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Alteration of Basal Ganglia and Right Frontoparietal Network in Early Drug-Naïve Parkinson's Disease during Heat Pain Stimuli and Resting State.

Tan Y, Tan J, Deng J, Cui W, He H, Yang F, Deng H, Xiao R, Huang Z, Zhang X, Tan R, Shen X, Liu T, Wang X, Yao D, Luo C - Front Hum Neurosci (2015)

Bottom Line: We focused on abnormalities in FC and in functional network connectivity (FNC) in PD compared with HC during the task (51°C heat pain stimuli) and at rest.FNC between the BGN and the SN are reduced during both states in PD compared with HC.In addition, right frontoparietal network (RFPN), which is considered as a bridge between the SN and default-mode network, was significantly disturbed during the task.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, University of Electronic Science and Technology of China , Chengdu , China ; School of Computer Science and Technology, Southwest University for Nationalities , Chengdu , China.

ABSTRACT

Background: The symptoms and pathogenesis of Parkinson's disease (PD) are complicated and an accurate diagnosis of PD is difficult, particularly in early-stage. Because functional magnetic resonance imaging (fMRI) is non-invasive and is characterized by the integration of different brain areas in terms of functional connectivity (FC), fMRI has been widely used in PD research. Non-motor symptom (NMS) features are also frequently present in PD before the onset of classical motor symptoms with pain as the primary NMS. Considering that PD could affect the pain process at multiple levels, we hypothesized that pain is one of the earliest symptoms in PD and investigated whether FC of the pain network was disrupted in PD without pain. To better understand the pathogenesis of pain in PD, we combined resting state and pain-stimuli-induced task state fMRI to identify alterations in FC related to pain in PD.

Methods: Fourteen early drug-naïve PD without pain and 17 age- and sex-matched healthy controls (HC) participated in our testing task. We used independent component analysis to select seven functional networks related to PD and pain. We focused on abnormalities in FC and in functional network connectivity (FNC) in PD compared with HC during the task (51°C heat pain stimuli) and at rest.

Results: Compared with HC, PD showed decreased FC in putamen within basal ganglia network (BGN) in task state and decreased FC in putamen of salience network (SN) and mid-cingulate cortex of sensorimotor network in rest state. FNC between the BGN and the SN are reduced during both states in PD compared with HC. In addition, right frontoparietal network (RFPN), which is considered as a bridge between the SN and default-mode network, was significantly disturbed during the task.

Conclusion: These findings suggest that BGN plays a role in the pathological mechanisms of pain underlying PD, and RFPN likely contributes greatly to harmonization between intrinsic brain activity and external stimuli.

No MeSH data available.


Related in: MedlinePlus

Spatial maps of the seven selected independent components. Column bar shows t contrast threshold. L, left; R, right.
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Figure 1: Spatial maps of the seven selected independent components. Column bar shows t contrast threshold. L, left; R, right.

Mentions: Based on the experience of pain-related and PD-related ICNs (Wu et al., 2009; Otti et al., 2013; Szewczyk-Krolikowski et al., 2014; Baggio et al., 2015), 7 of the 47 ICA components were inspected visually for confirmation of non-artifact changes. These components included the basal ganglia network (BGN, IC #19), the right frontoparietal network (RFPN, IC #31), the salience network (SN, IC #10), the DMN (IC #30), the sensorimotor network (SMN, IC #15), the cerebellum network (CN, IC #3), and the left frontoparietal network (LFPN, IC #39) (Figure 1).


Alteration of Basal Ganglia and Right Frontoparietal Network in Early Drug-Naïve Parkinson's Disease during Heat Pain Stimuli and Resting State.

Tan Y, Tan J, Deng J, Cui W, He H, Yang F, Deng H, Xiao R, Huang Z, Zhang X, Tan R, Shen X, Liu T, Wang X, Yao D, Luo C - Front Hum Neurosci (2015)

Spatial maps of the seven selected independent components. Column bar shows t contrast threshold. L, left; R, right.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4547030&req=5

Figure 1: Spatial maps of the seven selected independent components. Column bar shows t contrast threshold. L, left; R, right.
Mentions: Based on the experience of pain-related and PD-related ICNs (Wu et al., 2009; Otti et al., 2013; Szewczyk-Krolikowski et al., 2014; Baggio et al., 2015), 7 of the 47 ICA components were inspected visually for confirmation of non-artifact changes. These components included the basal ganglia network (BGN, IC #19), the right frontoparietal network (RFPN, IC #31), the salience network (SN, IC #10), the DMN (IC #30), the sensorimotor network (SMN, IC #15), the cerebellum network (CN, IC #3), and the left frontoparietal network (LFPN, IC #39) (Figure 1).

Bottom Line: We focused on abnormalities in FC and in functional network connectivity (FNC) in PD compared with HC during the task (51°C heat pain stimuli) and at rest.FNC between the BGN and the SN are reduced during both states in PD compared with HC.In addition, right frontoparietal network (RFPN), which is considered as a bridge between the SN and default-mode network, was significantly disturbed during the task.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, University of Electronic Science and Technology of China , Chengdu , China ; School of Computer Science and Technology, Southwest University for Nationalities , Chengdu , China.

ABSTRACT

Background: The symptoms and pathogenesis of Parkinson's disease (PD) are complicated and an accurate diagnosis of PD is difficult, particularly in early-stage. Because functional magnetic resonance imaging (fMRI) is non-invasive and is characterized by the integration of different brain areas in terms of functional connectivity (FC), fMRI has been widely used in PD research. Non-motor symptom (NMS) features are also frequently present in PD before the onset of classical motor symptoms with pain as the primary NMS. Considering that PD could affect the pain process at multiple levels, we hypothesized that pain is one of the earliest symptoms in PD and investigated whether FC of the pain network was disrupted in PD without pain. To better understand the pathogenesis of pain in PD, we combined resting state and pain-stimuli-induced task state fMRI to identify alterations in FC related to pain in PD.

Methods: Fourteen early drug-naïve PD without pain and 17 age- and sex-matched healthy controls (HC) participated in our testing task. We used independent component analysis to select seven functional networks related to PD and pain. We focused on abnormalities in FC and in functional network connectivity (FNC) in PD compared with HC during the task (51°C heat pain stimuli) and at rest.

Results: Compared with HC, PD showed decreased FC in putamen within basal ganglia network (BGN) in task state and decreased FC in putamen of salience network (SN) and mid-cingulate cortex of sensorimotor network in rest state. FNC between the BGN and the SN are reduced during both states in PD compared with HC. In addition, right frontoparietal network (RFPN), which is considered as a bridge between the SN and default-mode network, was significantly disturbed during the task.

Conclusion: These findings suggest that BGN plays a role in the pathological mechanisms of pain underlying PD, and RFPN likely contributes greatly to harmonization between intrinsic brain activity and external stimuli.

No MeSH data available.


Related in: MedlinePlus