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Effect of Extra Virgin Olive Oil on Biomarkers of Inflammation in HIV-Infected Patients: A Randomized, Crossover, Controlled Clinical Trial.

Kozić Dokmanović S, Kolovrat K, Laškaj R, Jukić V, Vrkić N, Begovac J - Med. Sci. Monit. (2015)

Bottom Line: Extra virgin olive oil (EVOO) has a beneficial effect on the cardiovascular system because of its anti-inflammatory properties.In participants using lopinavir/ritonavir, ESR and hsCRP concentrations decreased 62% and 151%, respectively, after EVOO administration.In the whole study population (N=35) we found no difference in analyzed biomarkers after EVOO administration.

View Article: PubMed Central - PubMed

Affiliation: Department for Biochemistry and Hematology, University Hospital for Infectious Diseases "Dr Fran Mihaljević", Zagreb, Croatia.

ABSTRACT

Background: Premature atherosclerosis in HIV-infected patients is associated with chronic infection by itself and adverse effects of antiretroviral treatment (ART). Extra virgin olive oil (EVOO) has a beneficial effect on the cardiovascular system because of its anti-inflammatory properties. The objective of this study was to determine whether the consumption of EVOO improves inflammation and atherosclerosis biomarkers in HIV-infected patients receiving ART.

Material and methods: This randomized, crossover, controlled trial included 39 HIV-positive male participants who consumed 50 mL of EVOO or refined olive oil (ROO) daily. Four participants dropped out of the study. Leukocyte count, erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hsCRP), interleukin-6, fibrinogen, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, malondialdehyde, glutathione-peroxidase, superoxide dismutase, oxidized LDL and von Willebrand factor were determined before the first and after each of the 2 intervention periods. Intervention and washout periods lasted for 20 and 14 days, respectively.

Results: In participants with >90% compliance (N=30), hsCRP concentrations were lower after EVOO intervention (geometric mean [GM], 1.70 mg/L; 95% confidence interval [CI], 1.15-2.52) compared to ROO administration (GM, 2.92 mg/L; 95% CI, 1.95-4.37) (p=0.035). In participants using lopinavir/ritonavir, ESR and hsCRP concentrations decreased 62% and 151%, respectively, after EVOO administration. In the whole study population (N=35) we found no difference in analyzed biomarkers after EVOO administration.

Conclusions: Our exploratory study suggests that EVOO consumption could lower hsCRP in patients on ART.

No MeSH data available.


Related in: MedlinePlus

High-sensitivity C-reactive protein (hsCRP) values after extra virgin olive oil (EVOO) and refined olive oil (ROO) administration in a crossover study of 30 HIV-infected patients who completed at least 1 intervention period and had > 90% adherence. Data are plotted on a logarithmic scale to reduce positive skewness in the distributions. The geometric mean with 95% confidence intervals is presented (P=0.035 for comparison of EVOO and ROO consumption).
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f2-medscimonit-21-2406: High-sensitivity C-reactive protein (hsCRP) values after extra virgin olive oil (EVOO) and refined olive oil (ROO) administration in a crossover study of 30 HIV-infected patients who completed at least 1 intervention period and had > 90% adherence. Data are plotted on a logarithmic scale to reduce positive skewness in the distributions. The geometric mean with 95% confidence intervals is presented (P=0.035 for comparison of EVOO and ROO consumption).

Mentions: Thirty participants reported consuming olive oils >90% of the time; 27 participants were compliant to EVOO and 26 participants were compliant to ROO administration. Of those 30 individuals, 23 were compliant to both olive oils, 4 were compliant only to EVOO, and 3 were compliant only to ROO. In adherent participants (>90%), we found significantly lower hsCRP concentration after EVOO administration compared to hsCRP concentration after ROO administration (geometric mean [GM], 1.70 mg/L; 95% confidence interval [CI], 1.15–2.52 vs. 2.92 mg/L; 95% CI, 1.95–4.37; p=0.035) (Figure 2).


Effect of Extra Virgin Olive Oil on Biomarkers of Inflammation in HIV-Infected Patients: A Randomized, Crossover, Controlled Clinical Trial.

Kozić Dokmanović S, Kolovrat K, Laškaj R, Jukić V, Vrkić N, Begovac J - Med. Sci. Monit. (2015)

High-sensitivity C-reactive protein (hsCRP) values after extra virgin olive oil (EVOO) and refined olive oil (ROO) administration in a crossover study of 30 HIV-infected patients who completed at least 1 intervention period and had > 90% adherence. Data are plotted on a logarithmic scale to reduce positive skewness in the distributions. The geometric mean with 95% confidence intervals is presented (P=0.035 for comparison of EVOO and ROO consumption).
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4544351&req=5

f2-medscimonit-21-2406: High-sensitivity C-reactive protein (hsCRP) values after extra virgin olive oil (EVOO) and refined olive oil (ROO) administration in a crossover study of 30 HIV-infected patients who completed at least 1 intervention period and had > 90% adherence. Data are plotted on a logarithmic scale to reduce positive skewness in the distributions. The geometric mean with 95% confidence intervals is presented (P=0.035 for comparison of EVOO and ROO consumption).
Mentions: Thirty participants reported consuming olive oils >90% of the time; 27 participants were compliant to EVOO and 26 participants were compliant to ROO administration. Of those 30 individuals, 23 were compliant to both olive oils, 4 were compliant only to EVOO, and 3 were compliant only to ROO. In adherent participants (>90%), we found significantly lower hsCRP concentration after EVOO administration compared to hsCRP concentration after ROO administration (geometric mean [GM], 1.70 mg/L; 95% confidence interval [CI], 1.15–2.52 vs. 2.92 mg/L; 95% CI, 1.95–4.37; p=0.035) (Figure 2).

Bottom Line: Extra virgin olive oil (EVOO) has a beneficial effect on the cardiovascular system because of its anti-inflammatory properties.In participants using lopinavir/ritonavir, ESR and hsCRP concentrations decreased 62% and 151%, respectively, after EVOO administration.In the whole study population (N=35) we found no difference in analyzed biomarkers after EVOO administration.

View Article: PubMed Central - PubMed

Affiliation: Department for Biochemistry and Hematology, University Hospital for Infectious Diseases "Dr Fran Mihaljević", Zagreb, Croatia.

ABSTRACT

Background: Premature atherosclerosis in HIV-infected patients is associated with chronic infection by itself and adverse effects of antiretroviral treatment (ART). Extra virgin olive oil (EVOO) has a beneficial effect on the cardiovascular system because of its anti-inflammatory properties. The objective of this study was to determine whether the consumption of EVOO improves inflammation and atherosclerosis biomarkers in HIV-infected patients receiving ART.

Material and methods: This randomized, crossover, controlled trial included 39 HIV-positive male participants who consumed 50 mL of EVOO or refined olive oil (ROO) daily. Four participants dropped out of the study. Leukocyte count, erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hsCRP), interleukin-6, fibrinogen, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, malondialdehyde, glutathione-peroxidase, superoxide dismutase, oxidized LDL and von Willebrand factor were determined before the first and after each of the 2 intervention periods. Intervention and washout periods lasted for 20 and 14 days, respectively.

Results: In participants with >90% compliance (N=30), hsCRP concentrations were lower after EVOO intervention (geometric mean [GM], 1.70 mg/L; 95% confidence interval [CI], 1.15-2.52) compared to ROO administration (GM, 2.92 mg/L; 95% CI, 1.95-4.37) (p=0.035). In participants using lopinavir/ritonavir, ESR and hsCRP concentrations decreased 62% and 151%, respectively, after EVOO administration. In the whole study population (N=35) we found no difference in analyzed biomarkers after EVOO administration.

Conclusions: Our exploratory study suggests that EVOO consumption could lower hsCRP in patients on ART.

No MeSH data available.


Related in: MedlinePlus