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Association of brachial-ankle pulse wave velocity with atherosclerosis and presence of coronary artery disease in older patients.

Chung CM, Tseng YH, Lin YS, Hsu JT, Wang PC - Clin Interv Aging (2015)

Bottom Line: In addition to diabetes mellitus and body mass index, baPWV was one of the statistically meaningful predictors of significant CAD (diameter of stenosis >50%) in a multivariate analysis.When the extent of CAD was classified as nonsignificant or significant CAD (ie, one-, two-, and three-vessel disease), there was a significant difference in baPWV between the significant and nonsignificant CAD groups, but not between the three significant CAD groups.Multivariate linear regression analyses showed that the number of diseased vessels and baPWV were both significantly associated with the SYNTAX (SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery) score.

View Article: PubMed Central - PubMed

Affiliation: School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan County, Taiwan ; Chang Gung University of Science and Technology, Chiayi County, Taiwan.

ABSTRACT

Objective: Brachial-ankle pulse wave velocity (baPWV) is a simple and reproducible measure of arterial stiffness and is extensively used to assess risk of cardiovascular disease in Asia. We examined whether baPWV was associated with coronary atherosclerosis and presence and extent of coronary artery disease (CAD) in older patients with chest pain.

Methods: This cross-sectional study enrolled 370 consecutive patients >65 years old who underwent baPWV measurement and elective coronary angiogram for suspected CAD at a single cardiovascular center, between June 2013 and July 2014.

Results: In addition to diabetes mellitus and body mass index, baPWV was one of the statistically meaningful predictors of significant CAD (diameter of stenosis >50%) in a multivariate analysis. When the extent of CAD was classified as nonsignificant or significant CAD (ie, one-, two-, and three-vessel disease), there was a significant difference in baPWV between the significant and nonsignificant CAD groups, but not between the three significant CAD groups. Multivariate linear regression analyses showed that the number of diseased vessels and baPWV were both significantly associated with the SYNTAX (SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery) score. The cutoff value of baPWV at 1,874 cm/s had a sensitivity of 60.1%, specificity of 70.8%, and area under receiver operating characteristic curve of 0.639 in predicting CAD.

Conclusion: Arterial stiffness determined by baPWV was associated independently with CAD severity, as assessed by angiography and the SYNTAX score in older patients with chest pain. As a result, increased arterial stiffness assessed by baPWV is associated with the severity and presence of CAD in older patients.

No MeSH data available.


Related in: MedlinePlus

ROC curve between baPWV and the presence/absence of coronary artery disease.Note: Area under ROC curve of 0.639 predicts coronary artery stenosis.Abbreviations: baPWV, brachial-ankle pulse wave velocity; ROC, receiver operating characteristic.
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f3-cia-10-1369: ROC curve between baPWV and the presence/absence of coronary artery disease.Note: Area under ROC curve of 0.639 predicts coronary artery stenosis.Abbreviations: baPWV, brachial-ankle pulse wave velocity; ROC, receiver operating characteristic.

Mentions: We used ROC curve analysis to evaluate the association between baPWV and CAD and showed a trend toward a positive association between the extent of CAD and baPWV (Figure 3). Using the ROC curve, we determined the optimal cutoff value of baPWV and CAD that could predict the presence of coronary stenosis (Figure 3). The cutoff value of baPWV at 1,874 cm/s had a sensitivity of 60.1%, specificity of 70.8%, and area under ROC curve of 0.639 in predicting coronary artery stenosis.


Association of brachial-ankle pulse wave velocity with atherosclerosis and presence of coronary artery disease in older patients.

Chung CM, Tseng YH, Lin YS, Hsu JT, Wang PC - Clin Interv Aging (2015)

ROC curve between baPWV and the presence/absence of coronary artery disease.Note: Area under ROC curve of 0.639 predicts coronary artery stenosis.Abbreviations: baPWV, brachial-ankle pulse wave velocity; ROC, receiver operating characteristic.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4548723&req=5

f3-cia-10-1369: ROC curve between baPWV and the presence/absence of coronary artery disease.Note: Area under ROC curve of 0.639 predicts coronary artery stenosis.Abbreviations: baPWV, brachial-ankle pulse wave velocity; ROC, receiver operating characteristic.
Mentions: We used ROC curve analysis to evaluate the association between baPWV and CAD and showed a trend toward a positive association between the extent of CAD and baPWV (Figure 3). Using the ROC curve, we determined the optimal cutoff value of baPWV and CAD that could predict the presence of coronary stenosis (Figure 3). The cutoff value of baPWV at 1,874 cm/s had a sensitivity of 60.1%, specificity of 70.8%, and area under ROC curve of 0.639 in predicting coronary artery stenosis.

Bottom Line: In addition to diabetes mellitus and body mass index, baPWV was one of the statistically meaningful predictors of significant CAD (diameter of stenosis >50%) in a multivariate analysis.When the extent of CAD was classified as nonsignificant or significant CAD (ie, one-, two-, and three-vessel disease), there was a significant difference in baPWV between the significant and nonsignificant CAD groups, but not between the three significant CAD groups.Multivariate linear regression analyses showed that the number of diseased vessels and baPWV were both significantly associated with the SYNTAX (SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery) score.

View Article: PubMed Central - PubMed

Affiliation: School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan County, Taiwan ; Chang Gung University of Science and Technology, Chiayi County, Taiwan.

ABSTRACT

Objective: Brachial-ankle pulse wave velocity (baPWV) is a simple and reproducible measure of arterial stiffness and is extensively used to assess risk of cardiovascular disease in Asia. We examined whether baPWV was associated with coronary atherosclerosis and presence and extent of coronary artery disease (CAD) in older patients with chest pain.

Methods: This cross-sectional study enrolled 370 consecutive patients >65 years old who underwent baPWV measurement and elective coronary angiogram for suspected CAD at a single cardiovascular center, between June 2013 and July 2014.

Results: In addition to diabetes mellitus and body mass index, baPWV was one of the statistically meaningful predictors of significant CAD (diameter of stenosis >50%) in a multivariate analysis. When the extent of CAD was classified as nonsignificant or significant CAD (ie, one-, two-, and three-vessel disease), there was a significant difference in baPWV between the significant and nonsignificant CAD groups, but not between the three significant CAD groups. Multivariate linear regression analyses showed that the number of diseased vessels and baPWV were both significantly associated with the SYNTAX (SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery) score. The cutoff value of baPWV at 1,874 cm/s had a sensitivity of 60.1%, specificity of 70.8%, and area under receiver operating characteristic curve of 0.639 in predicting CAD.

Conclusion: Arterial stiffness determined by baPWV was associated independently with CAD severity, as assessed by angiography and the SYNTAX score in older patients with chest pain. As a result, increased arterial stiffness assessed by baPWV is associated with the severity and presence of CAD in older patients.

No MeSH data available.


Related in: MedlinePlus