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Effect of Extra Virgin Olive Oil on Biomarkers of Inflammation in HIV-Infected Patients: A Randomized, Crossover, Controlled Clinical Trial.

Kozić Dokmanović S, Kolovrat K, Laškaj R, Jukić V, Vrkić N, Begovac J - Med. Sci. Monit. (2015)

Bottom Line: Extra virgin olive oil (EVOO) has a beneficial effect on the cardiovascular system because of its anti-inflammatory properties.In participants using lopinavir/ritonavir, ESR and hsCRP concentrations decreased 62% and 151%, respectively, after EVOO administration.In the whole study population (N=35) we found no difference in analyzed biomarkers after EVOO administration.

View Article: PubMed Central - PubMed

Affiliation: Department for Biochemistry and Hematology, University Hospital for Infectious Diseases "Dr Fran Mihaljević", Zagreb, Croatia.

ABSTRACT

Background: Premature atherosclerosis in HIV-infected patients is associated with chronic infection by itself and adverse effects of antiretroviral treatment (ART). Extra virgin olive oil (EVOO) has a beneficial effect on the cardiovascular system because of its anti-inflammatory properties. The objective of this study was to determine whether the consumption of EVOO improves inflammation and atherosclerosis biomarkers in HIV-infected patients receiving ART.

Material and methods: This randomized, crossover, controlled trial included 39 HIV-positive male participants who consumed 50 mL of EVOO or refined olive oil (ROO) daily. Four participants dropped out of the study. Leukocyte count, erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hsCRP), interleukin-6, fibrinogen, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, malondialdehyde, glutathione-peroxidase, superoxide dismutase, oxidized LDL and von Willebrand factor were determined before the first and after each of the 2 intervention periods. Intervention and washout periods lasted for 20 and 14 days, respectively.

Results: In participants with >90% compliance (N=30), hsCRP concentrations were lower after EVOO intervention (geometric mean [GM], 1.70 mg/L; 95% confidence interval [CI], 1.15-2.52) compared to ROO administration (GM, 2.92 mg/L; 95% CI, 1.95-4.37) (p=0.035). In participants using lopinavir/ritonavir, ESR and hsCRP concentrations decreased 62% and 151%, respectively, after EVOO administration. In the whole study population (N=35) we found no difference in analyzed biomarkers after EVOO administration.

Conclusions: Our exploratory study suggests that EVOO consumption could lower hsCRP in patients on ART.

No MeSH data available.


Related in: MedlinePlus

High-sensitivity C-reactive protein (hsCRP) values at baseline and after extra virgin olive oil (EVOO) and refined olive oil (ROO) administration in a crossover study with a subanalysis of 10 patients receiving the protease inhibitor lopinavir/ritonavir. Data are plotted on a logarithmic scale to reduce positive skewness in the distributions. The horizontal line is the geometric mean with 95% confidence interval (P<0.05 for the differences in groups).
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f3-medscimonit-21-2406: High-sensitivity C-reactive protein (hsCRP) values at baseline and after extra virgin olive oil (EVOO) and refined olive oil (ROO) administration in a crossover study with a subanalysis of 10 patients receiving the protease inhibitor lopinavir/ritonavir. Data are plotted on a logarithmic scale to reduce positive skewness in the distributions. The horizontal line is the geometric mean with 95% confidence interval (P<0.05 for the differences in groups).

Mentions: When the effect of olive oil administration was analyzed in 10 participants who received PI lopinavir/ritonavir, EVOO intervention resulted in a 62% lower ESR compared to baseline values (median, 13; IQR, 6–19 vs. median, 21; IQR, 10–36; p=0.040). In the same group of participants, we observed 151% lower hsCRP concentrations after EVOO administration, compared to baseline values (median, 0.88 mg/L; IQR, 0.49–1.66 vs. median, 2.21 mg/L; IQR, 1.82–5.47; p=0.035) (Figure 3). Participants receiving lopinavir/ritonavir had a higher baseline fibrinogen concentration (median, 3.9 g/L; IQR, 3.3–4.4) than participants treated with a NNRTI-based ART (median, 3.0 g/L; IQR, 3.7–3.4) (p=0.004).


Effect of Extra Virgin Olive Oil on Biomarkers of Inflammation in HIV-Infected Patients: A Randomized, Crossover, Controlled Clinical Trial.

Kozić Dokmanović S, Kolovrat K, Laškaj R, Jukić V, Vrkić N, Begovac J - Med. Sci. Monit. (2015)

High-sensitivity C-reactive protein (hsCRP) values at baseline and after extra virgin olive oil (EVOO) and refined olive oil (ROO) administration in a crossover study with a subanalysis of 10 patients receiving the protease inhibitor lopinavir/ritonavir. Data are plotted on a logarithmic scale to reduce positive skewness in the distributions. The horizontal line is the geometric mean with 95% confidence interval (P<0.05 for the differences in groups).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4544351&req=5

f3-medscimonit-21-2406: High-sensitivity C-reactive protein (hsCRP) values at baseline and after extra virgin olive oil (EVOO) and refined olive oil (ROO) administration in a crossover study with a subanalysis of 10 patients receiving the protease inhibitor lopinavir/ritonavir. Data are plotted on a logarithmic scale to reduce positive skewness in the distributions. The horizontal line is the geometric mean with 95% confidence interval (P<0.05 for the differences in groups).
Mentions: When the effect of olive oil administration was analyzed in 10 participants who received PI lopinavir/ritonavir, EVOO intervention resulted in a 62% lower ESR compared to baseline values (median, 13; IQR, 6–19 vs. median, 21; IQR, 10–36; p=0.040). In the same group of participants, we observed 151% lower hsCRP concentrations after EVOO administration, compared to baseline values (median, 0.88 mg/L; IQR, 0.49–1.66 vs. median, 2.21 mg/L; IQR, 1.82–5.47; p=0.035) (Figure 3). Participants receiving lopinavir/ritonavir had a higher baseline fibrinogen concentration (median, 3.9 g/L; IQR, 3.3–4.4) than participants treated with a NNRTI-based ART (median, 3.0 g/L; IQR, 3.7–3.4) (p=0.004).

Bottom Line: Extra virgin olive oil (EVOO) has a beneficial effect on the cardiovascular system because of its anti-inflammatory properties.In participants using lopinavir/ritonavir, ESR and hsCRP concentrations decreased 62% and 151%, respectively, after EVOO administration.In the whole study population (N=35) we found no difference in analyzed biomarkers after EVOO administration.

View Article: PubMed Central - PubMed

Affiliation: Department for Biochemistry and Hematology, University Hospital for Infectious Diseases "Dr Fran Mihaljević", Zagreb, Croatia.

ABSTRACT

Background: Premature atherosclerosis in HIV-infected patients is associated with chronic infection by itself and adverse effects of antiretroviral treatment (ART). Extra virgin olive oil (EVOO) has a beneficial effect on the cardiovascular system because of its anti-inflammatory properties. The objective of this study was to determine whether the consumption of EVOO improves inflammation and atherosclerosis biomarkers in HIV-infected patients receiving ART.

Material and methods: This randomized, crossover, controlled trial included 39 HIV-positive male participants who consumed 50 mL of EVOO or refined olive oil (ROO) daily. Four participants dropped out of the study. Leukocyte count, erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hsCRP), interleukin-6, fibrinogen, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, malondialdehyde, glutathione-peroxidase, superoxide dismutase, oxidized LDL and von Willebrand factor were determined before the first and after each of the 2 intervention periods. Intervention and washout periods lasted for 20 and 14 days, respectively.

Results: In participants with >90% compliance (N=30), hsCRP concentrations were lower after EVOO intervention (geometric mean [GM], 1.70 mg/L; 95% confidence interval [CI], 1.15-2.52) compared to ROO administration (GM, 2.92 mg/L; 95% CI, 1.95-4.37) (p=0.035). In participants using lopinavir/ritonavir, ESR and hsCRP concentrations decreased 62% and 151%, respectively, after EVOO administration. In the whole study population (N=35) we found no difference in analyzed biomarkers after EVOO administration.

Conclusions: Our exploratory study suggests that EVOO consumption could lower hsCRP in patients on ART.

No MeSH data available.


Related in: MedlinePlus