Limits...
Transformation of benign fibroadenoma to malignant phyllodes tumor.

Sanders LM, Daigle ME, Tortora M, Panasiti R - Acta Radiol Open (2015)

Bottom Line: The transformation of a benign fibroadenoma into a phyllodes tumor is uncommon and unpredictable.We present ultrasound and magnetic resonance images, as well as pathology slides from core biopsy and surgical excision, to illustrate this transformation.However, in this case, pathology supports correct initial diagnosis of fibroadenoma and demonstrates a portion of the original fibroadenoma along the periphery of the malignant phyllodes tumor.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Breast Center, Barnabas Health Care Systems, Livingston, NJ, USA.

ABSTRACT
The transformation of a benign fibroadenoma into a phyllodes tumor is uncommon and unpredictable. We report the case of a 40-year-old woman with a core biopsy proven fibroadenoma that underwent transformation into a malignant phyllodes tumor after 3 years of size stability. We present ultrasound and magnetic resonance images, as well as pathology slides from core biopsy and surgical excision, to illustrate this transformation. It has been suggested that phyllodes tumors may be misdiagnosed as fibroadenomas by core biopsy. However, in this case, pathology supports correct initial diagnosis of fibroadenoma and demonstrates a portion of the original fibroadenoma along the periphery of the malignant phyllodes tumor.

No MeSH data available.


Related in: MedlinePlus

(a) Benign fibroadenoma with characteristic collagenous stroma and distorted, slit-like elongated ducts (10×, H&E). (b) Malignant phyllodes tumor with classic leaf-like epithelial proliferation and increased stromal cellularity (4×, H&E). (c) On higher power, the malignant phyllodes tumor shows marked stromal pleomorphism and increased mitotic activity (20×, H&E). (d) At the periphery of the malignant phyllodes tumor, a portion of the original fibroadenoma is identified (4×, H&E).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License 1 - License 2 - License 3
getmorefigures.php?uid=PMC4548734&req=5

fig2-2058460115592061: (a) Benign fibroadenoma with characteristic collagenous stroma and distorted, slit-like elongated ducts (10×, H&E). (b) Malignant phyllodes tumor with classic leaf-like epithelial proliferation and increased stromal cellularity (4×, H&E). (c) On higher power, the malignant phyllodes tumor shows marked stromal pleomorphism and increased mitotic activity (20×, H&E). (d) At the periphery of the malignant phyllodes tumor, a portion of the original fibroadenoma is identified (4×, H&E).

Mentions: It has been suggested that PTs may be misdiagnosed as FAs by core biopsy. However, in this case, pathology supports correct initial diagnosis of FA (Fig. 2a). In addition, pathology of the excised lesion (Fig 2b and c) demonstrates a portion of the original FA along the periphery of the malignant PT (Fig. 2d).Fig. 2.


Transformation of benign fibroadenoma to malignant phyllodes tumor.

Sanders LM, Daigle ME, Tortora M, Panasiti R - Acta Radiol Open (2015)

(a) Benign fibroadenoma with characteristic collagenous stroma and distorted, slit-like elongated ducts (10×, H&E). (b) Malignant phyllodes tumor with classic leaf-like epithelial proliferation and increased stromal cellularity (4×, H&E). (c) On higher power, the malignant phyllodes tumor shows marked stromal pleomorphism and increased mitotic activity (20×, H&E). (d) At the periphery of the malignant phyllodes tumor, a portion of the original fibroadenoma is identified (4×, H&E).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License 1 - License 2 - License 3
Show All Figures
getmorefigures.php?uid=PMC4548734&req=5

fig2-2058460115592061: (a) Benign fibroadenoma with characteristic collagenous stroma and distorted, slit-like elongated ducts (10×, H&E). (b) Malignant phyllodes tumor with classic leaf-like epithelial proliferation and increased stromal cellularity (4×, H&E). (c) On higher power, the malignant phyllodes tumor shows marked stromal pleomorphism and increased mitotic activity (20×, H&E). (d) At the periphery of the malignant phyllodes tumor, a portion of the original fibroadenoma is identified (4×, H&E).
Mentions: It has been suggested that PTs may be misdiagnosed as FAs by core biopsy. However, in this case, pathology supports correct initial diagnosis of FA (Fig. 2a). In addition, pathology of the excised lesion (Fig 2b and c) demonstrates a portion of the original FA along the periphery of the malignant PT (Fig. 2d).Fig. 2.

Bottom Line: The transformation of a benign fibroadenoma into a phyllodes tumor is uncommon and unpredictable.We present ultrasound and magnetic resonance images, as well as pathology slides from core biopsy and surgical excision, to illustrate this transformation.However, in this case, pathology supports correct initial diagnosis of fibroadenoma and demonstrates a portion of the original fibroadenoma along the periphery of the malignant phyllodes tumor.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Breast Center, Barnabas Health Care Systems, Livingston, NJ, USA.

ABSTRACT
The transformation of a benign fibroadenoma into a phyllodes tumor is uncommon and unpredictable. We report the case of a 40-year-old woman with a core biopsy proven fibroadenoma that underwent transformation into a malignant phyllodes tumor after 3 years of size stability. We present ultrasound and magnetic resonance images, as well as pathology slides from core biopsy and surgical excision, to illustrate this transformation. It has been suggested that phyllodes tumors may be misdiagnosed as fibroadenomas by core biopsy. However, in this case, pathology supports correct initial diagnosis of fibroadenoma and demonstrates a portion of the original fibroadenoma along the periphery of the malignant phyllodes tumor.

No MeSH data available.


Related in: MedlinePlus