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Lecithin-based wet chemical precipitation of hydroxyapatite nanoparticles.

Michał W, Ewa D, Tomasz C - Colloid Polym Sci (2015)

Bottom Line: Size distribution for nanoparticles was measured by nanoparticle tracking analysis in NanoSight system.We discuss in details influence of lecithin concentration in reaction system on nHAp-PC morphology, as well as on size distributions and suspendability of nanoparticles.Difference in surfactant amounts results in changes in particles morphology and their average size.

View Article: PubMed Central - PubMed

Affiliation: BioMedical Engineering Laboratory, Faculty of Chemical and Process Engineering, Warsaw University of Technology, Waryńskiego 1, 00-645 Warszawa, Poland.

ABSTRACT

Hydroxyapatite Ca10(PO4)6(OH)2 nanoparticles have been successfully synthesized by the wet chemical precipitation method at 60 °C in the presence of biocompatible natural surfactant-lecithin. The composition and morphology of nanoparticles of hydroxyapatite synthesized with lecithin (nHAp-PC) was studied by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Size distribution for nanoparticles was measured by nanoparticle tracking analysis in NanoSight system. We discuss in details influence of lecithin concentration in reaction system on nHAp-PC morphology, as well as on size distributions and suspendability of nanoparticles. Product exhibits crystalline structure and chemical composition of hydroxyapatite, with visible traces of lecithin. Difference in surfactant amounts results in changes in particles morphology and their average size.

No MeSH data available.


Related in: MedlinePlus

SEM images of lecithin-based wet chemical precipitation synthesized hydroxyapatite nanoparticles: a 0.30 % w/w lecithin, b 0.75 % w/w lecithin, c 1.50 % w/w lecithin, d 3.00 % w/w lecithin, e 9.00 % w/w lecithin, and f enlargement of 9.00 % w/w lecithin; note the difference in scale
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Fig3: SEM images of lecithin-based wet chemical precipitation synthesized hydroxyapatite nanoparticles: a 0.30 % w/w lecithin, b 0.75 % w/w lecithin, c 1.50 % w/w lecithin, d 3.00 % w/w lecithin, e 9.00 % w/w lecithin, and f enlargement of 9.00 % w/w lecithin; note the difference in scale

Mentions: Scanning electron microscope images in Fig. 3 present the morphology of nHAp-PC particles synthesized in the system with amount of lecithin in the range from 0.30 to 9.00 % w/w. We observed dependence of nHAp-PC particles morphology as a function of amount of lecithin added to synthesis system in proposed process. Part (a) in Fig. 3 shows the plate-like morphology, mostly nanoplates with thickness up to hundreds of nanometers, as a dominant form. But, we noticed some accompanying particles without specific geometrical form. The nanoplate morphology of the nHAp-PC corresponds with the lowest, in investigated range, amount of added lecithin—0.30 % w/w. With increasing the lecithin concentration through 0.75 to 1.50 % w/w, we obtained nanoparticles in form of nanorods. In part (b) of Fig. 3, we present how for increasing amount of lecithin, nanoparticles, become thinner in diameter and longer. Further increase of lecithin amount in the synthesis system, to 3.00 and 9.00 % w/w, resulted with particles in form of nanospheres. Based on SEM images (Fig. 3d–f), we noticed two effects for these powders: (1) increased lecithin concentration to 9.00 % w/w caused formation of bigger nanoparticles than for 3.00 % w/w; (2) the adhesion-like effect appears between the nHAp-PC, particles form cauliflower-like structure. The second observation inspired us to investigate the nanoparticles suspendability in aqueous suspensions.Fig. 3


Lecithin-based wet chemical precipitation of hydroxyapatite nanoparticles.

Michał W, Ewa D, Tomasz C - Colloid Polym Sci (2015)

SEM images of lecithin-based wet chemical precipitation synthesized hydroxyapatite nanoparticles: a 0.30 % w/w lecithin, b 0.75 % w/w lecithin, c 1.50 % w/w lecithin, d 3.00 % w/w lecithin, e 9.00 % w/w lecithin, and f enlargement of 9.00 % w/w lecithin; note the difference in scale
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Related In: Results  -  Collection

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Fig3: SEM images of lecithin-based wet chemical precipitation synthesized hydroxyapatite nanoparticles: a 0.30 % w/w lecithin, b 0.75 % w/w lecithin, c 1.50 % w/w lecithin, d 3.00 % w/w lecithin, e 9.00 % w/w lecithin, and f enlargement of 9.00 % w/w lecithin; note the difference in scale
Mentions: Scanning electron microscope images in Fig. 3 present the morphology of nHAp-PC particles synthesized in the system with amount of lecithin in the range from 0.30 to 9.00 % w/w. We observed dependence of nHAp-PC particles morphology as a function of amount of lecithin added to synthesis system in proposed process. Part (a) in Fig. 3 shows the plate-like morphology, mostly nanoplates with thickness up to hundreds of nanometers, as a dominant form. But, we noticed some accompanying particles without specific geometrical form. The nanoplate morphology of the nHAp-PC corresponds with the lowest, in investigated range, amount of added lecithin—0.30 % w/w. With increasing the lecithin concentration through 0.75 to 1.50 % w/w, we obtained nanoparticles in form of nanorods. In part (b) of Fig. 3, we present how for increasing amount of lecithin, nanoparticles, become thinner in diameter and longer. Further increase of lecithin amount in the synthesis system, to 3.00 and 9.00 % w/w, resulted with particles in form of nanospheres. Based on SEM images (Fig. 3d–f), we noticed two effects for these powders: (1) increased lecithin concentration to 9.00 % w/w caused formation of bigger nanoparticles than for 3.00 % w/w; (2) the adhesion-like effect appears between the nHAp-PC, particles form cauliflower-like structure. The second observation inspired us to investigate the nanoparticles suspendability in aqueous suspensions.Fig. 3

Bottom Line: Size distribution for nanoparticles was measured by nanoparticle tracking analysis in NanoSight system.We discuss in details influence of lecithin concentration in reaction system on nHAp-PC morphology, as well as on size distributions and suspendability of nanoparticles.Difference in surfactant amounts results in changes in particles morphology and their average size.

View Article: PubMed Central - PubMed

Affiliation: BioMedical Engineering Laboratory, Faculty of Chemical and Process Engineering, Warsaw University of Technology, Waryńskiego 1, 00-645 Warszawa, Poland.

ABSTRACT

Hydroxyapatite Ca10(PO4)6(OH)2 nanoparticles have been successfully synthesized by the wet chemical precipitation method at 60 °C in the presence of biocompatible natural surfactant-lecithin. The composition and morphology of nanoparticles of hydroxyapatite synthesized with lecithin (nHAp-PC) was studied by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Size distribution for nanoparticles was measured by nanoparticle tracking analysis in NanoSight system. We discuss in details influence of lecithin concentration in reaction system on nHAp-PC morphology, as well as on size distributions and suspendability of nanoparticles. Product exhibits crystalline structure and chemical composition of hydroxyapatite, with visible traces of lecithin. Difference in surfactant amounts results in changes in particles morphology and their average size.

No MeSH data available.


Related in: MedlinePlus