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The relationship between fasting plasma glucose and MPO in patients with acute coronary syndrome.

Zhang X, Dong L, Wang Q, Xie X - BMC Cardiovasc Disord (2015)

Bottom Line: The results demonstrated that the levels of FPG were significantly and positively correlated with plasma MPO levels, Gensini scores, high sensitive C reaction protein(hs-CRP)levels, leukocyte and neutrophils count.The plasma MPO levels in the group C [68.68(52.62-91.88) U/L] were significantly higher than in the group A [63.04(26.18-97.75) U/L] and group B [58.22(23.95-89.54) U/L].This study demonstrates that FPG values are positively correlated with plasma MPO levels, suggesting MPO may play a role in the proatherogenesis of high FPG.

View Article: PubMed Central - PubMed

Affiliation: Department of Geriatrics, Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, P. R. China. xiangyuzhang2001@yahoo.com.cn.

ABSTRACT

Background: Inflammation plays a critical role in the progression of atherosclerosis, and hyperglycemia is a common feature in patients with ACS. We investigated the relationship between fasting plasma glucose (FPG) levels and the levels of the inflammatory factor, myeloperoxidase (MPO), in patients with acute coronary syndrome (ACS).

Method: A total of 85 patients with no prior history of diabetes mellitus were recruited. The patients were divided into three groups based on their FPG levels as follows: group A, FPG < 5.6 mmol/l; group B, 5.6 mmol/l ≤ FPG < 6.1 mmol/l; and group C, FPG ≥ 6.1 mmol/l. The FPG concentrations and plasma MPO levels were determined, coronary angioplasty was performed, and the Gensini scores were used to evaluate the severity of the coronary lesion. The MPO expression in peripheral blood mononuclear cells (PBMCs) in patients with ACS was determined using western blot analysis.

Result: The results demonstrated that the levels of FPG were significantly and positively correlated with plasma MPO levels, Gensini scores, high sensitive C reaction protein(hs-CRP)levels, leukocyte and neutrophils count. In multivariate regression analyses the FPG levels were positively correlated with plasma MPO levels, Gensini score and hs-CRP. The plasma MPO levels in the group C [68.68(52.62-91.88) U/L] were significantly higher than in the group A [63.04(26.18-97.75) U/L] and group B [58.22(23.95-89.54) U/L]. The plasma hs-CRP concentrations are also higher in group C [42.28 (0.31-169.40) mg/L] than in the group A [12.51(0.28-176.25) mg/L] and group B [14.7 (0.14-89.68) mg/L].

Conclusion: This study demonstrates that FPG values are positively correlated with plasma MPO levels, suggesting MPO may play a role in the proatherogenesis of high FPG.

No MeSH data available.


Related in: MedlinePlus

The MPO expression of PBMCs in the three groups. a Detection of MPO expression in cultured PBMCs from patients with ACS by Western blot analysis; b Effect of FPG on MPO expression of PBMCs, MPO expression is expressed as absorbance ratio of MPO product to β-actin product
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Fig3: The MPO expression of PBMCs in the three groups. a Detection of MPO expression in cultured PBMCs from patients with ACS by Western blot analysis; b Effect of FPG on MPO expression of PBMCs, MPO expression is expressed as absorbance ratio of MPO product to β-actin product

Mentions: MPO expression in PBMCs was detected by western blot analysis. As shown in Fig. 3, it was found that FPG had no effect on MPO expression in PBMCs from patients with ACS.


The relationship between fasting plasma glucose and MPO in patients with acute coronary syndrome.

Zhang X, Dong L, Wang Q, Xie X - BMC Cardiovasc Disord (2015)

The MPO expression of PBMCs in the three groups. a Detection of MPO expression in cultured PBMCs from patients with ACS by Western blot analysis; b Effect of FPG on MPO expression of PBMCs, MPO expression is expressed as absorbance ratio of MPO product to β-actin product
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4548711&req=5

Fig3: The MPO expression of PBMCs in the three groups. a Detection of MPO expression in cultured PBMCs from patients with ACS by Western blot analysis; b Effect of FPG on MPO expression of PBMCs, MPO expression is expressed as absorbance ratio of MPO product to β-actin product
Mentions: MPO expression in PBMCs was detected by western blot analysis. As shown in Fig. 3, it was found that FPG had no effect on MPO expression in PBMCs from patients with ACS.

Bottom Line: The results demonstrated that the levels of FPG were significantly and positively correlated with plasma MPO levels, Gensini scores, high sensitive C reaction protein(hs-CRP)levels, leukocyte and neutrophils count.The plasma MPO levels in the group C [68.68(52.62-91.88) U/L] were significantly higher than in the group A [63.04(26.18-97.75) U/L] and group B [58.22(23.95-89.54) U/L].This study demonstrates that FPG values are positively correlated with plasma MPO levels, suggesting MPO may play a role in the proatherogenesis of high FPG.

View Article: PubMed Central - PubMed

Affiliation: Department of Geriatrics, Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, P. R. China. xiangyuzhang2001@yahoo.com.cn.

ABSTRACT

Background: Inflammation plays a critical role in the progression of atherosclerosis, and hyperglycemia is a common feature in patients with ACS. We investigated the relationship between fasting plasma glucose (FPG) levels and the levels of the inflammatory factor, myeloperoxidase (MPO), in patients with acute coronary syndrome (ACS).

Method: A total of 85 patients with no prior history of diabetes mellitus were recruited. The patients were divided into three groups based on their FPG levels as follows: group A, FPG < 5.6 mmol/l; group B, 5.6 mmol/l ≤ FPG < 6.1 mmol/l; and group C, FPG ≥ 6.1 mmol/l. The FPG concentrations and plasma MPO levels were determined, coronary angioplasty was performed, and the Gensini scores were used to evaluate the severity of the coronary lesion. The MPO expression in peripheral blood mononuclear cells (PBMCs) in patients with ACS was determined using western blot analysis.

Result: The results demonstrated that the levels of FPG were significantly and positively correlated with plasma MPO levels, Gensini scores, high sensitive C reaction protein(hs-CRP)levels, leukocyte and neutrophils count. In multivariate regression analyses the FPG levels were positively correlated with plasma MPO levels, Gensini score and hs-CRP. The plasma MPO levels in the group C [68.68(52.62-91.88) U/L] were significantly higher than in the group A [63.04(26.18-97.75) U/L] and group B [58.22(23.95-89.54) U/L]. The plasma hs-CRP concentrations are also higher in group C [42.28 (0.31-169.40) mg/L] than in the group A [12.51(0.28-176.25) mg/L] and group B [14.7 (0.14-89.68) mg/L].

Conclusion: This study demonstrates that FPG values are positively correlated with plasma MPO levels, suggesting MPO may play a role in the proatherogenesis of high FPG.

No MeSH data available.


Related in: MedlinePlus