the significant SCH patients compared with the euthyroid subjects, but there was no difference between the mild SCH and euthyroid groups. Among all subjects, linear and significant positive correlations were identified between TSH and mean-IMT after adjustment for confounding factors (r = 0.480, p = 0.018). Both 9-HODE (r = 0.376, p = 0.041) and 13-HODE (r = 0.447, p = 0.013) in LDL were linearly and positively correlated with TSH. The concentrations of HODEs (both 9-HODE and 13-HODE) in LDL were much higher in the thickened IMT group than in the normal IMT group (p =  .017 and 0.015, respectively). HODEs in LDL were also positively associated with mean-IMT.

Conclusions: Our findings showed that lipid peroxidation was higher in the significant SCH patients than in the euthyroid subjects, which suggested that qualitative as well as quantitative changes in serum lipids resulting from SCH may add to atherosclerosis risk.

No MeSH data available.


Related in: MedlinePlus

Correlation analysis between TSH and mean-IMT in the study population. Partial correlation analysis after adjustment for age, gender, BMI, TC, HDL-C, LDL-C and TG: r = 0.480, p =0.018
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Fig1: Correlation analysis between TSH and mean-IMT in the study population. Partial correlation analysis after adjustment for age, gender, BMI, TC, HDL-C, LDL-C and TG: r = 0.480, p =0.018

Mentions: Carotid IMT is strongly associated with atherosclerosis. An IMT greater than 0.9 mm is almost certainly indicative of atherosclerosis and increased risk of cardiovascular disease [14]. Notably, among all subjects, linear and significant positive correlations were identified between TSH and mean-IMT (r = 0.401, p = 0.028). Interestingly, the correlations remained significant even after we adjusted for age, gender, BMI, TC, HDL-C,LDL-C, and TG (r = 0.480, p = 0.018) (Fig. 1). This finding suggests an association between SCH and the risk for atherosclerosis.Fig. 1


LDL in patients with subclinical hypothyroidism shows increased lipid peroxidation.

Zha K, Zuo C, Wang A, Zhang B, Zhang Y, Wang B, Wang Y, Zhao J, Gao L, Xu C - Lipids Health Dis (2015)

Correlation analysis between TSH and mean-IMT in the study population. Partial correlation analysis after adjustment for age, gender, BMI, TC, HDL-C, LDL-C and TG: r = 0.480, p =0.018
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4548906&req=5

Fig1: Correlation analysis between TSH and mean-IMT in the study population. Partial correlation analysis after adjustment for age, gender, BMI, TC, HDL-C, LDL-C and TG: r = 0.480, p =0.018
Mentions: Carotid IMT is strongly associated with atherosclerosis. An IMT greater than 0.9 mm is almost certainly indicative of atherosclerosis and increased risk of cardiovascular disease [14]. Notably, among all subjects, linear and significant positive correlations were identified between TSH and mean-IMT (r = 0.401, p = 0.028). Interestingly, the correlations remained significant even after we adjusted for age, gender, BMI, TC, HDL-C,LDL-C, and TG (r = 0.480, p = 0.018) (Fig. 1). This finding suggests an association between SCH and the risk for atherosclerosis.Fig. 1

Bottom Line: The HODE and HETE concentrations clearly increased in the significant SCH patients compared with the euthyroid subjects, but there was no difference between the mild SCH and euthyroid groups.Among all subjects, linear and significant positive correlations were identified between TSH and mean-IMT after adjustment for confounding factors (r = 0.480, p = 0.018).HODEs in LDL were also positively associated with mean-IMT.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, 250021, China.

ABSTRACT

Background: Population-based studies have demonstrated that subclinical hypothyroidism (SCH) is an independent risk factor for atherosclerosis (OR = 1.9). However, this connection cannot be entirely explained by dyslipidemia accompanied by SCH. Lipid peroxidation also plays an important role in the development of atherosclerosis. In this study, we aimed to evaluate oxidative stress in SCH patients, as measured according to concentrations of hydroxy-octadecadienoic acids (HODEs) and hydroxy-eicosatetraenoic acids (HETEs) in both plasma and low density lipoproteins (LDL).

Subjects and methods: The concentrations of HODEs and HETEs in both LDL and plasma were examined in euthyroid (n = 10), mild SCH (4.5 ≤ TSH < 10 mU/L, n = 10), and significant SCH (TSH ≥ 10 mU/L, n = 10) subjects, using a liquid chromatograph-electrospray ionization- mass spectrometer. Then, we explored the relationship among LDL oxidation, TSH levels, and carotid intima-media thickness (IMT), a biomarker of subclinical atherosclerosis.

Results: Serum LDL-C levels and mean-IMT in the significant SCH group were higher than in the euthyroid group (p < 0.05). The HODE and HETE concentrations clearly increased in the significant SCH patients compared with the euthyroid subjects, but there was no difference between the mild SCH and euthyroid groups. Among all subjects, linear and significant positive correlations were identified between TSH and mean-IMT after adjustment for confounding factors (r = 0.480, p = 0.018). Both 9-HODE (r = 0.376, p = 0.041) and 13-HODE (r = 0.447, p = 0.013) in LDL were linearly and positively correlated with TSH. The concentrations of HODEs (both 9-HODE and 13-HODE) in LDL were much higher in the thickened IMT group than in the normal IMT group (p =  .017 and 0.015, respectively). HODEs in LDL were also positively associated with mean-IMT.

Conclusions: Our findings showed that lipid peroxidation was higher in the significant SCH patients than in the euthyroid subjects, which suggested that qualitative as well as quantitative changes in serum lipids resulting from SCH may add to atherosclerosis risk.

No MeSH data available.


Related in: MedlinePlus