Limits...
Assessing the prevalence of autoimmune, endocrine, gynecologic, and psychiatric comorbidities in an ethnically diverse cohort of female fibromyalgia patients: does the time from hysterectomy provide a clue?

Brooks L, Hadi J, Amber KT, Weiner M, La Riche CL, Ference T - J Pain Res (2015)

Bottom Line: Logistic regression modeling found that gynecologic, endocrine, and autoimmune diagnoses were independently associated with a diagnosis of FM.A similar pattern was not found in the control group.This study demonstrates that autoimmune, endocrine, and gynecologic pathologies occur more commonly in women with FM than in those with CP, which is consistent with findings in less ethnically diverse samples.

View Article: PubMed Central - PubMed

Affiliation: Department of Rehabilitation Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.

ABSTRACT

Background: This retrospective chart review investigated differences in the prevalence of medical comorbidity between women with fibromyalgia (FM) (n=219) and a control group women with chronic pain (CP) without FM (n=116). The specific aims were to compare the prevalence of autoimmune, psychiatric, endocrine, gynecologic pathology, the relationship between timing of gynecologic surgery, and pain onset. We additionally sought to compare the number of comorbidities in an ethnically diverse cohort.

Methods: This was a retrospective chart review of patients seen in FM or CP clinics at an academic medical center in 2009-2010.

Results: Logistic regression modeling found that gynecologic, endocrine, and autoimmune diagnoses were independently associated with a diagnosis of FM. Detailed analyses showed that thyroid disease (P<0.01) and gynecologic surgery (P<0.05) were significantly more common in FM. Women with FM were more likely to have multiple autoimmune, endocrine, gynecologic, or psychiatric pathologies. A relationship was observed between the timing of gynecologic surgery and pain onset in FM, with more surgeries observed in the years just prior to pain onset or in the year after pain onset. A similar pattern was not found in the control group.

Conclusion: This study demonstrates that autoimmune, endocrine, and gynecologic pathologies occur more commonly in women with FM than in those with CP, which is consistent with findings in less ethnically diverse samples. Moreover, a relationship was found between timing of pain onset and gynecologic surgery. A larger prospective study of the relationship between gynecologic surgery and pain onset in FM is warranted.

No MeSH data available.


Related in: MedlinePlus

Hysterectomy/oophorectomy and pain onset in fibromyalgia (n=68).
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4548754&req=5

f1-jpr-8-561: Hysterectomy/oophorectomy and pain onset in fibromyalgia (n=68).

Mentions: In terms of surgical history, hysterectomy + oophorectomy, hysterectomy + oophorectomy + cystectomy, and total gynecologic surgeries occurred more frequently in the FM group. Across all participants with a history of hysterectomy or oophorectomy, the procedure preceded pain onset in 73.1% of cases. On average, surgery occurred 8.3 (12.8) years before pain onset. The range was from surgery occurring 43 years before pain onset to surgery occurring 19 years after pain onset. When the distributions between FM and CP groups are displayed, there is a noticeable difference in the shape of the distributions (Figures 1 and 2). Of note, 25 and 12 patients were excluded from the FM group and control group, respectively, as the time of hysterectomy was not available in the medical records.


Assessing the prevalence of autoimmune, endocrine, gynecologic, and psychiatric comorbidities in an ethnically diverse cohort of female fibromyalgia patients: does the time from hysterectomy provide a clue?

Brooks L, Hadi J, Amber KT, Weiner M, La Riche CL, Ference T - J Pain Res (2015)

Hysterectomy/oophorectomy and pain onset in fibromyalgia (n=68).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4548754&req=5

f1-jpr-8-561: Hysterectomy/oophorectomy and pain onset in fibromyalgia (n=68).
Mentions: In terms of surgical history, hysterectomy + oophorectomy, hysterectomy + oophorectomy + cystectomy, and total gynecologic surgeries occurred more frequently in the FM group. Across all participants with a history of hysterectomy or oophorectomy, the procedure preceded pain onset in 73.1% of cases. On average, surgery occurred 8.3 (12.8) years before pain onset. The range was from surgery occurring 43 years before pain onset to surgery occurring 19 years after pain onset. When the distributions between FM and CP groups are displayed, there is a noticeable difference in the shape of the distributions (Figures 1 and 2). Of note, 25 and 12 patients were excluded from the FM group and control group, respectively, as the time of hysterectomy was not available in the medical records.

Bottom Line: Logistic regression modeling found that gynecologic, endocrine, and autoimmune diagnoses were independently associated with a diagnosis of FM.A similar pattern was not found in the control group.This study demonstrates that autoimmune, endocrine, and gynecologic pathologies occur more commonly in women with FM than in those with CP, which is consistent with findings in less ethnically diverse samples.

View Article: PubMed Central - PubMed

Affiliation: Department of Rehabilitation Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.

ABSTRACT

Background: This retrospective chart review investigated differences in the prevalence of medical comorbidity between women with fibromyalgia (FM) (n=219) and a control group women with chronic pain (CP) without FM (n=116). The specific aims were to compare the prevalence of autoimmune, psychiatric, endocrine, gynecologic pathology, the relationship between timing of gynecologic surgery, and pain onset. We additionally sought to compare the number of comorbidities in an ethnically diverse cohort.

Methods: This was a retrospective chart review of patients seen in FM or CP clinics at an academic medical center in 2009-2010.

Results: Logistic regression modeling found that gynecologic, endocrine, and autoimmune diagnoses were independently associated with a diagnosis of FM. Detailed analyses showed that thyroid disease (P<0.01) and gynecologic surgery (P<0.05) were significantly more common in FM. Women with FM were more likely to have multiple autoimmune, endocrine, gynecologic, or psychiatric pathologies. A relationship was observed between the timing of gynecologic surgery and pain onset in FM, with more surgeries observed in the years just prior to pain onset or in the year after pain onset. A similar pattern was not found in the control group.

Conclusion: This study demonstrates that autoimmune, endocrine, and gynecologic pathologies occur more commonly in women with FM than in those with CP, which is consistent with findings in less ethnically diverse samples. Moreover, a relationship was found between timing of pain onset and gynecologic surgery. A larger prospective study of the relationship between gynecologic surgery and pain onset in FM is warranted.

No MeSH data available.


Related in: MedlinePlus