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Androgenetic alopecia: new insights into the pathogenesis and mechanism of hair loss.

Sinclair R, Torkamani N, Jones L - F1000Res (2015)

Bottom Line: The hair follicle is a complete mini-organ that lends itself as a model for investigation of a variety of complex biological phenomena, including stem cell biology, organ regeneration and cloning.  The arrector pili muscle inserts into the hair follicle at the level of the bulge- the epithelial stem cell niche.  The arrector pili muscle has been previously thought to be merely a bystander and not to have an active role in hair disease.Computer generated 3D reconstructions of the arrector pili muscle have helped explain why women with androgenetic alopecia (AGA) experience diffuse hair loss rather than the patterned baldness seen in men.  Loss of attachment between the bulge stem cell population and the arrector pili muscle also explains why miniaturization is irreversible in AGA but not alopecia areata.A new model for the progression of AGA is presented.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, University of Melbourne, Victoria, Australia ; Epworth Dermatology, Victoria, Australia ; Sinclair Dermatology, Victoria, Australia.

ABSTRACT
The hair follicle is a complete mini-organ that lends itself as a model for investigation of a variety of complex biological phenomena, including stem cell biology, organ regeneration and cloning.  The arrector pili muscle inserts into the hair follicle at the level of the bulge- the epithelial stem cell niche.  The arrector pili muscle has been previously thought to be merely a bystander and not to have an active role in hair disease. Computer generated 3D reconstructions of the arrector pili muscle have helped explain why women with androgenetic alopecia (AGA) experience diffuse hair loss rather than the patterned baldness seen in men.  Loss of attachment between the bulge stem cell population and the arrector pili muscle also explains why miniaturization is irreversible in AGA but not alopecia areata. A new model for the progression of AGA is presented.

No MeSH data available.


Related in: MedlinePlus

Hair shedding scale.Women are asked which image best corresponds to the amount of hair shed on an average day. Grades 1 to 4 are considered normal for women with long hair. Grades 5 and 6 indicate excessive shedding. Seventy percent of women with female pattern hair loss have excessive shedding.
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f2: Hair shedding scale.Women are asked which image best corresponds to the amount of hair shed on an average day. Grades 1 to 4 are considered normal for women with long hair. Grades 5 and 6 indicate excessive shedding. Seventy percent of women with female pattern hair loss have excessive shedding.

Mentions: Diffuse hair thinning and sometimes increased hair shedding (Figure 2) precede the clinical appearance of baldness by a number of years6. This is because the process of follicular miniaturization which occurs in AGA does not simultaneously affect all follicles within a follicular unit (FU). Instead, there is a hierarchy of follicular miniaturization within FUs, and secondary follicles are affected initially and primary follicles are miniaturized last7.


Androgenetic alopecia: new insights into the pathogenesis and mechanism of hair loss.

Sinclair R, Torkamani N, Jones L - F1000Res (2015)

Hair shedding scale.Women are asked which image best corresponds to the amount of hair shed on an average day. Grades 1 to 4 are considered normal for women with long hair. Grades 5 and 6 indicate excessive shedding. Seventy percent of women with female pattern hair loss have excessive shedding.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4544386&req=5

f2: Hair shedding scale.Women are asked which image best corresponds to the amount of hair shed on an average day. Grades 1 to 4 are considered normal for women with long hair. Grades 5 and 6 indicate excessive shedding. Seventy percent of women with female pattern hair loss have excessive shedding.
Mentions: Diffuse hair thinning and sometimes increased hair shedding (Figure 2) precede the clinical appearance of baldness by a number of years6. This is because the process of follicular miniaturization which occurs in AGA does not simultaneously affect all follicles within a follicular unit (FU). Instead, there is a hierarchy of follicular miniaturization within FUs, and secondary follicles are affected initially and primary follicles are miniaturized last7.

Bottom Line: The hair follicle is a complete mini-organ that lends itself as a model for investigation of a variety of complex biological phenomena, including stem cell biology, organ regeneration and cloning.  The arrector pili muscle inserts into the hair follicle at the level of the bulge- the epithelial stem cell niche.  The arrector pili muscle has been previously thought to be merely a bystander and not to have an active role in hair disease.Computer generated 3D reconstructions of the arrector pili muscle have helped explain why women with androgenetic alopecia (AGA) experience diffuse hair loss rather than the patterned baldness seen in men.  Loss of attachment between the bulge stem cell population and the arrector pili muscle also explains why miniaturization is irreversible in AGA but not alopecia areata.A new model for the progression of AGA is presented.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, University of Melbourne, Victoria, Australia ; Epworth Dermatology, Victoria, Australia ; Sinclair Dermatology, Victoria, Australia.

ABSTRACT
The hair follicle is a complete mini-organ that lends itself as a model for investigation of a variety of complex biological phenomena, including stem cell biology, organ regeneration and cloning.  The arrector pili muscle inserts into the hair follicle at the level of the bulge- the epithelial stem cell niche.  The arrector pili muscle has been previously thought to be merely a bystander and not to have an active role in hair disease. Computer generated 3D reconstructions of the arrector pili muscle have helped explain why women with androgenetic alopecia (AGA) experience diffuse hair loss rather than the patterned baldness seen in men.  Loss of attachment between the bulge stem cell population and the arrector pili muscle also explains why miniaturization is irreversible in AGA but not alopecia areata. A new model for the progression of AGA is presented.

No MeSH data available.


Related in: MedlinePlus