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Mindfulness is associated with intrinsic functional connectivity between default mode and salience networks.

Doll A, Hölzel BK, Boucard CC, Wohlschläger AM, Sorg C - Front Hum Neurosci (2015)

Bottom Line: Mindfulness practice is associated with brain activity in areas overlapping with the default mode, salience, and central executive networks (DMN, SN, CEN).We hypothesized that intrinsic functional connectivity (iFC; i.e., synchronized ongoing activity) across these networks is associated with mindfulness scores.Results provide evidence that mindfulness is associated with iFC between DMN and SN.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroradiology, Technische Universität München TUM Munich, Germany ; Department of Psychiatry, Technische Universität München TUM Munich, Germany ; TUM-Neuro Imaging Center of Klinikum Rechts der Isar, Technische Universität München TUM Munich, Germany ; Graduate School of Systemic Neurosciences, Ludwig-Maximilians-University Munich, Germany.

ABSTRACT
Mindfulness is attention to present moment experience without judgment. Mindfulness practice is associated with brain activity in areas overlapping with the default mode, salience, and central executive networks (DMN, SN, CEN). We hypothesized that intrinsic functional connectivity (iFC; i.e., synchronized ongoing activity) across these networks is associated with mindfulness scores. After 2 weeks of daily 20 min attention to breath training, healthy participants were assessed by mindfulness questionnaires and resting-state functional MRI. Independent component analysis (ICA) of imaging data revealed networks of interest, whose activity time series defined inter-network intrinsic functional connectivity (inter-iFC) by temporal correlation. Inter-iFC between subnetworks of the DMN and SN-and inter-iFC between subnetworks of the SN and left CEN at trend-was correlated with mindfulness scores. Additional control analyses about visual networks' inter-iFC support the specificity of our findings. Results provide evidence that mindfulness is associated with iFC between DMN and SN. Data suggest that ongoing interactions among central intrinsic brain networks link with the ability to attend to current experience without judgment.

No MeSH data available.


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Association between mindfulness ability and inter-network intrinsic functional connectivity (iFC). Networks are represented by spatial maps of one-sample t-tests (voxel wise family wise error corrected, p < 0.05). Dashed lines indicate negative correlations between mindfulness and connectivity strength. Abbreviations: MAAS, Mindful Attention and Awareness Scale; FMI, Freiburg Mindfulness Inventory; aDMN, anterior default mode network; pvDMN, posterior ventral default mode network; pdDMN, posterior dorsal default mode network; accSN, cingular salience network; insSN, insula salience network; lCEN, left central executive network; rCEN, right central executive network. *significant with Bonferroni correction for multiple comparisons.
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Figure 4: Association between mindfulness ability and inter-network intrinsic functional connectivity (iFC). Networks are represented by spatial maps of one-sample t-tests (voxel wise family wise error corrected, p < 0.05). Dashed lines indicate negative correlations between mindfulness and connectivity strength. Abbreviations: MAAS, Mindful Attention and Awareness Scale; FMI, Freiburg Mindfulness Inventory; aDMN, anterior default mode network; pvDMN, posterior ventral default mode network; pdDMN, posterior dorsal default mode network; accSN, cingular salience network; insSN, insula salience network; lCEN, left central executive network; rCEN, right central executive network. *significant with Bonferroni correction for multiple comparisons.

Mentions: After Fisher r-to-z transformation, we correlated z-scores of inter-iFC with the mindfulness scores of both FMI and MAAS (Pearson correlation, p < 0.05, Bonferroni corrected for 21 comparisons, corrected threshold p < 0.0024; Figures 3, 4; Table 3). We found significant negative correlations between FMI and inter-iFC of insSN and pvDMN (r = −0.60, p < 0.002). In addition, inter-iFC between the aDMN and the pdDMN was significantly negatively correlated with the MAAS scores (r = −0.65, p < 0.001). At border significance (i.e., p < 0.05, but not surviving correction for multiple testing), we found negative associations between MAAS and inter-iFC of aDMN and lCEN (r = −0.40, p < 0.045), FMI and inter-iFC of insSN and aDMN (r = −0.53, significance p < 0.008), as well as FMI and inter-iFC between accSN and lCEN (r = −0.45, p < 0.03).


Mindfulness is associated with intrinsic functional connectivity between default mode and salience networks.

Doll A, Hölzel BK, Boucard CC, Wohlschläger AM, Sorg C - Front Hum Neurosci (2015)

Association between mindfulness ability and inter-network intrinsic functional connectivity (iFC). Networks are represented by spatial maps of one-sample t-tests (voxel wise family wise error corrected, p < 0.05). Dashed lines indicate negative correlations between mindfulness and connectivity strength. Abbreviations: MAAS, Mindful Attention and Awareness Scale; FMI, Freiburg Mindfulness Inventory; aDMN, anterior default mode network; pvDMN, posterior ventral default mode network; pdDMN, posterior dorsal default mode network; accSN, cingular salience network; insSN, insula salience network; lCEN, left central executive network; rCEN, right central executive network. *significant with Bonferroni correction for multiple comparisons.
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Figure 4: Association between mindfulness ability and inter-network intrinsic functional connectivity (iFC). Networks are represented by spatial maps of one-sample t-tests (voxel wise family wise error corrected, p < 0.05). Dashed lines indicate negative correlations between mindfulness and connectivity strength. Abbreviations: MAAS, Mindful Attention and Awareness Scale; FMI, Freiburg Mindfulness Inventory; aDMN, anterior default mode network; pvDMN, posterior ventral default mode network; pdDMN, posterior dorsal default mode network; accSN, cingular salience network; insSN, insula salience network; lCEN, left central executive network; rCEN, right central executive network. *significant with Bonferroni correction for multiple comparisons.
Mentions: After Fisher r-to-z transformation, we correlated z-scores of inter-iFC with the mindfulness scores of both FMI and MAAS (Pearson correlation, p < 0.05, Bonferroni corrected for 21 comparisons, corrected threshold p < 0.0024; Figures 3, 4; Table 3). We found significant negative correlations between FMI and inter-iFC of insSN and pvDMN (r = −0.60, p < 0.002). In addition, inter-iFC between the aDMN and the pdDMN was significantly negatively correlated with the MAAS scores (r = −0.65, p < 0.001). At border significance (i.e., p < 0.05, but not surviving correction for multiple testing), we found negative associations between MAAS and inter-iFC of aDMN and lCEN (r = −0.40, p < 0.045), FMI and inter-iFC of insSN and aDMN (r = −0.53, significance p < 0.008), as well as FMI and inter-iFC between accSN and lCEN (r = −0.45, p < 0.03).

Bottom Line: Mindfulness practice is associated with brain activity in areas overlapping with the default mode, salience, and central executive networks (DMN, SN, CEN).We hypothesized that intrinsic functional connectivity (iFC; i.e., synchronized ongoing activity) across these networks is associated with mindfulness scores.Results provide evidence that mindfulness is associated with iFC between DMN and SN.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroradiology, Technische Universität München TUM Munich, Germany ; Department of Psychiatry, Technische Universität München TUM Munich, Germany ; TUM-Neuro Imaging Center of Klinikum Rechts der Isar, Technische Universität München TUM Munich, Germany ; Graduate School of Systemic Neurosciences, Ludwig-Maximilians-University Munich, Germany.

ABSTRACT
Mindfulness is attention to present moment experience without judgment. Mindfulness practice is associated with brain activity in areas overlapping with the default mode, salience, and central executive networks (DMN, SN, CEN). We hypothesized that intrinsic functional connectivity (iFC; i.e., synchronized ongoing activity) across these networks is associated with mindfulness scores. After 2 weeks of daily 20 min attention to breath training, healthy participants were assessed by mindfulness questionnaires and resting-state functional MRI. Independent component analysis (ICA) of imaging data revealed networks of interest, whose activity time series defined inter-network intrinsic functional connectivity (inter-iFC) by temporal correlation. Inter-iFC between subnetworks of the DMN and SN-and inter-iFC between subnetworks of the SN and left CEN at trend-was correlated with mindfulness scores. Additional control analyses about visual networks' inter-iFC support the specificity of our findings. Results provide evidence that mindfulness is associated with iFC between DMN and SN. Data suggest that ongoing interactions among central intrinsic brain networks link with the ability to attend to current experience without judgment.

No MeSH data available.


Related in: MedlinePlus