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Hormonal determinants of the severity of andropausal and depressive symptoms in middle-aged and elderly men with prediabetes.

Rabijewski M, Papierska L, Kuczerowski R, Piątkiewicz P - Clin Interv Aging (2015)

Bottom Line: The higher prevalence of andropausal symptoms was independently associated with cFT and IGF-1 in middle-aged men and with TT and DHEAS in elderly men with PD.The more severe depression symptoms were associated with low TT and DHEAS in middle-aged men and with low cFT and DHEAS in elderly men with PD.In conclusion, the prevalence of andropausal symptoms, especially psychological, was higher in prediabetic patients as compared to healthy men, while the severity of depressive symptoms was higher only in middle-aged men with PD.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Diseases, Diabetology and Endocrinology, Medical University of Warsaw, Poland.

ABSTRACT
Andropausal and depressive symptoms are common in aging males and may be associated with hormone deficiency. We investigated the severity of andropausal and depressive symptoms, as well as their hormonal determinants, in 196 middle-aged and elderly men (age range: 40-80 years) with prediabetes (PD) and in 184 healthy peers. PD was diagnosed according to the definition of the American Diabetes Association. The severity of andropausal and depressive symptoms was assessed using the Aging Males' Symptoms Rating Scale and the Self-Rating Depression Scale. Total testosterone (TT), calculated free testosterone (cFT), dehydroepiandrosterone sulfate (DHEAS), and insulin-like growth factor 1 (IGF-1) were measured. The prevalence of andropausal syndrome in men with PD was significantly higher than that in healthy men (35% vs 11%, respectively). In men with PD aged 40-59 years, the severity of sexual, psychological, and all andropausal symptoms was greater than in healthy peers, while in elderly men (60-80 years), only the severity of psychological symptoms was greater than in healthy peers. The severity of depressive symptoms in the middle-aged men with PD was greater than in healthy peers, while the severity of depressive symptoms in elderly men with PD and healthy peers was similar. The higher prevalence of andropausal symptoms was independently associated with cFT and IGF-1 in middle-aged men and with TT and DHEAS in elderly men with PD. The more severe depression symptoms were associated with low TT and DHEAS in middle-aged men and with low cFT and DHEAS in elderly men with PD. In conclusion, the prevalence of andropausal symptoms, especially psychological, was higher in prediabetic patients as compared to healthy men, while the severity of depressive symptoms was higher only in middle-aged men with PD. Hormonal determinants of andropausal and depressive symptoms are different in middle-aged and elderly patients, but endocrine tests are necessary in all men with PD.

No MeSH data available.


Related in: MedlinePlus

Prevalence (%) of andropausal syndrome in men with prediabetes (n=196) and healthy men (n=184).Notes: Andropausal syndrome was diagnosed according to the AMS18 and was diagnosed if the total AMS score was 50 points or higher. The intergroup differences were tested using the χ2 test.Abbreviations: AMS, Aging Males’ Symptoms rating scale; PD, prediabetes.
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f1-cia-10-1381: Prevalence (%) of andropausal syndrome in men with prediabetes (n=196) and healthy men (n=184).Notes: Andropausal syndrome was diagnosed according to the AMS18 and was diagnosed if the total AMS score was 50 points or higher. The intergroup differences were tested using the χ2 test.Abbreviations: AMS, Aging Males’ Symptoms rating scale; PD, prediabetes.

Mentions: The prevalence of AS in men with PD was significantly higher than in healthy men (35% vs 11%, respectively; P<0.001). Analysis of investigated men after dividing by the age revealed that the prevalence of AS in patients with PD aged 40–59 years was higher compared with that in healthy peers (29% vs 9%, respectively; P<0.001) and that the prevalence of AS in men with PD aged 60–80 years was statistically significantly higher than that observed in healthy peers (43% vs 36%, respectively; P<0.05) (Figure 1). Among men with PD, the prevalence of AS was significantly higher in subjects aged from 60 years to 80 years when compared with those aged from 40 years to 59 years (43% vs 29%, respectively; P<0.001) (Table 1).


Hormonal determinants of the severity of andropausal and depressive symptoms in middle-aged and elderly men with prediabetes.

Rabijewski M, Papierska L, Kuczerowski R, Piątkiewicz P - Clin Interv Aging (2015)

Prevalence (%) of andropausal syndrome in men with prediabetes (n=196) and healthy men (n=184).Notes: Andropausal syndrome was diagnosed according to the AMS18 and was diagnosed if the total AMS score was 50 points or higher. The intergroup differences were tested using the χ2 test.Abbreviations: AMS, Aging Males’ Symptoms rating scale; PD, prediabetes.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4548738&req=5

f1-cia-10-1381: Prevalence (%) of andropausal syndrome in men with prediabetes (n=196) and healthy men (n=184).Notes: Andropausal syndrome was diagnosed according to the AMS18 and was diagnosed if the total AMS score was 50 points or higher. The intergroup differences were tested using the χ2 test.Abbreviations: AMS, Aging Males’ Symptoms rating scale; PD, prediabetes.
Mentions: The prevalence of AS in men with PD was significantly higher than in healthy men (35% vs 11%, respectively; P<0.001). Analysis of investigated men after dividing by the age revealed that the prevalence of AS in patients with PD aged 40–59 years was higher compared with that in healthy peers (29% vs 9%, respectively; P<0.001) and that the prevalence of AS in men with PD aged 60–80 years was statistically significantly higher than that observed in healthy peers (43% vs 36%, respectively; P<0.05) (Figure 1). Among men with PD, the prevalence of AS was significantly higher in subjects aged from 60 years to 80 years when compared with those aged from 40 years to 59 years (43% vs 29%, respectively; P<0.001) (Table 1).

Bottom Line: The higher prevalence of andropausal symptoms was independently associated with cFT and IGF-1 in middle-aged men and with TT and DHEAS in elderly men with PD.The more severe depression symptoms were associated with low TT and DHEAS in middle-aged men and with low cFT and DHEAS in elderly men with PD.In conclusion, the prevalence of andropausal symptoms, especially psychological, was higher in prediabetic patients as compared to healthy men, while the severity of depressive symptoms was higher only in middle-aged men with PD.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Diseases, Diabetology and Endocrinology, Medical University of Warsaw, Poland.

ABSTRACT
Andropausal and depressive symptoms are common in aging males and may be associated with hormone deficiency. We investigated the severity of andropausal and depressive symptoms, as well as their hormonal determinants, in 196 middle-aged and elderly men (age range: 40-80 years) with prediabetes (PD) and in 184 healthy peers. PD was diagnosed according to the definition of the American Diabetes Association. The severity of andropausal and depressive symptoms was assessed using the Aging Males' Symptoms Rating Scale and the Self-Rating Depression Scale. Total testosterone (TT), calculated free testosterone (cFT), dehydroepiandrosterone sulfate (DHEAS), and insulin-like growth factor 1 (IGF-1) were measured. The prevalence of andropausal syndrome in men with PD was significantly higher than that in healthy men (35% vs 11%, respectively). In men with PD aged 40-59 years, the severity of sexual, psychological, and all andropausal symptoms was greater than in healthy peers, while in elderly men (60-80 years), only the severity of psychological symptoms was greater than in healthy peers. The severity of depressive symptoms in the middle-aged men with PD was greater than in healthy peers, while the severity of depressive symptoms in elderly men with PD and healthy peers was similar. The higher prevalence of andropausal symptoms was independently associated with cFT and IGF-1 in middle-aged men and with TT and DHEAS in elderly men with PD. The more severe depression symptoms were associated with low TT and DHEAS in middle-aged men and with low cFT and DHEAS in elderly men with PD. In conclusion, the prevalence of andropausal symptoms, especially psychological, was higher in prediabetic patients as compared to healthy men, while the severity of depressive symptoms was higher only in middle-aged men with PD. Hormonal determinants of andropausal and depressive symptoms are different in middle-aged and elderly patients, but endocrine tests are necessary in all men with PD.

No MeSH data available.


Related in: MedlinePlus